N-(3-Aminopropyl)morpholine (HCID 61055)

Overview

N-aminopropylmorpholine appears as a colorless liquid with a faint, fishlike odor. Burns, but requires some effort to ignite. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.

Names & identifiers

Preferred name: N-(3-Aminopropyl)morpholine
IUPAC: 3-morpholin-4-ylpropan-1-amine
English name: N-(3-Aminopropyl)morpholine
Molecular formula: C7H16N2O
Molecular weight: 144.21

Names & synonyms

123-00-2N-(3-Aminopropyl)morpholine3-Morpholinopropylamine3-morpholinopropan-1-amine4-MORPHOLINEPROPANAMINEN-Aminopropylmorpholine4-(3-Aminopropyl)morpholine3-(morpholin-4-yl)propan-1-amine1-Amino-3-morpholinopropane4-MorpholinepropylamineMorpholine, 4-(3-aminopropyl)-(3-Aminopropyl)morpholine

Show more names

NAPMNSC 10813-MorphoLinopropyLAKOS MSC-0738RARECHEM AL BW 1351LABOTEST-BB LT00731422

3-(4-Morpholinyl)-1-propanamine4-AminopropylmorpholineMorpholine, N-aminopropyl-Morpholine, 4-aminopropyl-3-Morpholinopropanaminegamma-MorpholinopropylamineAminopropylmorpholineN-(3-Aminopropyl)morfolin

Database identifiers

CAS: 123-00-2
PubChem CID: 61055
DTXSID: DTXSID4041521
ChEMBL: CHEMBL158697
ChEBI: CHEBI:86554
UNII: 9A09425QD6
EC Number: 204-590-2
Nikkaji: J34.693D

Properties

Computed structural properties

XLogP: -0.7
Topological polar surface area: 38.5 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 3
Rotatable bonds: 3
Heavy atoms: 10
Formal charge: 0
Complexity: 81.7

Experimental & physicochemical properties

Chemical ClassesCorrosives

SpringerMaterials PropertiesOptical coefficient

Physical Description · 2 items

N-aminopropylmorpholine appears as a colorless liquid with a faint, fishlike odor. Burns, but requires some effort to ignite. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.

CBI

Collision Cross Section128.3 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID4041521]

Physicochemical properties

Melting point: 15 °C · −15 °C(lit.)
Boiling point: 224 °C · 224 °C(lit.)
Density: 0.987 g/mL · 0.987 g/mL at 25 °C(lit.)
vapor density: 4.97 · 4.97
vapor pressure: 11.5 Pa · 11.5Pa at 20℃
refractive index: 20 · n20/D 1.4761(lit.)
Flash point: 210 °F · 210 °F
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: 1000 g/l · 1000g/l
pka: 10.3 · 10.30±0.10(Predicted)
form: Liquid
color: Colorless to Almost colorless
PH: 12 · 12 (H2O, 20℃)
Water Solubility: Soluble
Sensitive: Air Sensitive
BRN: 105104 · 105104
InChI: 1S/C7H16N2O/c8-2-1-3-9-4-6-10-7-5-9/h1-8H2
InChIKey: UIKUBYKUYUSRSM-UHFFFAOYSA-N
SMILES: NCCCN1CCOCC1
LogP: -1.076 at · -1.076 at 20℃ and pH10.81-11.03
Surface tension: 70.3 mN/m · 70.3mN/m at 1g/L and 20℃
Dissociation constant: 10.08 · 10.08
CAS DataBase Reference: 123 · 123-00-2(CAS DataBase Reference)
EWG's Food Scores: 1 · 1
FDA UNII: 9 A09425QD6 · 9A09425QD6
NIST Chemistry Reference: 4 · 4-Morpholinepropanamine(123-00-2)
EPA Substance Registry System: 4 · 4-Morpholinepropanamine (123-00-2)
UNSPSC Code: 12352100 · 12352100
NACRES: 22 · NA.22
Symbol(GHS): 5 · GHS05,GHS07
Signal word: Danger
Hazard statements: 302 · H302-H314
Precautionary statements: 280 · P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes: C,Xi
Risk Statements: 21 · 21-34-21/22-36/37-R34-R21/22
Safety Statements: 26 · 26-36/37/39-45-S45-S36/37/39-S26
RIDADR: 2735 · UN 2735 8/PG 2
WGK Germany: 2 · 2
RTECS: 7700000 · QD7700000
F: 10 · 10-34
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: II
HS Code: 29349990 · 29349990
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 4 OralEye · Acute Tox. 4 OralEye Dam. 1Skin Corr. 1B
Toxicity: 50 orl-rat: · LD50 orl-rat: 3560 mg/kg UCDS** 3/25/70
REACH Registrations: Active
Limited Quantities: 5 L · 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H302 (87.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P260, P264, P264+P265, P270, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 711 reports by companies from 8 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Regulatory Information · 5 items

Chemical: 4-Morpholinepropanamine

4-Morpholinepropanamine is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 4-Morpholinepropanamine are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 07-01-2019 https://echa.europa.eu/registration-dossier/-/registered-dossier/24742

4-Morpholinepropanamine: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelCorrosive

Fire HazardsExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Health HazardsExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Reactive GroupAmines, Phosphines, and Pyridines

Reactivity Profile · 1 item

N-AMINOPROPYLMORPHOLINE behaves as an amine. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

Safety & protection

Fire FightingExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

First AidExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Nonfire Spill ResponseExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Isolation and EvacuationExcerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Personal Protective Equipment (PPE)Excerpt from ERG Guide 153 [Substances - Toxic and/or Corrosive (Combustible)]:

Safety data

F: 10-34
PPE: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
wgk: 2
tsca: TSCA listed
rtecs: QD7700000
ridadr: UN 2735 8/PG 2
hs_code: 29349990
Toxicity: LD50 orl-rat: 3560 mg/kg UCDS** 3/25/70
risk_code: 21-34-21/22-36/37-R34-R21/22
Signal word: Danger
Symbol(GHS): GHS05,GHS07
hazard_code: C,Xi
safety_code: 26-36/37/39-45-S45-S36/37/39-S26
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: II
Hazard statements: H302-H314
Limited Quantities: 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities: Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
REACH Registrations: Active
Hazard Classifications: Acute Tox. 4 OralEye Dam. 1Skin Corr. 1B
Precautionary statements: P280-P301+P312+P330-P301+P330+P331-P303+P361+P353-P305+P351+P338+P310

Chemistry & industry

Uses & manufacturing

U.S. Production2023: <75,000 lb

Consumer UsesSemiconductor and photovoltaic agent

Household ProductsInformation on 1 consumer products that contain N-Aminopropylmorpholine in the following categories is provided:

General Manufacturing Information4-Morpholinepropanamine: ACTIVE

Applications · 3 items

UsesFiber synthesis; chemical intermediate.

Uses3-(4-Morpholinyl)propylamine is catalytic agent, petrochemical additive. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.

General DescriptionA colorless liquid with a faint, fishlike odor. Burns, but requires some effort to ignite. Corrosive to tissue. Produces toxic oxides of nitrogen during combustion.

Upstream & downstream products

Upstream raw materials

N-(3-Morpholinopropyl)phthalimide 4-Morpholinepropanamine, N-[3-(4-morpholinyl)propyl]-4-(3-Chloropropyl)morpholine 3-(4-Morpholino)propionitrile 1-(3-Aminopropyl)pyrrolidine N-(3-Chloropropyl)phthalimide 3-Chloropropylamine hydrochloride N-(3-Bromopropyl)phthalimide Azetidine Morpholine Benzophenone Potassium phthalimide

Downstream products

N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine 4-Morpholinepropanamine, N-cyclopentyl-4-(3-(4-Chloro-5,6-dimethyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)propyl)morpholine 2-Amino-N-(3-morpholin-4-ylpropyl)benzamide (2-Chloro-benzyl)-(3-morpholin-4-yl-propyl)-amine

Suppliers50 total

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

武汉欣扬瑞和化学科技有限公司13720274133 · [email protected]

湖北金梭生物科技有限公司00123456789 · [email protected]

Additional notes

DefinitionChEBI: A member of the class of morpholines that is morpholine substituted by a 3-aminopropyl group a the N atom.

Related reactions

289 records

New reaction record

HRID 3188As reactantuspto-grants-1998_03

HRID 3442As reactantuspto-grants-1998_03

HRID 12355As reactantuspto-grants-2010_06

HRID 21785As productuspto-grants-1995_06

HRID 24604As reactantuspto-grants-2005_02

HRID 25207As reactantuspto-grants-2005_02

HRID 38845As reactantuspto-grants-2013_09

HRID 39541As reactantuspto-grants-2013_09

Linked notes

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Basic information