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Basic information
- CAS
10198-40-0- Standard SMILES
[60Co]- InChIKey
GUTLYIVDDKVIGB-OUBTZVSYSA-N- Molecular formula
- Co
- Average molar mass
- 59.9338 g/mol
- Monoisotopic mass
- 59.9338171
Overview
Cobalt Co-60 is under investigation in clinical trial NCT02891083 (Adjuvant Therapies or Surgery Alone for High Risk pN0 Esophageal Cancer).
Names & identifiers
- Preferred name
- Cobalt-60
- IUPAC
- cobalt-60
- English name
- cobalt
- Molecular formula
- Co
- Molecular weight
- 58.93
Names & synonyms
Cobalt-60Cobalt Co-6060Co radioisotope10198-40-0Co-60 radioisotope60CoCobalt, isotope of mass 605C8182XDPZ(60Co)cobaltRefChem:127209COBALT 60UNII-5C8182XDPZ
Show more names
Co-6060mCo isotope60Co isotopeIsotope:60mCoIsotope:60CoCobalt-60m60mCo (isotope)Cobalt-60 isotope
Database identifiers
- CAS
10198-40-0- PubChem CID
- 61492
- DTXSID
DTXSID80891751- UNII
- 5C8182XDPZ
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 0 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 0
- Rotatable bonds
- 0
- Heavy atoms
- 1
- Formal charge
- 0
- Complexity
- 0
Experimental & physicochemical properties
Chemical ClassesPhysical/Radiation -> Radionuclides
Physical DescriptionSilver-white metal;
Physicochemical properties
- Density
- 2.05 E-3 · 2.05E-3 g/cm3
- FDA UNII
- 5 C8182XDPZ · 5C8182XDPZ
- EPA Substance Registry System
- -60 · Cobalt-60 (10198-40-0)
- RIDADR
- 3332 · 3332
- HazardClass
- 7 · 7
- PackingGroup
- II
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Hazard information
Hazards Summary
Source: Neutron activation of stable Co-59; Half-Life: 5.3 years Effective Half-Life: 10 days Specific Activity: 1,100 Ci/g Decay Mode: Beta GI Absorption: 5-30% Lung Clearance Half-Time: >100 days for oxides, hydroxides, halides, and nitrates; 10-100 days for other compounds; Critical Organ: Total body Internal Toxicity: High Annual Limit on Intake: 0.030 mCi Tenth-Value Layer: 34.8 mm Pb Gamma Ray Constant: 13.2 R/h @ 1 cm per mCi Radiation Energy (MeV): Beta 0.313 (99.8%); Gamma 1.17 (99.8%); Gamma 1.33 (100%) Radiation Accidents: 31 accidents reported with 211 injuries and 30 deaths plus C0-60 was involved in 16 incidents of Melting of Radioactive Materials; [See Glossary for references.] See Radiation, ionizing.
DOT Hazard Classification
Cobalt-60
Radioactive material
Atomic number: 27
Cobalt-60m
Radioactive material
Atomic number: 27
Safety & protection
Exposure Control and Personal ProtectionBiological Exposure Indices (BEI) [ACGIH] - Cobalt in urine = 15 ug/L; sample at end of shift at end of workweek;
Minimum Risk LevelChronic Inhalation: 0.0001 mg/m3 (L134)
Intermediate Oral: 0.01 mg/kg/day (L134)
Acute Radiation: 4 mSv (L134)
Chronic Radiation: 1 mSv/yr (L134)
Toxicology
TreatmentTreatment of cobalt poisoning is symptomatic. (L29)
Health Effects
Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitus. Cobalt may also have mutagenic and carcinogenic effects. Exposure to cobalt radiation causes cell damage and can lead to severe burns and death at high doses. (L29, L30)
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)
Uses & manufacturing
Uses
Cobalt-59 is the naturally occurring stable form of cobalt. Of the 9 major radioactive isotopes, only Co-57 and Co-60 have half-lives longer than 80 days. Cobalt-60 is formed by neutron activation in nuclear reactors and particle accelerators. [Argonne] Co-60 is used in medicine for instrument sterilization and radiation therapy for cancer; Used in industrial radiography and irradiation of food and grain; [Waltar, Appendix A-D]
Radioactive cobalt is used for commercial and medical purposes, such as for sterilizing medical equipment and consumer products, radiation therapy for treating cancer patients, manufacturing plastics, and irradiating food. (L29)
Applications
Uses60Co (cobalt-60), a gamma and beta ray emitter with a half-life of about 5.3 years, is used in cancer therapy. Small pieces of radioactive metallic cobalt, made radioactive in a nuclear reactor, are placed into a proper shielding device and the radiation from them used in place of a high-powered x-ray machine or radium implantations in treating patients with localized cancer.
Suppliers1 total
时美拓特种气体（上海）有限公司18557025385 15757158480 · [email protected]
Related reactions
1 records
Compound notes
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