Basic information
- Standard SMILES
[Na+].[Na+].[Na+].[O]=[V]([O-])([O-])[O-]- InChIKey
IHIXIJGXTJIKRB-UHFFFAOYSA-N- Molecular formula
- Na3-V-O4
- Average molar mass
- 183.908 g/mol
- Monoisotopic mass
- 183.89292582
Overview
Trisodium vanadate is an inorganic sodium salt of formula Na3VO4 containing the tetrahedral VO43. It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent, a radiation protective agent and an apoptosis inducer. It contains a vanadate(3-).
Names & identifiers
- Preferred name
- Sodium orthovanadate
- IUPAC
- trisodium;trioxido(oxo)vanadium
Names & synonyms
Sodium orthovanadate13721-39-6Trisodium vanadateSodium o-vanadateSodium pervanadateSodium vanadium oxide (Na3VO4)Sodium tetraoxovanadate(3-)Sodium vanadate (ortho)Trisodium tetraoxovanadateVanadic acid, trisodium saltTRISODIUM ORTHOVANADATEtrisodium;trioxido(oxo)vanadium
Show more names
Vanadic acid (H3VO4), sodium saltSodium vanadate(V) (Na3VO4)MFCD00003511DTXSID20372697845MV6C8VVanadic (II) Acid, Trisodium SaltCCRIS 9063EINECS 237-287-9
Database identifiers
- CAS
13721-39-6- PubChem CID
- 61671
- DTXSID
DTXSID2037269- ChEBI
CHEBI:35607- UNII
- 7845MV6C8V
- EC Number
- 237-287-9
Properties
Computed structural properties
- Topological polar surface area
- 86.3 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 36.8
Experimental & physicochemical properties
Chemical ClassesMetals -> Metals, Inorganic Compounds
Physical DescriptionWhite odorless granules; [Alfa Aesar MSDS]
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 1.7% (1 of 59) of reports.
Warning
H302 (98.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 59 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Vanadate (VO43-), trisodium, (T-4)-
Trisodium orthovanadate: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryCauses convulsions in subcutaneous lethal-dose studies; [RTECS] A skin and strong eye irritant; Harmful by ingestion and inhalation; Reproductive effects observed in experimental animals; [Alfa Aesar MSDS] See Sodium metavanadate.
Hazard Classes and CategoriesAcute Tox. 4 (98.3%)
Safety & protection
Minimum Risk LevelAcute Inhalation: 0.0002 mg/m3 (L134)
Intermediate Oral: 0.003 mg/kg/day (L134)
Protective Action Criteria (PAC)
0.092 [mg/m3]
1.0 [mg/m3]
65 [mg/m3]
Toxicology
Treatment
EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration.
Health EffectsBreathing high levels of vanadium affects the lungs, throat, and eyes. Ingestion of vanadium may cause kidney and liver damage, birth defects, or death. (L837)
Exposure RoutesOral (L837) ; inhalation (L837) ; dermal (L837)
Toxicity Summary
Vanadium damages alveolar macrophages by decreasing the macrophage membrane integrity, thus impairing the cells' phagocytotic ability and viability. The pentavalent form of vanadium, vanadate, is a potent inhibitor of the Ca+-ATPase and Na+,K+-ATPase of plasma membranes, which decreases intracellular ATP concentration. Vanadium is also believed to induce the production of reactive oxygen species. This may damage DNA and also cause oxidative stress, which can damage the reproductive system. Vanadium also inhibits protein tyrosine phosphatases, producing insulin-like effects. (L837, A247, A248, A249, A250, A251)
Signs and SymptomsInhalation of vanadium causes lung irritation, coughing, wheezing, chest pain, runny nose, and a sore throat. (L837)
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Vanadium is absorbed mainly via inhalation, though small amounts can be absorbed through the skin and gastrointestional tract. It is rapidly distributed in the plasma, mainly to the kidney, liver, lungs, heart, bone, where it tends to accumulate. With the help of cytochrome P-450 enzymes, it can interconvert between its two oxidation states, vanadyl (V+4) and vanadate (V+5). Both states of vanadium can reversibly bind to transferrin protein in the blood and then be taken up into erythrocytes. Vanadium is excreted mainly in the urine. (L837)
Uses & manufacturing
Uses
Sodium orthovanadate is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. (L854)
General Manufacturing InformationSodium vanadium oxide (Na3VO4): ACTIVE
Related reactions
10 records
Linked notes
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