Basic information
- CAS
120656-74-8- Standard SMILES
CCC(=O)N(c1ccccc1F)C1(c2ccccc2)CCN(CCn2nnn(CC)c2=O)CC1- InChIKey
RJSCINHYBGMIFT-UHFFFAOYSA-N- Molecular formula
- C25H31FN6O2
- Average molar mass
- 466.6 g/mol
- Monoisotopic mass
- 466.24925241
Overview
Trefentanil (A-3665) is a fentanyl analogue opioid developed in 1992. It is more potent and shorter acting than alfentanil. Trefentanil is not used in clinics due to the severity of its respiratory depression, though it is still used in research.
Names & identifiers
- Preferred name
- Trefentanil
- IUPAC
- N-[1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-4-phenylpiperidin-4-yl]-N-(2-fluorophenyl)propanamide
- English name
- Trefentanil
- Molecular formula
- C25H31FN6O2
- Molecular weight
- 466.55
Names & synonyms
Trefentanil120656-74-836QM58LVGUTREFENTANYLtrefentaniloA-3665 FREE BASEA-3665DTXSID80152955trefentanilumRefChem:190710DTXCID5075446N-(1-(2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl)-4-phenylpiperidin-4-yl)-N-(2-fluorophenyl)propanamide
Show more names
N-(2-Fluorophenyl)-N-[1-[2-[(4-ethyl-5-oxo-1,4-dihydro-5H-tetrazol)-1-yl]ethyl]-4-phenylpiperidin-4-yl]propanamidePropanamide, N-[1-[2-(4-ethyl-4,5-dihydro-5-oxo-1H-tetrazol-1-yl)ethyl]-4-phenyl-4-piperidinyl]-N-(2-fluorophenyl)-
Trefentanil [INN]UNII-36QM58LVGUN-[1-[2-(4-ethyl-5-oxotetrazol-1-yl)ethyl]-4-phenylpiperidin-4-yl]-N-(2-fluorophenyl)propanamideTREFENTANIL [MART.]TREFENTANIL [WHO-DD]CHEMBL84617SCHEMBL397177DB09181
Database identifiers
- CAS
120656-74-8- PubChem CID
- 60728
- DTXSID
DTXSID80152955
Properties
Computed structural properties
- XLogP
- 4.1
- Topological polar surface area
- 71.8 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 8
- Heavy atoms
- 34
- Formal charge
- 0
- Complexity
- 735
Experimental & physicochemical properties
DrugsPharmaceuticals -> Listed in ZINC15
Physicochemical properties
- FDA UNII
- 36 QM58LVGU · 36QM58LVGU
Chemistry & industry
Applications
UsesTrefentanil is a Fentanyl (F274990) derivative, which is used as an analgesic.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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