Basic information
- CAS
13966-29-5- Standard SMILES
[234U]- InChIKey
JFALSRSLKYAFGM-AHCXROLUSA-N- Molecular formula
- U
- Average molar mass
- 234.041 g/mol
- Monoisotopic mass
- 234.04095
Overview
Uranium-234 is an isotope of uranium. Uranium is a chemical element that has the symbol U and atomic number 92. It is a normal part of rocks, soil, air, and water, and occurs in nature in the form of minerals. Natural uranium is a mixture of three radioactive isotopes called uranium-234, uranium-235, and uranium-238. Uranium is also used as a colorant in uranium glass, producing orange-red to lemon yellow hues. (L248, L249)
Names & identifiers
- Preferred name
- Uranium-234
- IUPAC
- uranium-234
- English name
- URANIUM-234
- Molecular formula
- U
- Molecular weight
- 233.99291
Names & synonyms
Uranium-234Uranium, isotope of mass 23413966-29-5DTXSID40891752234U radioisotopeUranium 234(234U)uraniumU-234 radioisotopeRefChem:193206DTXCID601030941234U isotopeIsotope:234U
Show more names
234U (isotope)Uranium-234 isotopeIsotope:Uranium-234(~234~U)UraniumSCHEMBL29420461Q2153640
Database identifiers
- CAS
13966-29-5- PubChem CID
- 61704
- DTXSID
DTXSID40891752
Properties
Computed structural properties
- Topological polar surface area
- 0 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 0
- Rotatable bonds
- 0
- Heavy atoms
- 1
- Formal charge
- 0
- Complexity
- 0
Physicochemical properties
- EPA Substance Registry System
- -234 · Uranium-234 (13966-29-5)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety & protection
Minimum Risk Level
Intermediate Inhalation: 0.0004 mg/m3 (Soluble uranium salts) (L134) Chronic Inhalation: 0.0003 mg/m3 (Soluble uranium salts) (L134) Intermediate Oral: 0.002 mg/kg/day (Soluble uranium salts) (L134) Intermediate Inhalation: 0.008 mg/m3 (Insoluble uranium compounds) (L134)
Toxicology
Treatment
Treatment reversing the effects of irradiation is currently not possible. Anaesthetics and antiemetics are administered to counter the symptoms of exposure, as well as antibiotics for countering secondary infections due to the resulting immune system deficiency. (L1852)
Health Effects
Uranium primarily damages the kidney, but may also damage the lungs, central nervous system, and immune system. Uranium's radioactivity is believed to damage the DNA, resulting in carcinogenic effects and reproductive and developmental damage. (L248, L249)
Exposure RoutesOral (L249) ; inhalation (L249) ; dermal (L249) ; radiation (L249)
Toxicity Summary
Uranium is combined with either bicarbonate or a plasma protein in the blood but once in the kidney, it is released and forms complexes with phosphate ligands and proteins in the tubular wall, causing damage. Uranium may also inhibit both sodium transport-dependent and independent ATP utilization and mitochondrial oxidative phosphorylation in the renal proximal tubule. Uranium causes respiratory diseases by damaging alveolar epithelium type II cells in the lungs. Uranium induces c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK) activation, which in turn induces tumor necrosis factor alpha (TNF-alpha) secretion and generates and inflammatory response in the lungs. Studies have shown that the more soluble the uranium salt, the more toxic it is. Ionizing radiation produced by uranium damages the DNA, resulting in gene mutations and chromosomal aberrations. This can both both initiate and promote carcinogenesis, and interfere with reproduction and development. (L249, A160)
Chemistry & industry
Pharmacology
Metabolism/Metabolites
Uranium is absorbed in low amounts via oral, inhalation, and dermal routes. Uranium in body fluids generally exists as the uranyl ion (UO2)2+ complexed with anions, such as citrate and bicarbonate, or plasma proteins. Uranium preferentially distributes to bone, liver, and kidney. The large majority of uranium that enters the body is not absorbed and is eliminated from the body via the urine and faeces. (L248)
Uses & manufacturing
UsesUranium is also used as a colorant in uranium glass, producing orange-red to lemon yellow hues. (L248, L249)
Additional notes
DefinitionA natural isotope of uranium with half-life of 2.48 × 105 years; it is separated by extraction with trioctylphosphine oxide. Used in nuclear research, with potential use in fission detectors for counting fast neutrons.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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