Mefluidide-diolamine

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

LC50; Species: Anas platyrynchos (Mallard duck) oral 3750 mg/kg in the diet (one dose) >3750 mg/kg

LD50; Species: Apis mellifera (honey bee) acute contact >18.75 ug/bee

LD50; Species: Colinus virginianus (Bobwhite quail) oral >1500 mg/kg bw

EC50; Species: Skeletonema costatum (Diatom); Conditions: saltwater, static; Concentration: >767 ug/L for 5 days; Effect: population abundance /28.8% purity/

For more Ecotoxicity Values (Complete) data for Mefluidide-diolamine (16 total), please visit the HSDB record page.

IDENTIFICATION AND USE: Mefluidide-diolamine is a plant growth regulator and pesticide. HUMAN STUDIES: There are no data available. ANIMAL STUDIES: Mefluidide-diolamine was not dermally toxic when tested in rabbits at doses of 1000 mg/kg/day for 21 days. Effects were limited to slight erythema at the application site at the 1000 mg/kg/day dose. There were no treatment-related malformations or developmental variations when tested in rats. Clinical signs of neurotoxicity (such as tremors, ataxia, atonia, decreased limb tone, salivation) were seen in several studies (14-day oral in rabbit at or above 200 mg/kg/day, demyelination study in chickens at 1000 mg/kg/day and two developmental toxicity studies in rats at 115 mg/kg/day. Edema and swelling with myelin loss in sciatic nerve was observed in a dermal toxicity study in rabbits at doses of 720 mg/kg and above. However, these effects were not seen in an additional dermal test of similar duration using a 28.8% formulation of mefluidide-diolamine. Mefluidide-diolamine was assayed for induction of reverse mutations at the histidine locus of Salmonella typhimurium tester strains TA98, TA100, TA1535, TA1537 and TA1538 and it was negative with or without metabolic activation. ECOTOXICITY STUDIES: Mefluidide-diolamine was practically non-toxic to rainbow trout (Oncorhynchus mykiss), bluegill sunfish (Lepomis macrochirus), sheepshead minnow (Cyprinodon variegatus, waterflea (Daphnia magna, and to the estuarine marine mysid (Mysidopsis bahia). It was slightly toxic to the estuarine marine eastern oyster (Crassostrea virginica). It was practically nontoxic to honeybees on an acute contact basis. In plants symptoms of toxicity included stunting, chlorosis, necrosis and distortion.

/AQUATIC SPECIES/ Mefluidide-DEA is practically non-toxic to the estuarine marine mysid (Mysidopsis bahia), with a 96-hr EC50 >94.5 mg acid equivalent (ae)/L and a NOAEC of 31.5 mg ae/L. Mean measured concentrations were 15, 26, 42, 75 and 126 mg ai/L (11.25, 19.5, 31.5, 56.2 and 94.5 mg ae/L). One mortality to estuarine marine mysid occurred at the 52.2 mg ae/L treatment level and 2 mortalities occurred in the 94.5 mg ae/L treatment level. No other mortalities or sublethal effects occurred during the test.

/AQUATIC SPECIES/ Mefluidide-DEA is practically non-toxic to the cold water species, rainbow trout (Oncorhynchus mykiss), with a non-definitive 96-hour LC50 of >68.47 mg acid equivalent (ae)/L and a NOAEC of 68.47 mg ae/L (MRID 418937-02). No mortalities or sublethal signs of toxicity in rainbow trout were observed with test material in any of the tested concentrations. The mean measured concentrations were 15.2, 12.5, 24.4, 45.2, and 91.3 mg ai/L. (11.4, 9.3, 18.3, 33.9 and 68.4 mg ae/L).

/AQUATIC SPECIES/ Mefluidide-DEA is practically non-toxic to the warm water species, bluegill sunfish (Lepomis macrochirus) with a non-definitive 96-hour LC50 of >70.80 mg acid equivalent (ae)/L and a NOAEC of 70.80 mg ae/L. No mortalities or sublethal signs of toxicity in bluegill sunfish were observed with test material in any of the tested concentrations. The mean measured concentrations were 14.6, 19.7, 32.4, 58.3 and 94.4 mg ai/L(10.9, 14.7, 24.3, 43.7 and 70.8 mg ae/L).

/AQUATIC SPECIES/ Mefluidide-DEA is practically non-toxic to sheepshead minnow (Cyprinodon variegatus), with a non-definitive 96-hour LC50 of >84.75 mg acid equivalent (ae)/L and a NOAEC of 84.75 mg ae/L. No mortalities or sublethal signs of toxicity in sheephead minnow were observed with test material in any of the tested concentrations. The mean measured concentrations were 16, 28, 34, 68, and 113 mg ai/L (12, 21, 25.5, 51 and 84.7 mg ae/L).

For more Ecotoxicity Excerpts (Complete) data for Mefluidide-diolamine (9 total), please visit the HSDB record page.

/LABORATORY ANIMALS: Subchronic or Prechronic Exposure/ Mefluidide and its DEA salt were not dermally toxic when tested in rabbits at limit doses of 1000 mg/kg/day for 21 days. Effects were limited to slight erythema at the application site at the 1000 mg/kg/day dose.

/LABORATORY ANIMALS: Developmental or Reproductive Toxicity/ Groups of 25 mated female Sprague-Dawley rats were exposed on gestation days 6 through 15 to the diethanolamine salt of mefluidide (28.78% w/w, stated purity) at 0, 50, 200, or 400 mg/kg/day. The animals were sacrificed and cesarean sectioned on day 20. Maternal effects were lethality, clinical signs, and reduced body weight and food consumption at 400 mg/kg/day (maternal NOEL = 200 mg/kg/day). Increased resorptions were seen at 400 mg/kg/day (developmental NOEL = 200 mg/kg/day). There were no treatment-related malformations or developmental variations.

/LABORATORY ANIMALS: Neurotoxicity/ Clinical signs of neurotoxicity (such as tremors, ataxia, atonia, decreased limb tone, salivation) were seen in several studies (14-day oral in rabbit at or above 200 mg/kg/day, demyelination study in chickens at 1000 mg/kg/day and two developmental toxicity studies in rats at 115 mg/kg/day. Edema and swelling with myelin loss in sciatic nerve was observed in a dermal toxicity study in rabbits at doses of 720 mg/kg and above. However, these effects were not seen in an additional dermal test of similar duration using a 58.2% mefluidide formulation or diethanolamine salt of mefluidide 28.8%.

/GENOTOXICITY/ The diethanolamine salt of mefluidide (28.8% stated purity) was assayed for induction of reverse mutations at the histidine locus of Salmonella typhimurium tester strains TA98, TA100, TA1535, TA1537 and TA1538. Two trials per strain were conducted with or without S9 metabolic activation (ArchlorT-induced rat liver microsomes) in triplicate at 0 (deionized water), 100, 333, 667, 1000, 3330, and 5000 ug/plate (based on weight not actual content of a.i.). There was no treatment-related effect on revertants.

For more Non-Human Toxicity Excerpts (Complete) data for Mefluidide-diolamine (6 total), please visit the HSDB record page.

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W TKO /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's (LR) if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam (Valium) or lorazepam (Ativan) ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

0.57999999999999996

OPP

0.015

OPP

Diethanolamine Mefluidide

0.58

3900

Children

0.015

89

The Agency has completed its assessment of the dietary (water only), residential, occupational, and ecological risks associated with the use of pesticides containing the active ingredient mefluidide. Food risks are not assessed because there are no food/feed uses of mefluidide. Based on a review of the mefluidide database and public comments on the Agency's assessments for the active ingredient mefluidide, the Agency has sufficient information on the human health and ecological effects of mefluidide to make decisions as part of the reregistration process under FIFRA. The Agency has determined that currently registered uses of mefluidide will not pose unreasonable adverse effects to humans or the environment provided that the risk mitigation measures and label changes outlined in this RED are implemented; therefore, products containing mefluidide are eligible for reregistration if the risk mitigation measures outlined in the document are adopted and label amendments are made to implement these measures. ... Based on its evaluation of mefluidide, the Agency has determined that mefluidide products, unless labeled and used as specified in this document, could result in unreasonable adverse effects on the environment. Accordingly, should a registrant fail to implement any of the risk mitigation measures identified in this document, the Agency may take regulatory action to address the risk concerns from the use of mefluidide. If all changes outlined in this document are incorporated into the product labels, then current risks for mefluidide will be adequately mitigated for the purposes of this determination under FIFRA.

As the federal pesticide law FIFRA directs, EPA is conducting a comprehensive review of older pesticides to consider their health and environmental effects and make decisions about their continued use. Under this pesticide reregistration program, EPA examines newer health and safety data for pesticide active ingredients initially registered before November 1, 1984, and determines whether the use of the pesticide does not pose unreasonable risk in accordance to newer safety standards, such as those described in the Food Quality Protection Act of 1996. Pesticides for which EPA had not issued Registration Standards prior to the effective date of FIFRA '88 were divided into three lists based upon their potential for human exposure and other factors, with List B containing pesticides of greater concern than those on List C, and with List C containing pesticides of greater concern than those on List D. Diethanolamine mefluidide is found on List B. Case No: 2370; Pesticide type: herbicide; Case Status: OPP is reviewing data from the pesticide's producers regarding its human health and/or environmental effects, or OPP is determining the pesticide's eligibility for reregistration and developing the RED document.; Active ingredient (AI): diethanolamine mefluidide; Data Call-in (DCI) Date(s): 02/04/91; AI Status: The producers of the pesticide have made commitments to conduct the studies and pay the fees required for reregistration, and are meeting those commitments in a timely manner.