Basic information
- CAS
67-71-0- Standard SMILES
CS(C)(=O)=O- InChIKey
HHVIBTZHLRERCL-UHFFFAOYSA-N- Molecular formula
- C2H6O2S
- Average molar mass
- 94.14 g/mol
- Monoisotopic mass
- 94.00885043
Overview
Sulfonyldimethane is a sulfone.
Names & identifiers
- Preferred name
- Dimethyl Sulfone
- IUPAC
- methylsulfonylmethane
- English name
- Dimethyl sulfone
- Molecular formula
- C2H6O2S
- Molecular weight
- 94.13
Names & synonyms
Dimethyl sulfoneMethyl sulfone67-71-0MethylsulfonylmethaneDimethyl sulphoneSulfonylbismethaneMethane, sulfonylbis-sulfonyldimethaneMETHYL SULFONYL METHANEMethylsulfonyl methaneDTXSID40439379H4PO4Z4FT
Show more names
MSMDMSO2(CH3)2SO2DimethylsulfonMethylSulfonylMethane(Msm)Dimethyl sulfone solutionMETHYLSULPHONE
NSC-63345CHEBI:9349DTXCID2023937NSC63345methyl sulfonmethaneMSM2000 PremiumSUL VITAL HOTRefChem:134278
Database identifiers
- CAS
67-71-0- PubChem CID
- 6213
- DTXSID
DTXSID4043937- ChEMBL
CHEMBL25028- ChEBI
CHEBI:9349- UNII
- 9H4PO4Z4FT
- EC Number
- 200-665-9
- Nikkaji
- J1.412E
Properties
Computed structural properties
- XLogP
- -0.4
- Topological polar surface area
- 42.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 0
- Heavy atoms
- 5
- Formal charge
- 0
- Complexity
- 85.3
Experimental & physicochemical properties
Chemical ClassesOther Classes -> Sulfur Compounds
DrugsPharmaceuticals -> Listed in ZINC15
CosmeticsSolvent
SpringerMaterials PropertiesSchoenflies notation
LogP-1.41
Density1.1700 @ 10°C
Dietary IngredientsMethylsulfonylmethane (MSM)
Human DrugsBreast Feeding; Lactation; Milk, Human; Anti-Inflammatory Agents
Boiling Point
237.00 to 239.00 °C. @ 760.00 mm Hg
238 °C @760 [mm Hg]
Melting Point109 °C
Vapor Pressure5.15 [mmHg]
Physical Description
Dry Powder
Solid; [Merck Index] White crystalline powder; Odorless; [Alfa Aesar MSDS]
Solid
Physicochemical properties
- Melting point
- 107 · 107-109 °C (lit.)
- Boiling point
- 238 °C · 238 °C (lit.)
- Density
- 1 · 1,16 g/cm3
- bulk density
- 880 kg/m3 · 880kg/m3
- refractive index
- 1.4226 · 1.4226
- Flash point
- 290 °F · 290 °F
- storage temp.
- 30 °C · Store below +30°C.
- solubility
- 150 g/l · 150g/l
- pka
- 28 · 28(at 25℃)
- form
- Crystals or Crystalline Powder
- color
- White
- Odor
- 1 % · at 1.00%. sulfurous burnt
- Water Solubility
- 150 g/L · 150 g/L (20 ºC)
- Specific Heat Capacity
- 1.06 J/ · Cp(gas): 1.06 J/(g·K), at 25℃
- Merck
- 14 · 14,3258
- BRN
- 1737717 · 1737717
- Henry's Law Constant
- 5 · 5.0×10-3 mol/(m3Pa) at 25℃, Mackay et al. (2006)
- Stability
- Stable. Combustible. Incompatible with strong oxidizing agents.
- Cosmetics Ingredients Functions
- SOLVENTVISCOSITY CONTROLLING
- InChI
- 1S/C2H6O2S/c1-5(2,3)4/h1-2H3
- InChIKey
- HHVIBTZHLRERCL-UHFFFAOYSA-N
- SMILES
- CS(C)(=O)=O
- LogP
- -1.074 · -1.074 (est)
- CAS DataBase Reference
- 67 · 67-71-0(CAS DataBase Reference)
- EWG's Food Scores
- 1 · 1
- FDA UNII
- 9 H4PO4Z4FT · 9H4PO4Z4FT
- NIST Chemistry Reference
- Dimethyl sulfone(67-71-0)
- EPA Substance Registry System
- Dimethyl sulfone (67-71-0)
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 24 · NA.24
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302
- Precautionary statements
- 501 · P501-P270-P264-P301+P312+P330
- PPE
- 95 · Eyeshields, Gloves, type N95 (US)
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 1 · 1
- RTECS
- 2785000 · PB2785000
- TSCA
- TSCA listed
- HS Code
- 29309070 · 29309070
- Storage Class
- 11 · 11 - Combustible Solids
- Toxicity
- 50 orally · LD50 orally in Rabbit: 17000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
- REACH Registrations
- Active
Safety & regulation
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 96.1% (122 of 127) of all reports.
Not Classified
Aggregated GHS information provided per 127 reports by companies from 5 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory Information
Chemical: Methane, sulfonylbis-
Methane, 1,1'-sulfonylbis- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Methane, 1,1'-sulfonylbis- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 04-08-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/17580
Dimethyl sulfone: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryNo evidence of teratogenicity in rats; [REPROTOX] Not a skin irritant; May cause eye irritation; [Alfa Aesar MSDS] See Dimethyl sulfoxide. See Dipropyl sulfone.
Hazard Classes and CategoriesNot Classified
Safety & protection
Protective Action Criteria (PAC)
15 [mg/m3]
170 [mg/m3]
990 [mg/m3]
Toxicology
Effects During Pregnancy and Lactation◉ Summary of Use during Lactation
Safety data
- PPE
- Eyeshields, Gloves, type N95 (US)
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- PB2785000
- hs_code
- 29309070
- Toxicity
- LD50 orally in Rabbit: 17000 mg/kg LD50 dermal Rabbit > 5000 mg/kg
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H302
- REACH Registrations
- Active
- Precautionary statements
- P501-P270-P264-P301+P312+P330
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationSubstances that reduce or suppress INFLAMMATION.
Tissue LocationsBrain
Cellular LocationsCytoplasm
Uses & manufacturing
UsesOccurs in some plants and in the adrenal cortex of cattle; Used as a solvent; [Merck Index] A metabolite of dimethyl sulfoxide that naturally occurs in many foods; Marketed as a dietary supplement for promotion of joint health; [REPROTOX]
U.S. Production2023: 67,460 lb
Consumer UsesSoil amendments (fertilizers)
Use ClassificationCosmetics -> Solvent
General Manufacturing InformationMethane, 1,1'-sulfonylbis-: ACTIVE
Applications
UsesUse as high temperature solvent inorganic and organic substances, organic chemical raw materials, food additives and health products raw materials, also used as gas chromatography stationary phase (maximum use temperature 30 ℃, acetone as solvent) and analytical reagents.
UsesDimethyl sulfone is used as a high-temperature solvent for both inorganic and organic substances. It acts as an intermediate as well as medium in organic synthesis. It plays an important role as a carbon source by the airborne bacteria Afipia. It is also employed as an extraction solvent for the separation of aromatic compounds like benzene, toluene and xylenes from aliphatic hydrocarbons. Further, it is used in the polymerization process. It finds application in pharmaceuticals, agrochemicals, paint and coating materials.
UsesDimethyl sulfone is a high tempereture solvent for many inorganic and organic substances,it is used as antiinflammatory, antiproliferative, antiparasitic.
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers100 total
国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
INTATRADE GmbH+49 3493/605464 · [email protected]
南京兰亚化工贸易有限公司+86-25-8331-5620 · [email protected]
科瑞迪化学400-821-5857 021-64326257 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
Syntechem Co.,Ltd[email protected]
上海迈瑞尔生化科技有限公司4006356688 18621169109 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
阿法埃莎（中国）化学有限公司400-6106006 · [email protected]
安耐吉化学&3A（安徽泽升科技股份有限公司）400-0056266 · [email protected]
上海瀚鸿科技股份有限公司021-54306202 13764082696 · [email protected]
嘉兴市艾森化工有限公司0573-85285100 18627885956 · [email protected]
上海攀鸿化工科技有限公司021-56491756 13512199871 · [email protected]
合肥天健化工有限公司551-65418679 15856988503;15837135945 · [email protected]
孝感深远化工有限公司15527621225; 15527621225 · [email protected]
Beckmann-Kenko GmbH+49 4241 9308 88 · [email protected]
山东西亚化学有限公司13355009207 13355009207 · [email protected]
玛雅试剂+86 (573) 82222445 (0)18006601000 452520369 · [email protected]
四川库利南科技有限公司400-1166-196 18981987031 · [email protected]
上海耐士化工科技有限公司400-188-0725 +86 21 34310725 13611771617
天津希恩思生化科技有限公司400 638 7771 · [email protected]
衡水昊业科技有限公司0318-2012300 +86-18632882519 · [email protected]
斯百全化学（上海）有限公司021-021-021-67601398-809-809-809 15221380277 · [email protected]
艾科试剂4008-755-333 18080918076 · [email protected]
上海思域化工科技有限公司86-21-34053660 · [email protected]
赛默飞世尔科技（中国）有限公司800-810-5118 · [email protected]
北京伊诺凯科技有限公司400-810-7969 010-59572699 · [email protected]
江苏艾康生物医药研发有限公司025-66113011 13913916777 · [email protected]
TCI AMERICA800-4238616 · [email protected]
TOKYO CHEMICAL INDUSTRY CO., LTD.03-36680489 · [email protected]
TCI Europe320-37350700 · [email protected]
深圳振强药物研发有限公司0755-66853366 13670046396 · [email protected]
南京杜莱生物技术有限公司025-84699383-8003;025-846993838003-8003 18013301590 · [email protected]
上海陶素生化科技有限公司021-33632979 · [email protected]
上海将来实业股份有限公司400-0066400 13621662912 · [email protected]
安徽科迪达化工有限公司0554-2106669 · [email protected]
日照力德士化工有限公司010-51268198 · [email protected]
美岚实业（上海）有限公司021-58958189 · [email protected]
上海石洋化工有限公司021-56795766 · [email protected]
成都零六生物科技有限公司400-1166-196 13458535857 · [email protected]
上海馨远医药科技有限公司021-24206007 13764915196 · [email protected]
上海御略医药科技有限公司021-60345187 13671753212 · [email protected]
上海麦克林生化科技股份有限公司15221275939 15221275939 · [email protected]
杭州杰恒化工有限公司0571-87396432 · [email protected]
上海有朋化工有限公司021-69005955 13701776567 · [email protected]
北京海力扬化学科技有限公司13718199399 · [email protected]
北京欣赛维化学科技有限公司010-56218822 13717722232 · [email protected]
四川海诺威科技有限公司13708085536 13708085536 · [email protected]
Additional notes
DefinitionChEBI: Sulfonyldimethane is a sulfone.
Related reactions
176 records
Compound notes
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