CAS 10326-41-7 D-Lactic Acid (HCID 61503)

Overview

(R)-lactic acid is an optically active form of lactic acid having (R)-configuration. It has a role as an Escherichia coli metabolite and a human metabolite. It is a conjugate acid of a (R)-lactate. It is an enantiomer of a (S)-lactic acid.

Names & identifiers

Preferred name: D-Lactic Acid
IUPAC: (2R)-2-hydroxypropanoic acid
English name: (R)-Lactate
Molecular formula: C3H6O3
Molecular weight: 90.08

Names & synonyms

D-Lactic acid10326-41-7(R)-2-Hydroxypropanoic acidD-(-)-Lactic acid(2R)-2-hydroxypropanoic acid(R)-Lactic acid(-)-Lactic acidPropanoic acid, 2-hydroxy-, (2R)-(R)-2-Hydroxypropionic acid(R)-(-)-Lactic acidD-MilchsaeureD-2-Hydroxypropanoic acid

Show more names

D-MILK ACID(r)-lactateD-（& # 8722D-LaCLic Acid(R)-lacticaciD(-)LACTIC ACID

Lactic acid, D-D-2-Hydroxypropionic acid(R)-alpha-Hydroxypropionic acidDTXSID00470303Q6M5SET7WDTXCID8027030CHEBI:42111RefChem:584137

Database identifiers

CAS: 10326-41-7
PubChem CID: 61503
DTXSID: DTXSID0047030
ChEMBL: CHEMBL358850
ChEBI: CHEBI:42111
UNII: 3Q6M5SET7W
EC Number: 233-713-2
Nikkaji: J9.141C

Properties

Computed structural properties

XLogP: -0.7
Topological polar surface area: 57.5 Å²
Hydrogen bond donors: 2
Hydrogen bond acceptors: 3
Rotatable bonds: 1
Heavy atoms: 6
Formal charge: 0
Complexity: 59.1

Experimental & physicochemical properties

SpringerMaterials PropertiesCoriolis coupling

Melting Point52.8 °C

Physical DescriptionSolid

Dissociation Constants · 2 items

3.861

3.83

Physicochemical properties

Melting point: 52.8 ° · 52.8°
alpha: 54621.5 · 54621.5 -2.6° (c = 8)
Boiling point: 227.6 · 227.6±0.0 °C(Predicted)
Density: 1.276 · 1.276±0.06 g/cm3(Predicted)
vapor pressure: 3.8 Pa · 3.8Pa at 25℃
refractive index: 1.428 to · 1.4280 to 1.4320
FEMA: 2611 · 2611 | LACTIC ACID
storage temp.: -20 °C · -20°C
solubility: 2 O: · H2O: 0.1 g/mL, clear, colorless
form: Low Melting Solid
pka: 3.83 · pK = 3.83(at 25℃)
color: White to Off-white
Odor: odorless acidic
optical activity: 7.0675 ° · 7.0675°(C=1g/100ml H2O)
Water Solubility: Soluble in water (50mg/ml)
Merck: 14 · 14,5335
JECFA Number: 930 · 930
BRN: 1720252 · 1720252
Stability: Hygroscopic
InChI: 1S/C3H6O3/c1-2(4)3(5)6/h2,4H,1H3,(H,5,6)/t2-/m1/s1
InChIKey: JVTAAEKCZFNVCJ-UWTATZPHSA-N
SMILES: C[C@@H](O)C(O)=O
LogP: -0.54 at · -0.54 at 20℃
CAS DataBase Reference: 10326 · 10326-41-7(CAS DataBase Reference)
SCOGS (Select Committee on GRAS Substances): D(-)-Lactic acid
FDA UNII: 3 Q6M5SET7W · 3Q6M5SET7W
EPA Substance Registry System: 2 · Propanoic acid, 2-hydroxy-, (2R)- (10326-41-7)
UNSPSC Code: 12352201 · 12352201
NACRES: 25 · NA.25
Symbol(GHS): 5 · GHS05
Signal word: Danger
Hazard statements: 315 · H315-H318
Precautionary statements: 264 · P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364
PPE: 95 · dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes: Xi
Risk Statements: 38 · 38-41
Safety Statements: 26 · 26-39
RIDADR: 3265 · UN 3265 8/PG III
WGK Germany: 3 · 3
F: 3 · 3-10
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: III
HS Code: 2918110000 · 2918110000
Storage Class: 8 A · 8A - Combustible corrosive hazardous materials
Hazard Classifications: 1 Skin · Eye Dam. 1Skin Corr. 1C
REACH Registrations: Active

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H314 (10.4%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P264+P265, P280, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P332+P317, P362+P364, P363, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 48 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

Hazard information

Regulatory Information · 4 items

Chemical: Propanoic acid, 2-hydroxy-, (2R)-

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 22-09-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/12317

Propanoic acid, 2-hydroxy-, (2R)-: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationEvaluation - Lactic acid isomers

Hazard Classes and Categories · 2 items

Skin Corr. 1C (10.4%)

Skin corrosion/irritation - Category 1

Toxicology

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).

Safety data

F: 3-10
PPE: dust mask type N95 (US), Eyeshields, Gloves
wgk: 3
tsca: TSCA listed
ridadr: UN 3265 8/PG III
hs_code: 2918110000
risk_code: 38-41
Signal word: Danger
Symbol(GHS): GHS05
hazard_code: Xi
safety_code: 26-39
hazard_class: 8
Storage Class: 8A - Combustible corrosive hazardous materials
packing_group: III
Hazard statements: H315-H318
REACH Registrations: Active
Hazard Classifications: Eye Dam. 1Skin Corr. 1C
Precautionary statements: P264-P280-P302+P352-P305+P351+P338-P332+P313-P362+P364

Chemistry & industry

Pharmacology

Tissue LocationsBladder

Cellular LocationsExtracellular

Metabolite PathwaysLeigh Syndrome

Uses & manufacturing

UsesThis is an endogenously produced metabolite found in the human body. It is used in metabolic reactions, catabolic reactions or waste generation.

General Manufacturing InformationPropanoic acid, 2-hydroxy-, (2R)-: ACTIVE

Applications · 1 item

UsesD-(-)-Lactic acid is a useful biochemical for proteomics research. It is also used in the production of chiral drug and in the chemical synthesis. Lactic acid is used as a reagent in organic synthesis (in the manufacture of adhesives). It is used in the leather, textile, and tanning industries. It may be used as a plasticizer, a catalyst, or an acidifying agent. Lactic acid has even been used as a flavoring agent in the manufacture of tobacco products.

Upstream & downstream products

Upstream raw materials

D-Glyceraldehyde Methylglyoxal

Downstream products

Ferrous lactate Ethyl pyruvate Pyruvic acid SODIUM STEAROYL LACTYLATE

Suppliers100 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

郑州阿尔法化工有限公司+86-18530059196 · [email protected]

衢州润东化工有限公司0570-8789886 18892685668 · [email protected]

Shandong chuangyingchemical Co., Ltd.18853181302 · [email protected]

Additional notes · 1 item

DefinitionChEBI: (R)-lactic acid is an optically active form of lactic acid having (R)-configuration. It has a role as an Escherichia coli metabolite and a human metabolite. It is a conjugate acid of a (R)-lactate. It is an enantiomer of a (S)-lactic acid.