Basic information
- CAS
56391-57-2- Standard SMILES
CCN[C@@H]1C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@](C)(O)[C@H](NC)[C@H]1O.CCN[C@@H]1C[C@H](N)[C@@H](O[C@H]2OC(CN)=CC[C@H]2N)[C@H](O)[C@H]1O[C@H]1OC[C@](C)(O)[C@H](NC)[C@H]1O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O- InChIKey
AGFWIZQEWFGATK-UNZHCMSXSA-N- Molecular formula
- C42H92N10O34S5
- Average molar mass
- 1,441.6 g/mol
- Monoisotopic mass
- 1,440.4380959
Overview
Netilmicin Sulfate can cause developmental toxicity according to state or federal government labeling requirements.
Names & identifiers
- Preferred name
- Netilmicin Sulfate
- IUPAC
- bis((2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4-amino-3-[[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy]-6-(ethylamino)-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol);sulfuric acid
- English name
- Netilmicin sulfate
- Molecular formula
- C42H92N10O34S5
- Molecular weight
- 1441.55
Names & synonyms
NETILMICIN SULFATE56391-57-2NetromycinNetilmicin SulphateSch 20569Sch-20569S741ZJS97UCHEBI:7529NetromicineNetromicinaNetromycineNetrocin
Show more names
NETILMYCIN SULFATENetililnZetamicinNatimicin sulfateSulfate NetilMicinsulfate(2:5)(salt)Netromycin sulfate1-N-ETHYLSISOMICIN
D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)-O-(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1->4))-2-deoxy-N(sup 1)-ethyl-, sulfate (2:5) (salt)DTXCID6025484RefChem:56922Sch20569DTXSID8045484NTL sulfateCertomycinMFCD01311715
Database identifiers
- CAS
56391-57-2- PubChem CID
- 62115
- ChEMBL
CHEMBL3989829- ChEBI
CHEBI:7529- UNII
Properties
Computed structural properties
- Topological polar surface area
- 814 Ų
- Hydrogen bond donors
- 26
- Hydrogen bond acceptors
- 44
- Rotatable bonds
- 16
- Heavy atoms
- 91
- Formal charge
- 0
- Complexity
- 754
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 194 °C · >194°C (dec.)
- Boiling point
- 868 ℃ · 868℃
- storage temp.
- 2 · Inert atmosphere,2-8°C
- solubility
- 2 O: · H2O: soluble10mg/mL
- form
- Solid
- color
- white to faint yellow
- Water Solubility
- Soluble in water
- Sensitive
- Light Sensitive & Hygroscopic
- Stability
- Hygroscopic
- InChIKey
- AGFWIZQEWFGATK-ZHYOXECGNA-N
- FDA UNII
- 741 ZJS97U · S741ZJS97U
- Proposition 65 List
- Netilmicin Sulfate
- EPA Substance Registry System
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Danger
H312 (73.2%): Harmful in contact with skin [Warning Acute toxicity, dermal]
P203, P261, P271, P280, P302+P352, P304+P340, P317, P318, P321, P362+P364, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 56 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationHazard Traits - Developmental Toxicity
Hazard Classes and CategoriesAcute Tox. 4 (73.2%)
Safety data
- PPE
- Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
- wgk
- 3
- rtecs
- WK2286000
- hs_code
- 2941906000
- risk_code
- 61-20/21/22-60
- Signal word
- Danger
- Symbol(GHS)
- GHS08
- hazard_code
- T,Xi
- safety_code
- 53-36/37/39-45-37/39-36-26
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
- Hazard statements
- H360
- Hazard Classifications
- Repr. 1B
- Precautionary statements
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Compounds which inhibit the synthesis of proteins. They are usually ANTI-BACTERIAL AGENTS or toxins. Mechanism of the action of inhibition includes the interruption of peptide-chain elongation, the blocking the A site of ribosomes, the misreading of the genetic code or the prevention of the attachment of oligosaccharide side chains to glycoproteins.
Substances that inhibit the growth or reproduction of BACTERIA.
Applications
DescriptionNetilmicin Sulfate is the sulfate salt form of netilimicin, a member of the aminoglycoside family of antibiotics. Netilmicin is derived from sisomicin, a naturally occurring aminoglycoside antibiotic produced by the fermentation of Micromonospora inyoensis. It is an active aminoglycoside antibiotic against most Gram-negative and some Gram-positive bacteria, including certain strains resistant to gentamicin.
UsesNetilmicin sulfate is used as a broad spectrum antibiotic active against most Gram-negative and some Gram-positive bacteria. It is a semisynthetic 1-N-ethyl derivative of sisomycin, an aminoglycoside antibiotic with action similar to gentamicin, but has less ear and kidney toxicity. It is used to treat gram-negative bacterial infections, gonorrhea, skin infections, and other infectious diseases. Since netilmicin sulfate cannot be absorbed from the gut, it can only be administered by injection.
Upstream & downstream products
Upstream raw materials
Suppliers100 total
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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