Basic information
- Standard SMILES
O=C(O)CN(CCOCCOCCN(CC(=O)O)CC(=O)O)CC(=O)O- InChIKey
DEFVIWRASFVYLL-UHFFFAOYSA-N- Molecular formula
- C14H24N2O10
- Average molar mass
- 380.35 g/mol
- Monoisotopic mass
- 380.14309497
Overview
Ethylene glycol bis(2-aminoethyl)tetraacetic acid is a diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively. It has a role as a chelator. It is a tetracarboxylic acid, a diether and a tertiary amino compound.
Names & identifiers
- Preferred name
- Egta
- IUPAC
- 2-[2-[2-[2-[bis(carboxymethyl)amino]ethoxy]ethoxy]ethyl-(carboxymethyl)amino]acetic acid
- English name
- Ethylenebis(oxyethylenenitrilo)tetraacetic acid
- Molecular formula
- C14H24N2O10
- Molecular weight
- 380.35
Names & synonyms
EGTA67-42-5Egtazic acidGedtaEthylenebis(oxyethylenenitrilo)tetraacetic acidEbontaAcide egtaziqueAcido egtazico6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)-Acidum egtazicumEthylene Glycol Tetraacetic Acid[Ethylenebis(oxyethylenenitrilo)]tetraacetic acid
Show more names
Ethylene Glyc1,2-bis(2-dicarboxymethylaminoethoxy)ethaneethylenedioxybis(ethyleneamino)tetraaceticacidAEGTGIETAEgtazic
DTXSID2045151Ethylenedioxybis(ethyleneamino)tetraacetic acidEthylene glycol bis(2-aminoethyl ether)tetraacetic acid(Ethylenebis(oxyethylenenitrilo))tetraacetic acidNSC-615010Ethylene glycol bis(aminoethyl ether)tetraacetate526U7A2651Glycoletherdiamine-N,N,N',N'-tetraacetic Acid
Database identifiers
- CAS
67-42-5- PubChem CID
- 6207
- DTXSID
DTXSID2045151- ChEMBL
CHEMBL240390- ChEBI
CHEBI:30740- UNII
- 526U7A2651
- EC Number
- 200-651-2
- Nikkaji
- J10.340C
Properties
Computed structural properties
- XLogP
- -6.2
- Topological polar surface area
- 174 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 12
- Rotatable bonds
- 17
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 397
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Chelating Agents
Physical DescriptionWhite powder; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 241 °C · 241 °C (dec.)(lit.)
- Boiling point
- 507.99 °C · 507.99°C (rough estimate)
- Density
- 1.2838 · 1.2838 (rough estimate)
- bulk density
- 450 kg/m3 · 450kg/m3
- refractive index
- 1.459 · 1.4590 (estimate)
- storage temp.
- room temp
- solubility
- 0.1 M · 0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
- form
- Crystalline Powder
- pka
- 1.47 · 1.47±0.10(Predicted)
- color
- White
- biological source
- synthetic (organic)
- Water Solubility
- slightly soluble
- Merck
- 14 · 14,3529
- BRN
- 1717370 · 1717370
- InChI
- 1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)
- InChIKey
- DEFVIWRASFVYLL-UHFFFAOYSA-N
- SMILES
- OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O
- CAS DataBase Reference
- 67 · 67-42-5(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 526 U7A2651 · 526U7A2651
- EPA Substance Registry System
- Ethylenebis(oxyethylenenitrilo)tetraacetic acid (67-42-5)
- Absorption
- 263 nm · cut-off at 263nm in 1 M NaOH at 0.1M
- UNSPSC Code
- 12352106 · 12352106
- NACRES
- 77 · NA.77
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 303 · H303
- Precautionary statements
- 270 · P270-P301+P312-P403-P501c
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- Hazard Codes
- Xi
- Risk Statements
- 36 · 36/37/38
- Safety Statements
- 24 · 24/25-36-26
- WGK Germany
- 2 · 2
- RTECS
- 3760000 · AH3760000
- TSCA
- TSCA listed
- HS Code
- 29225000 · 29225000
- Storage Class
- 11 · 11 - Combustible Solids
- Toxicity
- 50 orally · LD50 orally in Rabbit: 3587 mg/kg
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 83.3% (10 of 12) of all reports.
Warning
H315 (16.7%): Causes skin irritation [Warning Skin corrosion/irritation]
P264, P280, P302+P352, P321, P332+P317, and P362+P364 (click each P-code to see the statement)
Aggregated GHS information provided per 12 reports by companies from 3 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: 6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)-
EGTA: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryMay cause irritation; [Sigma-Aldrich MSDS] See Edetic acid.
Hazard Classes and CategoriesSkin Irrit. 2 (16.7%)
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 2
- tsca
- TSCA listed
- rtecs
- AH3760000
- hs_code
- 29225000
- Toxicity
- LD50 orally in Rabbit: 3587 mg/kg
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 24/25-36-26
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H303
- Precautionary statements
- P270-P301+P312-P403-P501c
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Agents counteracting or neutralizing the action of POISONS.
Substances that bind to and sequester CALCIUM ions.
Uses & manufacturing
UsesUsed as a metal chelator and reagent for maintaining calcium concentrations; [Merck Index] A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID. [ChemIDplus]
General Manufacturing Information6,9-Dioxa-3,12-diazatetradecanedioic acid, 3,12-bis(carboxymethyl)-: ACTIVE
Applications
DescriptionEthylenebis(oxyethylenenitrilo)tetraacetic acid is also named as Egtazic acid. It works as a chelating agent for the determination of calcium in the presence of magnesium.
UsesPharmaceutic aid. EGTA.
UsesEthylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid is a chelating agent used for making complexes, especially for calcium ions, which help to determine calcium in the presence of magnesium. It can be used experimentally for treating animals possessing cerium poisoning. It is useful in the separation of thorium from monazite. It also acts as a buffer and is used in protein purification.
UsesA chelating agent useful for the determination of calcium in the presence of magnesium.
Upstream & downstream products
Upstream raw materials
Suppliers50 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
北京华美互利生物化工010-56205725 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
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北京环宇世纪化学科技有限公司hysj_bj.com
上海喀露蓝科技有限公司18149758185 18149758185 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
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安倍医疗器械贸易（上海）有限公司400-1500-680 021-62402299 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
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Additional notes
DefinitionChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Related reactions
16 records
Linked notes
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