Basic information
- CAS
78-21-7- Standard SMILES
CCCCCCCCCCCCCCCC[N+]1(CC)CCOCC1.CCOS(=O)(=O)[O-]- InChIKey
QDQHWKZZJJDBND-UHFFFAOYSA-M- Molecular formula
- C22H46NO.C2H5O4S
- Average molar mass
- 465.7 g/mol
- Monoisotopic mass
- 465.3487949
Overview
The CIR Expert Panel concludes that the available data are insufficient to support the safety of Cetethyl Morpholinium Ethosulfate for use in cosmetic products.
Names & identifiers
- Preferred name
- Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate (1:1)
- IUPAC
- 4-ethyl-4-hexadecylmorpholin-4-ium;ethyl sulfate
- English name
- 4-ethyl-4-hexadecylmorpholinium ethyl sulphate
- Molecular formula
- C24H51NO5S
- Molecular weight
- 465.73
Names & synonyms
78-21-7Quaternium-25Atlas G 263Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfateCetethyl morpholinium ethosulfateN-Cetyl-N-ethylmorpholinium ethyl sulfateG 251G 2634-Ethyl-4-hexadecylmorpholinium ethyl sulfateCetyl ethyl morpholinium ethosulfateBARQUAT CMEG-263
Show more names
Barquat(R) CME-35Cetethyl morpholiniumCetyl Morpholinium EthosulfateCETETHYLMORPHOLINIUMETHOSULPHATEcetylethylmorpholinium ethosulfateEthyl-N-hexadecylmorpholinium ethosulfate
4-Ethyl-4-hexadecyl morpholinium ethyl sulfateFU19SYM476NSC-215231Sulfuric acid, monoethyl ester, ion(1-), 4-ethyl-4-hexadecylmorpholiniumMorpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate (1:1)G-251RefChem:124690201-094-8
Database identifiers
- CAS
78-21-7- PubChem CID
- 60971
Properties
Computed structural properties
- Topological polar surface area
- 84 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 5
- Rotatable bonds
- 17
- Heavy atoms
- 31
- Formal charge
- 0
- Complexity
- 364
Experimental & physicochemical properties
Cosmetics
Cosmetic ingredients (Cetethyl Morpholinium Ethosulfate) -> CIR (Cosmetic Ingredient Review)
Emulsifying; Antimicrobial; Hair conditioning; Antistatic; Surfactant
Food Contact Substances
FCS -> FDA Cumulative Estimated Daily Intake (CEDI)
FCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physicochemical properties
- Cosmetics Ingredients Functions
- SURFACTANT - EMULSIFYINGANTIMICROBIALHAIR CONDITIONINGANTISTATICSURFACTANT - CLEANSING
- Cosmetic Ingredient Review (CIR)
- 4 · 4-ethyl-4-hexadecylmorpholinium ethyl sulphate (78-21-7)
- LogP
- 2.201 · 2.201 (est)
- Indirect Additives used in Food Contact Substances
- CETYLETHYLMORPHOLINIUM ETHOSULFATE
- FDA 21 CFR
- 177.226 · 177.2260; 177.2800
- EWG's Food Scores
- 2 · 2-4
- FDA UNII
- 19 SYM476 · FU19SYM476
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P264+P265, P270, P280, P301+P317, P305+P354+P338, P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 594 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate
Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Morpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (100%)
Toxicology
Toxicity Summary
The CIR Expert Panel concludes that the available data are insufficient to support the safety of Cetethyl Morpholinium Ethosulfate for use in cosmetic products.
Ingredients for which the data are insufficient and their use in cosmetics is not supported
Safety data
Chemistry & industry
Uses & manufacturing
UsesCIR ingredient: Cetethyl Morpholinium Ethosulfate
U.S. Production2020: 42,497 lb
Use ClassificationCosmetics -> Emulsifying; Antimicrobial; Hair conditioning; Antistatic; Surfactant
General Manufacturing InformationMorpholinium, 4-ethyl-4-hexadecyl-, ethyl sulfate (1:1): ACTIVE
Applications
Uses4-ethyl-4-hexadecylmorpholinium ethyl sulphate is quaternary ammonium based surfactant that finds uses as superior antistatic, combing and detangling agent in hair conditioning.
Suppliers4 total
陕西缔都医药化工有限公司029-029-81120477 17792793610 · [email protected]
安泰精细化工技术有限公司18503026267 · [email protected]
武汉普世达生物科技有限公司18163336578 · [email protected]
湖北玖天生物医药科技有限公司027-88013699 17354350817 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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