Basic information
- CAS
1758-73-2- Standard SMILES
N=C(N)S(=O)O- InChIKey
FYOWZTWVYZOZSI-UHFFFAOYSA-N- Molecular formula
- CH4N2O2S
- Average molar mass
- 108.12 g/mol
- Monoisotopic mass
- 107.99934837
Overview
Thiourea dioxide appears as a white or light-yellow odorless crystalline powder. Mp:126 °C. Soluble in water (27 g / L at room temperature). Decomposes exothermically at temperatures above 126 °C with the emission of noxious gases (sulfur oxides, ammonia, carbon monoxide, nitrogen oxides and hydrogen sulfide) and carbon dioxide. Extended exposure to temperatures above 50 °C and moisture may cause visible decomposition. Irritating to skin and mucous membranes. Corrosive to eye tissue. Used in leather processing, the paper industry, photographic industry, and in textile processing as a bleaching agent.
Names & identifiers
- Preferred name
- Thiourea dioxide
- IUPAC
- amino(imino)methanesulfinic acid
- English name
- Thiourea dioxide
- Molecular formula
- CH4N2O2S
- Molecular weight
- 108.12
Names & synonyms
Thiourea dioxide1758-73-2Formamidinesulfinic acidManofastFormamidine sulfinic acidAMINOIMINOMETHANESULFINIC ACIDNSC 34540NSC 22697942BWR07L73NSC-34540NSC-226979RefChem:897984
Show more names
Thiurea dioxideThiourea S,S-dioxideFORMAMIDINESULPHINIC ACIDaminoimino-methanesulfinicaciFASTECHAmino(imino)FAS PRIMER PAIRTiourea dioxide
217-157-8amino(imino)methanesulfinic acidcarbamimidoylsulfinic acidAminoiminomethanesulphinic acidAIMSAMethanesulfinic acid, 1-amino-1-imino-Methanesulfinic acid, aminoimino-formamidine sulfuric acid
Database identifiers
- CAS
1758-73-2、4189-44-0- PubChem CID
- 61274
- DTXSID
DTXSID4029224- UNII
- 42BWR07L73
- EC Number
- 217-157-8
- Nikkaji
- J1.000.659G
Properties
Computed structural properties
- XLogP
- -1.1
- Topological polar surface area
- 106 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 1
- Heavy atoms
- 6
- Formal charge
- 0
- Complexity
- 89.5
Experimental & physicochemical properties
Physical Description
Thiourea dioxide appears as a white or light-yellow odorless crystalline powder. Mp:126 °C. Soluble in water (27 g / L at room temperature). Decomposes exothermically at temperatures above 126 °C with the emission of noxious gases (sulfur oxides, ammonia, carbon monoxide, nitrogen oxides and hydrogen sulfide) and carbon dioxide. Extended exposure to temperatures above 50 °C and moisture may cause visible decomposition. Irritating to skin and mucous membranes. Corrosive to eye tissue. Used in leather processing, the paper industry, photographic industry, and in textile processing as a bleaching agent.
Dry Powder
Physicochemical properties
- Melting point
- 124 · 124-127 °C (dec.)(lit.)
- Boiling point
- 355.3 · 355.3±25.0 °C(Predicted)
- Density
- 1.68 · 1.68
- bulk density
- 850 kg/m3 · 850kg/m3
- vapor pressure
- 0 Pa · 0Pa at 25℃
- refractive index
- 1.655 · 1.6550 (estimate)
- storage temp.
- 2 · 2-8°C
- solubility
- 27 g/l · 27g/l
- form
- Crystalline Powder
- pka
- 2.4 · 2.40±0.10(Predicted)
- color
- White
- PH
- 4 · 4 (10g/l, H2O, 20℃)
- Water Solubility
- 30 g/L · 30 g/L (20 ºC)
- Sensitive
- Moisture Sensitive
- BRN
- 506653 · 506653
- Cosmetics Ingredients Functions
- REDUCING
- InChI
- 1S/CH4N2O2S/c2-1(3)6(4)5/h(H3,2,3)(H,4,5)
- InChIKey
- FYOWZTWVYZOZSI-UHFFFAOYSA-N
- SMILES
- NC(=N)S(O)=O
- LogP
- -3.37 at · -3.37 at 25℃
- CAS DataBase Reference
- 1758 · 1758-73-2(CAS DataBase Reference)
- FDA UNII
- 42 BWR07L73 · 42BWR07L73
- EPA Substance Registry System
- Methanesulfinic acid, aminoimino- (1758-73-2)
- UNSPSC Code
- 12352106 · 12352106
- NACRES
- 22 · NA.22
- Symbol(GHS)
- 2 · GHS02,GHS05,GHS06,GHS08
- Signal word
- Danger
- Hazard statements
- 251 · H251-H302-H315-H318-H330-H335-H373
- Precautionary statements
- 235 · P235-P280-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P314
- target organs
- Lungs, Respiratory system
- PPE
- 95 · dust mask type N95 (US), Eyeshields, Gloves
- Hazard Codes
- Xn,Xi
- Risk Statements
- 5 · 5-22-36/37/38
- Safety Statements
- 26 · 26-24/25-36
- RIDADR
- 3341 · UN 3341 4.2/PG II/III (THIOUREA DIOXIDE)
- WGK Germany
- 1 · 1
- RTECS
- 372500 · PB0372500
- TSCA
- TSCA listed
- HazardClass
- 4.2 · 4.2
- PackingGroup
- II
- HS Code
- 29309070 · 29309070
- Storage Class
- 4.2 · 4.2 - Pyrophoric and self-heating hazardous materials
- Hazard Classifications
- 2 InhalationAcute · Acute Tox. 2 InhalationAcute Tox. 4 OralEye Dam. 1Self-heat. 1Skin Irrit. 2STOT RE 2STOT SE 3
- REACH Registrations
- Active
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 2.4% (4 of 164) of reports.
Danger
H251 (59.8%): Self-heating; may catch fire [Danger Self-heating substances and mixtures]
P235, P260, P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, P407, P410, P413, P420, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 164 reports by companies from 25 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Danger
Hazard information
Regulatory Information
Chemical: Methanesulfinic acid, aminoimino-
Methanesulfinic acid, 1-amino-1-imino- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methanesulfinic acid, 1-amino-1-imino- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 17-06-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/8595
Thiourea dioxide: HSNO Approval: HSR001431 Approved with controls
Other Safety InformationIMAP assessments - Methanesulfinic acid, aminoimino-: Human health tier II assessment
DOT LabelSpontaneously Combustible
Fire Hazards
Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:
· Flammable/combustible material.
Health Hazards
Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:
· Fire will produce irritating, corrosive and/or toxic gases.
DOT ID and Guide3341 135
Reactive GroupAmides and Imides
Reactivity AlertsPyrophoric
Reactivity Profile
Thiourea dioxide is a reducing agent and a derivative of sulfinic acid (a weak inorganic acid). Decolorizes and bleaches materials by chemical reduction. Stable under normal temperatures and pressures. May decompose on exposure to moist air or water. Incompatible with strong oxidizing agents, strong bases. Aqueous solutions are acidic and corrosive.
DOT Hazard Classification
Thiourea dioxide
UN3341
Div 4.2 Spontaneously combustible material (49 eCFR § 173.124)
PG II: the degree of danger presented by the material is medium
Air and Water ReactionsSoluble in water. May decompose on exposure to moist air or water.
Hazard Classes and Categories
Self-heat. 1 (59.8%)
Eye irritation - category 2A
Self-heating substances and mixtures - Category 1
Safety & protection
Fire FightingExcerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:
Accidental Release Measures
· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.
· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.
First Aid
Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:
General First Aid:
Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).
Nonfire Spill ResponseExcerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:
Isolation and Evacuation
Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:
Immediate precautionary measure
Personal Protective Equipment (PPE)Excerpt from ERG Guide 135 [Substances - Spontaneously Combustible]:
Emergency Response Planning Guidelines· DO NOT USE WATER, CO2 OR FOAM ON MATERIAL ITSELF.
Safety data
- PPE
- dust mask type N95 (US), Eyeshields, Gloves
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- PB0372500
- ridadr
- UN 3341 4.2/PG II/III (THIOUREA DIOXIDE)
- hs_code
- 29309070
- risk_code
- 5-22-36/37/38
- Signal word
- Danger
- Symbol(GHS)
- GHS02,GHS05,GHS06,GHS08
- hazard_code
- Xn,Xi
- safety_code
- 26-24/25-36
- hazard_class
- 4.2
- Storage Class
- 4.2 - Pyrophoric and self-heating hazardous materials
- packing_group
- II
- target organs
- Lungs, Respiratory system
- Hazard statements
- H251-H302-H315-H318-H330-H335-H373
- Excepted Quantities
- Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)
- REACH Registrations
- Active
- Hazard Classifications
- Acute Tox. 2 InhalationAcute Tox. 4 OralEye Dam. 1Self-heat. 1Skin Irrit. 2STOT RE 2STOT SE 3
- Precautionary statements
- P235-P280-P301+P312+P330-P304+P340+P310-P305+P351+P338+P310-P314
Chemistry & industry
Uses & manufacturing
U.S. Production2023: 350,722 lb
Consumer UsesNot Known or Reasonably Ascertainable
Industry UsesBleaching agent
General Manufacturing Information
Not Known or Reasonably Ascertainable
Methanesulfinic acid, 1-amino-1-imino-: ACTIVE
Applications
UsesConvenient reagent for the reduction of ketones to secondary alcohols. Thiourea dioxide is an effective bleach when used alone or when used after hydrogen peroxide in a full bleaching process (Duffield, 1986; Cegarra et al, 1988). Bleaching with thiourea dioxide is not common practice but it is effective when used alone, and the process compares favorably with hydrogen peroxide bleaching. A formulation can include a commercial thiourea dioxide product, wetting agent and EDTA sequestering agent. Reductive bleaching is carried out at pH 7.0 at 70°C for 60 min (Duffield, 1986).
General DescriptionA white or light-yellow odorless crystalline powder. Mp:126°C. Soluble in water (27 g / L at room temperature). Decomposes exothermically at temperatures above 126°C with the emission of noxious gases (sulfur oxides, ammonia, carbon monoxide, nitrogen oxides and hydrogen sulfide) and carbon dioxide. Extended exposure to temperatures above 50°C and moisture may cause visible decomposition. Irritating to skin and mucous membranes. Corrosive to eye tissue. Used in leather processing, the paper industry, photographic industry, and in textile processing as a bleaching agent.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
衢州润东化工有限公司0570-8789886 18892685668 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
山东艾利特生物科技有限公司0539-18853986-090 13053958157 · [email protected]
河北创海生物科技有限公司+86-86-13131129325 · [email protected]
河北展药生物科技有限公司15369953316 +8615369953316 · [email protected]
Hebei Yanxi Chemical Co., Ltd.+86-17531190177 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]
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上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
山东洛克化工有限公司17653113209 13065062079 · [email protected]
合肥天健化工有限公司551-65418679 15856988503;15837135945 · [email protected]
孝感深远化工有限公司15527621225; 15527621225 · [email protected]
山东西亚化学有限公司13355009207 13355009207 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
天津希恩思生化科技有限公司400 638 7771 · [email protected]
河南多贝化工有限公司0370-2785118 17550508557 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
艾科试剂4008-755-333 18080918076 · [email protected]
上海思域化工科技有限公司86-21-34053660 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
上海健超生物科技有限公司150-2103-5486 18017383231 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
上海贤鼎生物科技有限公司4009209199 · [email protected]
河北傲格化工有限公司0310-4915333 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
上海将来实业股份有限公司021-61552785 · [email protected]
安徽科迪达化工有限公司0554-2106669 · [email protected]
HBCChem, Inc.+1-510-219-6317 · [email protected]
日照力德士化工有限公司010-51268198 · [email protected]
美岚实业（上海）有限公司021-58958189 · [email protected]
上海爱蝶实业有限公司021-58957966 18930537195 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
广拓化学（上海）有限公司021-60899189-8001 18918189673 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
上海有朋化工有限公司021-69005955 13701776567 · [email protected]
上海凯赛化工有限公司021-33516722 13701817765 · [email protected]
上海彤源化工有限公司021-021-69182866 13701855675 · [email protected]
上海孚一生物科技有限公司+86 (21) 61124340
上海兴鲁化工科技有限公司02120970332 · [email protected]
上海容立化学科技有限公司021-69992220 13701886816 · [email protected]
上海康拓化工有限公司021-69185552 13701777608 · [email protected]
湖北巨胜科技有限公司027-59599241 18871490274 · [email protected]
常州百涛实业有限公司0519-82309982
Related reactions
23 records
Compound notes
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