Basic information
- CAS
10138-52-0- Standard SMILES
[Cl][Gd]([Cl])[Cl]- InChIKey
MEANOSLIBWSCIT-UHFFFAOYSA-K- Molecular formula
- Cl3Gd
- Average molar mass
- 263.6 g/mol
- Monoisotopic mass
- 262.83067
Overview
Gadolinium trichloride is a gadolinium coordination entity. It has a role as a TRP channel blocker.
Names & identifiers
- Preferred name
- Gadolinium chloride
- IUPAC
- trichlorogadolinium
- English name
- GADOLINIUM CHLORIDE
- Molecular formula
- Cl3Gd
- Molecular weight
- 263.61
Names & synonyms
GADOLINIUM CHLORIDE10138-52-0Gadolinium trichloridegadolinium(III) chlorideGadolinium chloride (GdCl3)CHEBI:37288P7082WY76DNSC-174322RefChem:607880DTXCID0024761233-386-6DTXSID2044761
Show more names
GdCl3NSC 174322inium(III) chL4-dihydrocoumarinGadm(lll) chlorideTrichlorogadoliniumgadoliniumtrichloridegadoliniumchloride(gdcl3)
GdCl3.xH2O[GdCl3]gadolinium(3+) chlorideTrichlorogadolinium hydrateWLN: GD G3Gadolinium trichloride hydrateGadolinium(III)chloride hydrateEINECS 233-386-6
Database identifiers
- CAS
10138-52-0- PubChem CID
- 61486
- ChEBI
CHEBI:37288- EC Number
- 233-386-6
Properties
Computed structural properties
- Topological polar surface area
- 0 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 0
- Rotatable bonds
- 0
- Heavy atoms
- 4
- Formal charge
- 0
- Complexity
- 8
Experimental & physicochemical properties
Chemical ClassesMetals -> Rare Earth Metals
SpringerMaterials Propertiesdielectric constant
Physical DescriptionWhite crystals; Soluble in water; [Merck Index]
Physicochemical properties
- Melting point
- 609 °C · 609°C
- Density
- 4 · 4,52 g/cm3
- storage temp.
- Hygroscopic, Room Temperature, under inert atmosphere
- solubility
- Water
- form
- powder
- color
- White to off-white
- Specific Gravity
- 4.52 · 4.52
- Water Solubility
- Soluble in water.
- Specific Heat Capacity
- 0.33 J/ · Cp(crystal): 0.33 J/(g·K), at 25℃
- Sensitive
- Hygroscopic
- Crystal Structure
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 2.1% (1 of 48) of reports.
Warning
H315 (97.9%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P264+P265, P280, P302+P352, P305+P351+P338, P321, P332+P317, P337+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 48 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazards SummarySee Gadolinium. See RARE EARTH METALS and the linked occupational diseases.
Hazard Classes and CategoriesSkin Irrit. 2 (97.9%)
Toxicology
Adverse EffectsFibrogenic - Inducing tissue injury and fibrosis (scarring).
Safety data
- F
- 10-21
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- ZC0230000
- hs_code
- 28273985
- risk_code
- 38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 36/37
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances that reduce or suppress INFLAMMATION.
Substances used to allow enhanced visualization of tissues.
Uses & manufacturing
UsesUsed to make gadolinium sponge metal; [Hawley]
General Manufacturing InformationGadolinium chloride (GdCl3): ACTIVE
Applications
UsesGadolinium(III) Chloride is used as chelating agents, which is essential for biomedical applications. It is also employed in the synthesis and nuclear magnetic resonance (NMR) studies of paramagnetic GdPCTA-[12] and GdPCTA-[13] complexes. It plays an important role as contrast agent for magnetic resonance imaging and an macrophage inhibitor.
UsesGadoliniuM chloride, anhydrous is a calcium-sensing receptor agonist and is known to work by inducing NLRP3 inflammasome activation in bone marrow-derived macrophages. GdCl3 is used for preparing gadolinium metal.
Preparation methods
PreparationGdCl3 is prepared by heating gadolinium(III) oxide with excess of ammonium chloride above 200°C: Gd2O3 + 6NH4Cl→2GdCl3 + 6NH3 + 3H2O
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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