Bimakalim
Basic information
- CAS
117545-11-6- Standard SMILES
CC1(C)C=C(n2ccccc2=O)c2cc(C#N)ccc2O1- InChIKey
JTVSKASWNROQQF-UHFFFAOYSA-N- Molecular formula
- C17H14N2O2
- Average molar mass
- 278.3 g/mol
- Monoisotopic mass
- 278.10552769
Overview
Bimakalim is a small molecule drug. The usage of the INN stem '-kalim' in the name indicates that Bimakalim is a potassium channel activator, antihypertensive. Bimakalim has a monoisotopic molecular weight of 278.11 Da.
Names & identifiers
- Preferred name
- Bimakalim
- IUPAC
- 2,2-dimethyl-4-(2-oxo-1-pyridinyl)chromene-6-carbonitrile
- English name
- Bimakalim
- Molecular formula
- C17H14N2O2
- Molecular weight
- 278.31
Names & synonyms
BIMAKALIM117545-11-6BimakalimumEMD-52692SR-448664MP5GR4H9LDTXSID401518034-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-2H-1-benzopyran-6-carbonitrileRefChem:917196DTXCID7074294Bimakalim [INN]2,2-dimethyl-4-(2-oxopyridin-1-yl)chromene-6-carbonitrile
Show more names
6-Cyano-4-(2-oxo-1,2-dihydropyridine-1-yl)-2,2-dimethyl-2H-1-benzopyran2,2-Dimethyl-6-cyano-4-[(1,2-dihydro-2-oxopyridin)-1-yl]-2H-1-benzopyran2,2-Dimethyl-4-(1,2-dihydro-2-oxopyridine-1-yl)-2H-1-benzopyran-6-carbonitrile
2H-1-Benzopyran-6-carbonitrile, 2,2-dimethyl-4-(2-oxo-1(2H)-pyridinyl)-2,2-Dimethyl-4-(2-oxo-1(2H)-pyridyl)-2H-1-benzopyran-6-carbonitrileBimakalimum [INN-Latin]UNII-4MP5GR4H9L2,2-dimethyl-4-(2-oxopyridin-1(2H)-yl)-2H-chromene-6-carbonitrileCHEMBL12552SCHEMBL231904orb3173908
Database identifiers
- CAS
117545-11-6- PubChem CID
- 60674
Properties
Computed structural properties
- XLogP
- 2.3
- Topological polar surface area
- 53.3 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 1
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 591
Physicochemical properties
- Melting point
- 151 °C · 151 °C
- Boiling point
- 498.4 · 498.4±45.0 °C(Predicted)
- Density
- 1.29 · 1.29±0.1 g/cm3(Predicted)
- pka
- -0.32 · -0.32±0.23(Predicted)
- FDA UNII
- 4 MP5GR4H9L · 4MP5GR4H9L
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Agents that cause an increase in the expansion of a bronchus or bronchial tubes.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
Drugs used to cause dilation of the blood vessels.
Related reactions
1 records
Compound notes
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