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Ammonium permanganate

HCID 61604
NotesReactions
Basic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
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Basic information

CAS
13446-10-1
Standard SMILES
[NH4+].[O]=[Mn](=[O])(=[O])[O-]
InChIKey
PASCZIGWJWZUOV-UHFFFAOYSA-O
Molecular formula
H3N.HMnO4
Average molar mass
136.974 g/mol
Monoisotopic mass
136.952076

Overview

Ammonium permanganate appears as a crystal or powder with a rich violet-brown or dark purple metallic sheen. Toxic by ingestion or inhalation of dust.

Names & identifiers

Preferred name
Ammonium permanganate
IUPAC
azanium permanganate

Names & synonyms

Ammonium permanganate13446-10-1Permanganic acid, ammonium saltPermanganic acid (HMnO4), ammonium saltammonium manganesoylolateAmmonium permanganic acidRefChem:112195azanium;permanganateAmmonium permanganate [Forbidden]SCHEMBL524273DTXSID101028187DB-253791
Show more names
Q1587180

Database identifiers

CAS
13446-10-1
PubChem CID
61604
DTXSID
DTXSID101028187

Properties

Computed structural properties

Topological polar surface area
75.3 Ų
Hydrogen bond donors
1
Hydrogen bond acceptors
4
Rotatable bonds
0
Heavy atoms
6
Formal charge
0
Complexity
95.8

Experimental & physicochemical properties

Chemical ClassesReactive agents - 3rd degree
Density2.208 @25 °C
Physical DescriptionAmmonium permanganate appears as a crystal or powder with a rich violet-brown or dark purple metallic sheen. Toxic by ingestion or inhalation of dust.

Safety & regulation

Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.

Hazard information

Regulatory InformationThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)
DOT LabelOxidizer Corrosive
Fire HazardsExcerpt from ERG Guide 140 [Oxidizers]:
Health HazardsExcerpt from ERG Guide 140 [Oxidizers]:
Reactive GroupSalts, Acidic
Reactivity AlertsExplosive
Reactivity Profile · 1 item

Dry AMMONIUM PERMANGANATE may explode on shock, friction or heating [Hawley]. Mixtures with acetic acid or acetic anhydride may explode if not kept cold [Von Schwartz p 34 1918]. Explosions can occur when permanganates that have been treated with sulfuric acid come in contact with benzene, carbon disulfide, diethyl ether, ethyl alcohol, petroleum, or organic matter.

DOT Hazard Classification · 2 items

Ammonium permanganate

Forbidden explosives/materials (49 eCFR § 173.54/§ 173.21)

Air and Water ReactionsSoluble in water
Hazard Classes and CategoriesReactive agents - 3rd degree

Safety & protection

Chemistry & industry

Pharmacology

Metabolism/Metabolites · 1 item

Manganese is absorbed mainly via ingestion, but can also be inhaled. It binds to alpha-2-macroglobulin, albumin, or transferrin in the plasma and is distributed to the brain and all other mammalian tissues, though it tends to accumulate more in the liver, pancreas, and kidney. Manganese is capable of existing in a number of oxidation states and is believed to undergo changes in oxidation state within the body. Manganese oxidation state can influence tissue toxicokinetic behavior, and possibly toxicity. Manganese is excreted primarily in the faeces. (L228)

Related reactions

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Compound notes

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On this pageBasic informationOverviewNames & identifiersPropertiesSafety & regulationChemistry & industryRelated reactionsCompound notes
Fire Fighting
Excerpt from ERG Guide 140 [Oxidizers]:
First AidExcerpt from ERG Guide 140 [Oxidizers]:
Nonfire Spill ResponseExcerpt from ERG Guide 140 [Oxidizers]:
Isolation and EvacuationExcerpt from ERG Guide 140 [Oxidizers]:
Minimum Risk LevelChronic Inhalation: 0.0003 mg/m3 (L134)
Protective Action Criteria (PAC) · 3 items

0.12 [mg/m3]

1.3 [mg/m3]

63 [mg/m3]

Personal Protective Equipment (PPE)Excerpt from ERG Guide 140 [Oxidizers]:

Toxicology

Treatment · 1 item

EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.

Health Effects · 1 item

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

Exposure RoutesOral (L228) ; inhalation (L228)
Toxicity Summary · 1 item

Manganese is a cellular toxicant that can impair transport systems, enzyme activities, and receptor functions. It primarily targets the central nervous system, particularily the globus pallidus of the basal ganglia. It is believed that the manganese ion, Mn(II), enhances the autoxidation or turnover of various intracellular catecholamines, leading to increased production of free radicals, reactive oxygen species, and other cytotoxic metabolites, along with a depletion of cellular antioxidant defense mechanisms, leading to oxidative damage and selective destruction of dopaminergic neurons. In addition to dopamine, manganese is thought to perturbations other neurotransmitters, such as GABA and glutamate. In order to produce oxidative damage, manganese must first overwhelm the antioxidant enzyme manganese superoxide dismutase. The neurotoxicity of Mn(II) has also been linked to its ability to substitute for Ca(II) under physiological conditions. It can enter mitochondria via the calcium uniporter and inhibit mitochondrial oxidative phosphorylation. It may also inhibit the efflux of Ca(II), which can result in a loss of mitochondrial membrane integrity. Mn(II) has been shown to inhibit mitochondrial aconitase activity to a significant level, altering amino acid metabolism and cellular iron homeostasis. (L228)

Signs and Symptoms · 1 item

Manganese mainly affects the nervous system and may cause behavioral changes and other nervous system effects, which include movements that may become slow and clumsy. This combination of symptoms when sufficiently severe is referred to as “manganism”. (L228)

Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).