Hydrazine → N-(3-Aminopropyl)morpholine

HRID 21785

Reaction equation

HRID 21785 reaction equation
[NH2:1]N.[N:3]1([CH2:9][CH2:10][CH2:11]C2C=CC=C3C(NC(=O)C=23)=O)[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1>CO>[N:3]1([CH2:9][CH2:10][CH2:11][NH2:1])[CH2:4][CH2:5][O:6][CH2:7][CH2:8]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 1317183813-Morpholinylpropylphthalimide

Product 1

HCID 61055N-(3-Aminopropyl)morpholine

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Hydrazine (aqueous solution at 35% by wt.) (0.15 ml; 1.6 mmoles) was added to 3-morpholinylpropylphthalimide (219 mg; 0.8 mmoles) in methanol (5 ml) and the resulting solution was refluxed. Reaction times and process as per Example 1.

Workup

  1. temperaturethe resulting solution was refluxed
  2. customReaction times and process as per Example 1

Sources & evidence

ORD record
ord-31cf6c6cd592407aaa6aa050e8dff730
Source dataset
uspto-grants-1995_06
Patent number
US05424451

Linked notes

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