2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline
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Basic information
- CAS
60547-97-9- Standard SMILES
COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC- InChIKey
APKHJGDGWQDBGM-UHFFFAOYSA-N- Molecular formula
- C14H19N5O2
- Average molar mass
- 289.33 g/mol
- Monoisotopic mass
- 289.15387485
Overview
prazosin metabolite; RN given refers to parent cpd
Names & identifiers
- Preferred name
- 2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline
- IUPAC
- 6,7-dimethoxy-2-piperazin-1-ylquinazolin-4-amine
- English name
- 2-Piperazine-4-amino-6,7-dimethoxyquinazoline
- Molecular formula
- C14H19N5O2
- Molecular weight
- 289.33
Names & synonyms
60547-97-92-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline2-Padqz4-Quinazolinamine, 6,7-dimethoxy-2-(1-piperazinyl)-1X8JI3451K1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)piperazineDTXSID00209293RefChem:424742DTXCID201317842-piperazine-4-amino-6, 7-dimethoxyquinazoline6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine2-piperazine-4-amino-6,7-dimethoxyquinazoline
Show more names
Terazosin-004Terazosin EP IMP CTerazosin Impurity7Prazosin EP Impurity CTerazosin EP IMpurity CDoxazosin EP Impurity GDoxazocin ep impurity G7-diMethoxyquinazoline HCl2-(1-Piperazinyl)-4-aMino-6
2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline6,7-dimethoxy-2-piperazin-1-ylquinazolin-4-amineMFCD00563872DOXAZOSIN IMPURITY G6,7-Dimethoxy-2-(1-piperazinyl)-4-quinazolinamineCHEMBL12264-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline4-amino-2-(1-piperazinyl)-6,7-dimethoxyquinazoline
Properties
Computed structural propertiesFilling in
- XLogP
- 1
- Topological polar surface area
- 85.5 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 3
- Heavy atoms
- 21
- Formal charge
- 0
- Complexity
- 339
Physicochemical properties
- Melting point
- 219 · 219-221°C (dec.)
- Boiling point
- 527 · 527.0±60.0 °C(Predicted)
- Density
- 1.265 · 1.265±0.06 g/cm3(Predicted)
- storage temp.
- 2 · Sealed in dry,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- powder
- pka
- 8.55 · 8.55±0.10(Predicted)
- color
- White
- CAS DataBase Reference
- 60547 · 60547-97-9(CAS DataBase Reference)
- FDA UNII
- 1 X8JI3451K · 1X8JI3451K
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
- Hazard Codes
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Hazard Classes and CategoriesAcute Tox. 4 (97.6%)
Safety data
- hs_code
- 2933599590
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501
Chemistry & industry
Applications
Uses2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline (Terazosin EP Impurity C) is a metabolite of Prazosin. It is also an impurity arising in the synthesis of Terazosin (T105000).
Related reactions
123 records
Compound notes
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