Sodium orthovanadate
Basic information
- CAS
13721-39-6- Standard SMILES
[Na+].[Na+].[Na+].[O]=[V]([O-])([O-])[O-]- InChIKey
IHIXIJGXTJIKRB-UHFFFAOYSA-N- Molecular formula
- Na3-V-O4
- Average molar mass
- 183.908 g/mol
- Monoisotopic mass
- 183.89292582
Overview
Trisodium vanadate is an inorganic sodium salt of formula Na3VO4 containing the tetrahedral VO43. It has a role as an EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor, an antineoplastic agent, a radiation protective agent and an apoptosis inducer. It contains a vanadate(3-).
Names & identifiers
- Preferred name
- Sodium orthovanadate
- IUPAC
- trisodium;trioxido(oxo)vanadium
- English name
- Sodium orthovanadate
- Molecular formula
- Na3VO4
- Molecular weight
- 183.91
Names & synonyms
Sodium orthovanadate13721-39-6Trisodium vanadateSodium o-vanadateSodium pervanadateSodium vanadium oxide (Na3VO4)Sodium tetraoxovanadate(3-)Sodium vanadate (ortho)Trisodium tetraoxovanadateVanadic acid, trisodium saltTRISODIUM ORTHOVANADATEtrisodium;trioxido(oxo)vanadium
Show more names
SODIUM VANADATESodium orthavanadiumSodium Orthovanadate(Ⅴ)sodiumvanadate(v)(na3vo4)DECAVANDATEtrisodiumvanadateIs sodium vanadatePervanadate(100mM)
Vanadic acid (H3VO4), sodium saltSodium vanadate(V) (Na3VO4)MFCD00003511DTXSID20372697845MV6C8VVanadic (II) Acid, Trisodium SaltCCRIS 9063EINECS 237-287-9
Database identifiers
- CAS
13721-39-6
Properties
Computed structural properties
- Topological polar surface area
- 86.3 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 0
- Heavy atoms
- 8
- Formal charge
- 0
- Complexity
- 36.8
Experimental & physicochemical properties
Chemical ClassesMetals -> Metals, Inorganic Compounds
Physical DescriptionWhite odorless granules; [Alfa Aesar MSDS]
Physicochemical properties
- Melting point
- 850 · 850-866 °C(lit.)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- 2 O: · H2O: soluble
- form
- Solid
- color
- off-white
- biological source
- synthetic (organic)
- Water Solubility
- soluble
- Exposure limits
- 0.05 mg/m3 · NIOSH: Ceiling 0.05 mg/m3
- Stability
- Stable. Incompatible with strong oxidizing agents.
- InChI
- InChI=1S/3Na.4O.V
- InChIKey
- HQHUIUQMQXUPHI-UHFFFAOYSA-N
- SMILES
- [V](=O)(O[Na])(O[Na])O[Na]
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 1.7% (1 of 59) of reports.
Warning
H302 (98.3%): Harmful if swallowed [Warning Acute toxicity, oral]
P261, P264, P270, P271, P280, P301+P317, P302+P352, P304+P340, P317, P321, P330, P362+P364, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 59 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Vanadate (VO43-), trisodium, (T-4)-
Trisodium orthovanadate: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryCauses convulsions in subcutaneous lethal-dose studies; [RTECS] A skin and strong eye irritant; Harmful by ingestion and inhalation; Reproductive effects observed in experimental animals; [Alfa Aesar MSDS] See Sodium metavanadate.
Hazard Classes and CategoriesAcute Tox. 4 (98.3%)
Safety & protection
Minimum Risk LevelAcute Inhalation: 0.0002 mg/m3 (L134)
Intermediate Oral: 0.003 mg/kg/day (L134)
Protective Action Criteria (PAC)
0.092 [mg/m3]
1.0 [mg/m3]
65 [mg/m3]
Toxicology
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Vanadium is absorbed mainly via inhalation, though small amounts can be absorbed through the skin and gastrointestional tract. It is rapidly distributed in the plasma, mainly to the kidney, liver, lungs, heart, bone, where it tends to accumulate. With the help of cytochrome P-450 enzymes, it can interconvert between its two oxidation states, vanadyl (V+4) and vanadate (V+5). Both states of vanadium can reversibly bind to transferrin protein in the blood and then be taken up into erythrocytes. Vanadium is excreted mainly in the urine. (L837)
Uses & manufacturing
Uses
Sodium orthovanadate is often added to buffer solutions that are used in protein analysis in molecular biology. The aim is to preserve the phosphorylation of proteins of interest by inhibiting endogenous phosphatases present in cell lysate mixture. (L854)
General Manufacturing InformationSodium vanadium oxide (Na3VO4): ACTIVE
Applications
UsesSodium orthovanadate (Na3VO4) can be used as a metal precursor in the synthesis of:Vanadium-MCM-48 (V-MCM-48) by anion-exchange method. V-MCM-48 is used as a catalyst in oxidation of styrene to benzaldehyde.Nanorods of vanadium oxide particles by glycothermal method.Yttrium vanadate (YVO4) doped with colloidal europium.
UsesSodium Orthovanadate is an inhibitor of several phosphatases and kinases. General inhibitor of tyrosine phosphatases, a large family of enzymes that catalyze the removal of phosphate groups from tyrosine residues.
Preparation methods
PreparationSodium orthovanadate is produced by dissolving vanadium(V) oxide in a solution of sodium hydroxide: V2O5 + 6 NaOH → 2 Na3VO4 + 3 H2OThe salt features tetrahedral VO3-4 anion centers linked to octahedral Na+ cation sites.
Related reactions
10 records
Compound notes
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