4-Hydroxyurapidil
Basic information
- CAS
88733-12-4- Standard SMILES
COc1cc(O)ccc1N1CCN(CCCNc2cc(=O)n(C)c(=O)n2C)CC1- InChIKey
WQYQEWKEJSPSCM-UHFFFAOYSA-N- Molecular formula
- C20H29N5O4
- Average molar mass
- 403.5 g/mol
- Monoisotopic mass
- 403.22195442
Overview
urapidil metabolite
Names & identifiers
- Preferred name
- 4-Hydroxyurapidil
- IUPAC
- 6-[3-[4-(4-hydroxy-2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
- English name
- 4-hydroxyurapidil
- Molecular formula
- C20H29N5O4
- Molecular weight
- 403.48
Names & synonyms
4-Hydroxyurapidil88733-12-4para-HydroxyurapidilDTXSID00237278RefChem:99424DTXCID001597694-Hydroxy Urapidil6-[3-[4-(4-hydroxy-2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione6-((3-(4-(4-Hydroxy-2-methoxyphenyl)piperazin-1-yl)propyl)amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dionep-Hydroxy Urapidil6-({3-[4-(4-Hydroxy-2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4(1H,3H)-dioneD297JT38AS
Show more names
Urapidil impurity 5para-Hydroxy Urapidil
WQYQEWKEJSPSCM-UHFFFAOYSA-N6-[3-[4-(2-Methoxy-4-hydroxyphenyl)piperazinyl]propylamino]-1,3-dimethyluracil2,4(1H,3H)-Pyrimidinedione, 6-[[3-[4-(4-hydroxy-2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-6-((3-[4-(4-Hydroxy-2-methoxyphenyl)-1-piperazinyl]propyl)amino)-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione #6-[[3-[4-(4-Hydroxy-2-methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyl-2,4(1H,3H)-pyrimidinedione
Database identifiers
- CAS
88733-12-4- PubChem CID
- 614447
- DTXSID
DTXSID00237278- UNII
- D297JT38AS
- Nikkaji
- J357.905K
Properties
Computed structural properties
- XLogP
- 1.2
- Topological polar surface area
- 88.6 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 7
- Heavy atoms
- 29
- Formal charge
- 0
- Complexity
- 620
Chemistry & industry
Applications
Uses4-Hydroxy Urapidil is the p-hydrohlyated analogue and M1 metabolite of Urapidil (U815400). In comparison to Uradipil, 4-Hydroxy Urapidil is a 10-fold less potent hypotensive agent and lacks a central effect.
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Related reactions
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Compound notes
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