DL-Serine

HCID 617CAS 302-84-1
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Basic information

Standard SMILES
NC(CO)C(=O)O
InChIKey
MTCFGRXMJLQNBG-UHFFFAOYSA-N
Molecular formula
C3H7NO3
Average molar mass
105.09 g/mol
Monoisotopic mass
105.04259309

Names & identifiers

Preferred name
DL-Serine
IUPAC
2-amino-3-hydroxypropanoic acid
English name
DL-Serine
Molecular formula
C3H7NO3
Molecular weight
105.09

Names & synonyms

DL-Serine302-84-1Serine, DL-00PAR1C66FNSC-9960DTXSID70859325NSC99602-azaniumyl-3-hydroxypropanoateSerine DL-RefChem:1083916DTXCID20202802206-130-6
Show more names
SERINEserinDL-SER2-AMINO-3-HYDROXY-PROPIONIC ACIDDL-SerinDL-Ser-OHDL-SERINE,FCC
2-Amino-3-hydroxypropanoic acidSerine DL-formH-DL-Ser-OHSERINE, (L)d,l-serineL-Serine-2-13c-15N2-amino-3-hydroxy-propanoic acidDL-2-Amino-3-hydroxypropionic Acid

Database identifiers

CAS
302-84-1、312-84-5、56-45-1
PubChem CID
617
DTXSID
DTXSID70859325
ChEBI
CHEBI:17822
UNII
00PAR1C66F
EC Number
206-130-6
Nikkaji
J1.277G

Properties

Computed structural properties

XLogP
-3.1
Topological polar surface area
83.6 Ų
Hydrogen bond donors
3
Hydrogen bond acceptors
4
Rotatable bonds
2
Heavy atoms
7

Experimental & physicochemical properties

Physical DescriptionSolid; [Merck Index] Beige crystalline solid; [Sigma-Aldrich MSDS]

Physicochemical properties

Melting point
240 °C · 240 °C (dec.) (lit.)
Boiling point
197.09 °C · 197.09°C (rough estimate)
Density
1.53 · 1.53
refractive index
1.4368 · 1.4368 (estimate)
FLAVIS Number
17.02 · 17.020 | D,L-Serine
storage temp.
30 °C · Store below +30°C.

Safety & regulation

GHS classification

GHS Classification · 3 items

This chemical does not meet GHS hazard criteria for 99.6% (261 of 262) of all reports.

Not Classified；Reported as not meeting GHS hazard criteria by 261 of 262 companies (only 0.4% companies provided GHS information). For more detailed information, please visit ECHA C&L website.

Aggregated GHS information provided per 262 reports by companies from 2 notifications to the ECHA C&L Inventory.；Reported as not meeting GHS hazard criteria per 261 of 262 reports by companies.；There is 1 notification provided by 1 of 262 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 4 items

Chemical: DL-Serine

Regulation (EC) No 1831/2003 (amended)

Status: Active Update: 12-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21820

Serine: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - DL-Serine: Environment tier I assessment；Evaluation - Chemicals that are unlikely to require further regulation to manage risks to human health
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS] See L-Serine.
Hazard Classes and CategoriesNot Classified

Regulatory information

Regulatory Information · 4 items

Chemical: DL-Serine

Regulation (EC) No 1831/2003 (amended)

Status: Active Update: 12-08-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21820

Serine: Does not have an individual approval but may be used under an appropriate group standard

Safety data

PPE
Eyeshields, Gloves, type N95 (US)
wgk
3
tsca
TSCA listed
rtecs
VT8100000
hs_code
29225000
risk_code
36/37/38

Chemistry & industry

Uses & manufacturing

UsesA non-essential amino acid; [Merck Index]
General Manufacturing InformationSerine: ACTIVE
Applications · 2 items

DescriptionDL-Serine is a kind of neutral aliphatic amino acids containing hydroxyl groups with polarity but being uncharged, and belongs to nonessential amino acids for human body. It has a high content in sericin silk protein and fibroin protein. It can be formed from the methyl transfer reaction of glycine. It can also be converted to pyruvate or hydroxy pyruvate through deamination. It is also an important raw material for in vivo synthesis of choline and cysteine.

UsesDL-Serine is used in the synthesis of novel tryptoline derivatives as IDO (indoleamine 2,3-Deoxygenase) inhibitors, for potential use in Alzheimer’s treatment.

Preparation methods

PreparationDL-serine is obtained by complexing glycine under the catalysis of copper ions and then combining with formaldehyde under alkaline conditions, followed by acidification, ion exchange, and crystallization in ethanol.

Upstream & downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
普洛药业股份有限公司/浙江横店普洛进出口有限公司+86-0571-87635730 +86-13588737631
Additional notes · 1 item

DefinitionChEBI: Serine is an alpha-amino acid that is alanine substituted at position 3 by a hydroxy group. It has a role as a fundamental metabolite. It is an alpha-amino acid and a polar amino acid. It contains a hydroxymethyl group. It is a conjugate base of a serinium. It is a conjugate acid of a serinate. It is a tautomer of a serine zwitterion.

Related reactions

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Linked notes

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