Basic information
- CAS
76472-87-2- Standard SMILES
CC(C)=CCc1c(O)ccc(C(=O)C2C(c3c(O)cc(O)c4c(=O)c(CC=C(C)C)c(-c5ccc(O)cc5O)oc34)C=C(C)CC2c2ccc(O)cc2O)c1O- InChIKey
DKBPTKFKCCNXNH-UHFFFAOYSA-N- Molecular formula
- C45H44O11
- Average molar mass
- 760.8 g/mol
- Monoisotopic mass
- 760.28836222
Overview
See also: Kuwanon H (annotation moved to).
Names & identifiers
- Preferred name
- Moracenin a
- IUPAC
- 8-[6-[2,4-dihydroxy-3-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methylcyclohex-2-en-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methylbut-2-enyl)chromen-4-one
- English name
- kuwanon H
- Molecular formula
- C45H44O11
- Molecular weight
- 760.82
Names & synonyms
moracenin aKuwanon H [M+H]+SCHEMBL13233442SCHEMBL29540653BDBM646494US20240024403, Compound Albaninkuwanon HAlvanin GAlbanin Gkuwanone HNSC 356889Inhibitor,Kuwanon H,Bombesin Receptor,inhibit
Show more names
8-[(1S,5R,6S)-6-[2,4-dihydroxy-3-(3-methylbut-2-enyl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methyl-1-cyclohex-2-enyl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methylbut-2-enyl)chromen-4-one8-[(1S)-6α-[2,4-Dihydroxy-3-(3-methyl-2-butenyl)benzoyl]-5β-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1β-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one4H-1-Benzopyran-4-one, 8-[(1S,5R,6S)-6-[2,4-dihydroxy-3-(3-methyl-2-buten-1-yl)benzoyl]-5-(2,4-dihydroxyphenyl)-3-methyl-2-cyclohexen-1-yl]-2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-3-(3-methyl-2-buten-1-yl)-
Database identifiers
- CAS
Properties
Computed structural properties
- XLogP
- 9.2
- Topological polar surface area
- 205 Ų
- Hydrogen bond donors
- 8
- Hydrogen bond acceptors
- 11
- Rotatable bonds
- 9
- Heavy atoms
- 56
- Formal charge
- 0
- Complexity
- 1,560
Physicochemical properties
- storage temp.
- -20 °C · Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- Yellow to orange
- FDA UNII
- 822 Q5M4B5D · 822Q5M4B5D
Chemistry & industry
Pharmacology
Cellular LocationsMembrane
Applications
UsesKuwanon H is a flavonoid isolated from Morus alba, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1].
Suppliers76 total
陕西缔都医药有限责任公司029-81124775 17791530730 · [email protected]
南京世洲生物科技有限公司025-85560043 15850508050 · [email protected]
成都乐美天医药科技有限公司17308096051 17308096051 · [email protected]
Career Henan Chemica Co+86-0371-86658258 +86-13203830695 · [email protected]
上海纯优生物科技有限公司15921393123 18302135232 · [email protected]
成都埃法生物科技有限公司028-028-85142057 19983342022 · [email protected]
成都彼样生物科技有限公司18108052721 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]
成都市久鼎化学技术有限公司18584079237 · [email protected]
上海毕得医药科技股份有限公司
Related reactions
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Compound notes
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