Basic information
- CAS
30390-50-2- Standard SMILES
CCCCCC=CCCC=O- InChIKey
CWRKZMLUDFBPAO-UHFFFAOYSA-N- Molecular formula
- C10H18O
- Average molar mass
- 154.25 g/mol
- Monoisotopic mass
- 154.13576519
Overview
4-Decenal has been reported in Porophyllum ruderale with data available.
Names & identifiers
- Preferred name
- 4-Decenal
- IUPAC
- dec-4-enal
- English name
- DECENAL
- Molecular formula
- C10H18O
- Molecular weight
- 154.25
Names & synonyms
4-Decenal30390-50-2DTXSID0067555RefChem:1070565DTXCID8038190641-403-74-decen-1-al(E)-4-decen-1-alSCHEMBL1626855SCHEMBL7296514AKOS028109351DB-045659
Show more names
4-Decene-1-al
DB-054810
Database identifiers
- CAS
30390-50-2- PubChem CID
- 61875
- DTXSID
DTXSID0067555- EC Number
- 641-403-7
Properties
Computed structural properties
- XLogP
- 3.1
- Topological polar surface area
- 17.1 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 1
- Rotatable bonds
- 7
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 105
Experimental & physicochemical properties
Food AdditivesFLAVORING AGENT OR ADJUVANT -> FDA Substance added to food
Density0.843-0.850
Flavoring AgentsEU Flavoring substances
Solubility
soluble in alcohol and most fixed oils; insoluble in water
(in ethanol)
Boiling Point78-80 °C (10 mm Hg)
Refractive Index1.442-1.447
Physical Descriptioncolourless to slightly yellow liquid with an orange-like, fatty odour
Physicochemical properties
- Melting point
- -16 °C · -16°C (estimate)
- Boiling point
- 200 ℃ · 200℃
- Density
- 0.835 · 0.835
- FLAVIS Number
- 5.096 · 05.096 | 4-Decenal
- refractive index
- 1.445 · 1.4450
- FEMA
- 3264 · 3264 | 4-DECENAL
- Flash point
- 81 ℃ · 81℃
- Odor
- 1 % · at 1.00 % in propylene glycol. aldehydic fatty citrus orange
- Odor Type
- citrus
- JECFA Number
- 326 · 326
- Cosmetics Ingredients Functions
- PERFUMINGFRAGRANCE
- LogP
- 3.77 · 3.77
- Substances Added to Food (formerly EAFUS)
- 4 · 4-DECENAL
- EPA Substance Registry System
- 4 · 4-Decenal (30390-50-2)
- TSCA
- TSCA listed
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 100% (138 of 138) of all reports.
Not Classified
Aggregated GHS information provided per 138 reports by companies from 1 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: 4-Decenal
4-Decenal: Does not have an individual approval but may be used under an appropriate group standard
Other Safety InformationIMAP assessments - 4-Decenal: Human health tier I assessment
Hazard Classes and CategoriesNot Classified
Toxicology
TreatmentKidney dialysis is usually needed to relieve the symptoms of uremic syndrome until normal kidney function can be restored.
Health EffectsChronic exposure to uremic toxins can lead to a number of conditions including renal damage, chronic kidney disease and cardiovascular disease.
Exposure RoutesEndogenous, Ingestion, Dermal (contact)
Toxicity Summary
Uremic toxins such as 4-Decenal are actively transported into the kidneys via organic ion transporters (especially OAT3). Increased levels of uremic toxins can stimulate the production of reactive oxygen species. This seems to be mediated by the direct binding or inhibition by uremic toxins of the enzyme NADPH oxidase (especially NOX4 which is abundant in the kidneys and heart) (A7868). Reactive oxygen species can induce several different DNA methyltransferases (DNMTs) which are involved in the silencing of a protein known as KLOTHO. KLOTHO has been identified as having important roles in anti-aging, mineral metabolism, and vitamin D metabolism. A number of studies have indicated that KLOTHO mRNA and protein levels are reduced during acute or chronic kidney diseases in response to high local levels of reactive oxygen species (A7869).
Signs and Symptoms
As a uremic toxin, this compound can cause uremic syndrome. Uremic syndrome may affect any part of the body and can cause nausea, vomiting, loss of appetite, and weight loss. It can also cause changes in mental status, such as confusion, reduced awareness, agitation, psychosis, seizures, and coma. Abnormal bleeding, such as bleeding spontaneously or profusely from a very minor injury can also occur. Heart problems, such as an irregular heartbeat, inflammation in the sac that surrounds the heart (pericarditis), and increased pressure on the heart can be seen in patients with uremic syndrome. Shortness of breath from fluid buildup in the space between the lungs and the chest wall (pleural effusion) can also be present.
Carcinogen ClassificationNo indication of carcinogenicity to humans (not listed by IARC).
Safety data
- tsca
- TSCA listed
Chemistry & industry
Pharmacology
Metabolism/MetabolitesUremic toxins tend to accumulate in the blood either through dietary excess or through poor filtration by the kidneys. Most uremic toxins are metabolic waste products and are normally excreted in the urine or feces.
Uses & manufacturing
UsesNaturally produced by the body (endogenous).
Use Classification
Flavouring Agent -> FLAVOURING_AGENT -> JECFA Functional Classes
Flavoring Agents -> JECFA Flavorings Index
General Manufacturing Information4-Decenal: ACTIVE
Applications
OccurrenceReported formed in the auto-oxidation of lipids, grilled beef and soybeans
Preparation methods
PreparationFrom 1-octen-3-ol and vinyl ethyl ether in the presence of p-methylbenzene sulfonic acid.
Suppliers8 total
Hebei Zhuanglai Chemical Trading Co Ltd+86-16264648883 · [email protected]
北京安司莫森技术有限公司010-82954736 13391601435 · [email protected]
北京东华力拓科技发展有限公司010-88425576 · [email protected]
上海钰康生物科技有限公司+86-18930848214 +86-021-56762820 · [email protected]
厦门志信化学有限公司+86-5922680277 +86-13806087780 · [email protected]
深圳市丽晶生化科技有限公司0755-85201366 18938635012 · [email protected]
Mainchem Co., Ltd.+86-86-05926210733 · [email protected]
武汉青衫合源生物科技有限公司027-18327024450 18327024450 · [email protected]
Related reactions
1 records
Compound notes
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