Basic information
- CAS
51-02-5- Standard SMILES
CC(C)NCC(O)c1ccc2ccccc2c1.Cl- InChIKey
QONLGXRPRAIDGI-UHFFFAOYSA-N- Molecular formula
- C15H20ClNO
- Average molar mass
- 265.78 g/mol
- Monoisotopic mass
- 265.123342
Overview
Pronetalol hydrochloride is an organic molecular entity.
Names & identifiers
- Preferred name
- Pronetalol hydrochloride
- IUPAC
- 1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol;hydrochloride
- English name
- 2-Isopropylamino-1-(2-naphthyl)ethanol hydrochloride
- Molecular formula
- C15H20ClNO
- Molecular weight
- 265.78
Names & synonyms
Pronetalol hydrochloridePRONETHALOL HYDROCHLORIDE51-02-52-Isopropylamino-1-(2-naphthyl)ethanol hydrochlorideNethalide hydrochlorideAlderlin hydrochloridePronetalol HClCCRIS 534ICI 38174AY 6204Naphthylisoproterenol hydrochloride020IJC48OF
Show more names
ici38174PronethalolHClalderlinhydrochloride(+/-)-Pronethalol HClnethalidehydrochloridenaphthylisoproterenolhydrochloride1-naphthalen-2-yl-2-(propan-2-ylamino)ethanol hydrochloridealpha-((isopropylamino)methyl)-naphthalenemethanohydrochloride
ICI-38174NSC-758482DTXSID3021194alpha-((Isopropylamino)methyl)-2-naphthalenemethanol hydrochloridealpha-(((1-Methylethyl)amino)methyl)-2-naphthalenemethanol, hydrochloride2-Naphthalenemethanol, alpha-(((1-methylethyl)amino)methyl)-, hydrochloridePRONETHALOL HYDROCHLORIDE [MI]NSC 758482
Database identifiers
- CAS
51-02-5- PubChem CID
- 60975
- DTXSID
DTXSID3021194- ChEMBL
CHEMBL1876082- ChEBI
CHEBI:82525- UNII
- 020IJC48OF
- EC Number
- 809-240-8
Properties
Computed structural properties
- Topological polar surface area
- 32.3 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 18
- Formal charge
- 0
- Complexity
- 229
Experimental & physicochemical properties
Collision Cross Section156.5 Ų [M+H]+ [CCS Type: TW; Method: calibrated with polyalanine and drug standards]
Physicochemical properties
- Melting point
- 184 ° · 184°
- storage temp.
- Store at RT
- form
- Powder
- Water Solubility
- 100 mM · Soluble to 100 mM in water
- FDA UNII
- 20 IJC48OF · 020IJC48OF
- IARC
- 3 · 3 (Vol. 13, Sup 7) 1987
- EPA Substance Registry System
- Pronetalol hydrochloride (51-02-5)
- Symbol(GHS)
- 5 · GHS05,GHS09
- Signal word
- Danger
- Hazard statements
- 318 · H318-H410
- Precautionary statements
- 273 · P273-P391-P501-P280-P305+P351+P338-P310
- Toxicity
- 50 in · LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation]
P264+P265, P273, P280, P305+P354+P338, P317, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesEye Dam. 1 (100%)
Toxicology
Carcinogen Classification
Pronetalol hydrochloride
Group 3: Not classifiable as to its carcinogenicity to humans
Volume 13: (1977) Some Miscellaneous Pharmaceutical Substances
1987
1987
Safety data
- Toxicity
- LD50 in mice (mg/kg): 512 orally, 46 i.v. (Black)
- Signal word
- Danger
- Symbol(GHS)
- GHS05,GHS09
- Hazard statements
- H318-H410
- Precautionary statements
- P273-P391-P501-P280-P305+P351+P338-P310
Chemistry & industry
Applications
UsesPronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].
Suppliers10 total
上海麦克林生化科技股份有限公司021-50706066 15221275939 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
EMMX Biotechnology LLC888-539-0666 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
TargetMol中国（陶术生物）4008200310 15002144251 · [email protected]
陕西缔都医药化工有限公司+86-29-87569266 +86-17392581500 · [email protected]
Additional notes
DefinitionChEBI: Pronetalol hydrochloride is an organic molecular entity.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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