2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline

HCID 616267CAS 60547-97-9
Substructure searchFind similar structures

Basic information

Standard SMILES
COc1cc2nc(N3CCNCC3)nc(N)c2cc1OC
InChIKey
APKHJGDGWQDBGM-UHFFFAOYSA-N
Molecular formula
C14H19N5O2
Average molar mass
289.33 g/mol
Monoisotopic mass
289.15387485

Overview

prazosin metabolite; RN given refers to parent cpd

Names & identifiers

Preferred name
2-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline
IUPAC
6,7-dimethoxy-2-piperazin-1-ylquinazolin-4-amine
English name
2-Piperazine-4-amino-6,7-dimethoxyquinazoline
Molecular formula
C14H19N5O2
Molecular weight
289.33

Names & synonyms

60547-97-92-(1-Piperazinyl)-4-amino-6,7-dimethoxyquinazoline2-Padqz4-Quinazolinamine, 6,7-dimethoxy-2-(1-piperazinyl)-1X8JI3451K1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)piperazineDTXSID00209293RefChem:424742DTXCID201317842-piperazine-4-amino-6, 7-dimethoxyquinazoline6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine2-piperazine-4-amino-6,7-dimethoxyquinazoline
Show more names
Terazosin-004Terazosin EP IMP CTerazosin Impurity7Prazosin EP Impurity CTerazosin EP IMpurity CDoxazosin EP Impurity GDoxazocin ep impurity G7-diMethoxyquinazoline HCl2-(1-Piperazinyl)-4-aMino-6
2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline6,7-dimethoxy-2-piperazin-1-ylquinazolin-4-amineMFCD00563872DOXAZOSIN IMPURITY G6,7-Dimethoxy-2-(1-piperazinyl)-4-quinazolinamineCHEMBL12264-amino-6,7-dimethoxy-2-(1-piperazinyl)quinazoline4-amino-2-(1-piperazinyl)-6,7-dimethoxyquinazoline

Database identifiers

CAS
60547-97-9
PubChem CID
616267
DTXSID
DTXSID00209293
ChEMBL
CHEMBL1226
UNII
1X8JI3451K
EC Number
611-989-9
Nikkaji
J420.652E

Properties

Computed structural properties

XLogP
1
Topological polar surface area
85.5 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
7
Rotatable bonds
3
Heavy atoms
21

Physicochemical properties

Melting point
219 · 219-221°C (dec.)
Boiling point
527 · 527.0±60.0 °C(Predicted)
Density
1.265 · 1.265±0.06 g/cm3(Predicted)
storage temp.
2 · Sealed in dry,2-8°C
solubility
DMSO (Slightly), Methanol (Slightly)
form
powder

Safety & regulation

GHS classification

GHS Classification · 4 items

Warning

H302 (97.6%): Harmful if swallowed [Warning Acute toxicity, oral]

P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 41 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesAcute Tox. 4 (97.6%)

Safety data

hs_code
2933599590
Signal word
Warning
Symbol(GHS)
GHS07
hazard_code
Xi
Hazard statements
H302-H315-H319-H335
Precautionary statements
P261-P264-P270-P271-P280-P301+P312+P330-P302+P352-P304+P340+P312-P305+P351+P338-P332+P313-P337+P313-P362-P403+P233-P405-P501

Chemistry & industry

Applications

Uses2-Piperazinyl-4-amino-6,7-dimethoxyquinazoline (Terazosin EP Impurity C) is a metabolite of Prazosin. It is also an impurity arising in the synthesis of Terazosin (T105000).

Suppliers50 total

上海策嵘生物科技有限公司[email protected]
济南百隆化学有限公司[email protected] · [email protected]
艾吉析科技（上海）有限公司17717235263 · [email protected]
怀化元研达生物技术有限责任公司18711085600 · [email protected]
合肥翰刚医药科技有限公司+8618062405514 · [email protected]

Related reactions

123 records
New reaction record

Linked notes

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