Ammonium Lactate

HCID 62358CAS 515-98-0

Basic information

Standard SMILES
CC(O)C(=O)[O-].[NH4+]
InChIKey
RZOBLYBZQXQGFY-UHFFFAOYSA-N
Molecular formula
C3H6O3.H3N
Average molar mass
107.11 g/mol
Monoisotopic mass
107.05824315

Overview

Ammonium lactate appears as white solid or liquid. Has no odor. Sinks and mixes with water. (USCG, 1999)

Names & identifiers

Preferred name
Ammonium Lactate
IUPAC
azanium 2-hydroxypropanoate
English name
Ammonium Lactate
Molecular formula
C3H9NO3
Molecular weight
107.11

Names & synonyms

Ammonium lactate515-98-0LacHydrinammonium 2-hydroxypropanoateAmlactinLaclotionKerasal ALPropanoic acid, 2-hydroxy-, monoammonium salt52003-58-4Lac hydrinLactic acid ammonium salt67M901L9NQ
Show more names
Ammonium lactate (usan)D02920CH(OH)CO2NH4Lac-hydrin (tn)PURASAL(R) NH 70Ammonium L-lactateAmmoniumlaktat-LungLactic acid ammoniumammonium lactate 60%
BMS-186091Propanoic acid, 2-hydroxy-, ammonium salt (1:1)DTXSID3052808NSC-760427Geri-HydrolacUltravate XRefChem:58663AMMONIUM LACTATE SYRUP

Database identifiers

CAS
515-98-0、52003-58-4
PubChem CID
62358
DTXSID
DTXSID3052808
ChEMBL
CHEMBL1200747
UNII
67M901L9NQ
EC Number
208-214-8、856-973-4

Properties

Computed structural properties

Topological polar surface area
61.4 Ų
Hydrogen bond donors
2
Hydrogen bond acceptors
3
Rotatable bonds
0
Heavy atoms
7

Experimental & physicochemical properties

Chemical ClassesNitrogen Compounds -> Ammonium Compounds
Cosmetics · 2 items

Cosmetic ingredients (Ammonium Lactate) -> CIR (Cosmetic Ingredient Review)

Buffering

Density1.2 at 59 °F (USCG, 1999) - Denser than water; will sink
Human Drugs · 2 items

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Melting Point92 °C
Physical Description · 3 items

Ammonium lactate appears as white solid or liquid. Has no odor. Sinks and mixes with water. (USCG, 1999)

Liquid; Liquid; Other Solid

White solid or liquid; Odorless; [CHRIS] 68-72% Aqueous solution: Light yellow liquid; [PURAC Bioquimica MSDS]

Physicochemical properties

Melting point
91 · 91-94 °C
Boiling point
74 °C · 74 °C(Press: 0.14 Torr)
Density
1.054 g/mL · 1.054 g/mL at 25 °C
refractive index
20 · n20/D 1.363
storage temp.
-20 °C · Store at -20°C
form
Liquid

Safety & regulation

GHS classification

GHS Classification · 6 items

This chemical does not meet GHS hazard criteria for 87.6% (415 of 474) of all reports.

Warning

H315 (12.2%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 474 reports by companies from 6 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Warning

Hazard information

Regulatory Information · 3 items

Chemical: Propanoic acid, 2-hydroxy-, monoammonium salt

Propanoic acid, 2-hydroxy-, ammonium salt (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Propanoic acid, 2-hydroxy-, ammonium salt (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Ammonium lactate: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Propanoic acid, 2-hydroxy-, monoammonium salt: Human health tier I assessment
Fire HazardsSpecial Hazards of Combustion Products: Toxic oxides of nitrogen may be formed in a fire. (USCG, 1999)
Health HazardsInhalation causes irritation of nose and throat. Contact with eyes causes irritation. (USCG, 1999)
Hazards Summary · 1 item

Causes tremors, muscle weakness, and altered gastric secretion in acute oral studies of cattle; [RTECS] A skin, eye, nose, and throat irritant; Harmful by ingestion; [CHRIS] Not to be used in infant foods; [JECFA] Not considered to pose any health hazards; [PURAC Bioquimica MSDS]

Reactive GroupSalts, Acidic

Safety & protection

Fire FightingFire Extinguishing Agents: Water, foam (USCG, 1999)
First AidINHALATION: remove to fresh air.
Protective Action Criteria (PAC) · 3 items

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

Personal Protective Equipment (PPE)Dust mask; goggles or face shield; rubber gloves (USCG, 1999)

Toxicology

Toxicity Summary · 2 items

Based on the available information included in this report, the CIR Expert Panel concludes that Glycolic and Lactic Acid, their common salts and their simple esters, are safe for use in cosmetic products at concentrations less than or equal to 10%, at final formulation pH greater than or equal to 3.5, when formulated to avoid increasing sun sensitivity or when directions for use include the daily use of sun protection. These ingredients are safe for use in salon products at concentrations less than or equal to 30%, at final formulation pH greater than or equal to 3.0, in products designed for brief, discontinuous use followed by thorough rinsing from the skin, when applied by trained professionals, and when application is accompanied by directions for the daily use of sun protection...Ammonium Lactate...

Safe for use in cosmetics, with qualifications

Safety data

PPE
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
wgk
-
tsca
TSCA listed
Signal word
Warning
Symbol(GHS)
GHS07
Storage Class
10 - Combustible liquids

Chemistry & industry

Pharmacology

ATC CodeQA - Alimentary tract and metabolism
Pharmacodynamics · 1 item

Lactic acid is an alpha-hydroxy acid. It is a normal constituent of tissues and blood. The alpha-hydroxy acids (and their salts) may act as humectants when applied to the skin. This property may influence hydration of the stratum corneum. In addition, lactic acid, when applied to the skin, may act to decrease corneocyte cohesion.

Mechanism of ActionUnknown.
FDA Pharmacological Classification · 6 items

67M901L9NQ

AMMONIUM LACTATE

Established Pharmacologic Class [EPC] - alpha-Hydroxy Acid

Chemical Structure [CS] - Hydroxy Acids

Ammonium lactate is an alpha-Hydroxy Acid.

AMMONIUM LACTATE

Absorption, Distribution and ExcretionIn vitro study of percutaneous absorption of ammonium lactate lotion, 12% using human cadaver skin indicates that approximately 5.8% of the material was absorbed after 68 hours.

Uses & manufacturing

Uses · 2 items

CIR ingredient: Ammonium Lactate

Permitted for use as an inert ingredient in non-food pesticide products; [EPA] Used in skin moisturizers; [ExPub: TERIS] Used to regulate acidity in foods and to treat flour; [JECFA] Used as an additive to cosmetics and specialty chemical; [PURAC Bioquimica MSDS]

U.S. Production2023: 243,327 lb
Consumer UsesHumectant
Industry UsesHumectant
Use Classification · 2 items

Food Additives -> ACIDITY_REGULATOR; FLOUR_TREATMENT_AGENT -> JECFA Functional Classes

Cosmetics -> Buffering

General Manufacturing Information · 2 items

All Other Chemical Product and Preparation Manufacturing

Propanoic acid, 2-hydroxy-, ammonium salt (1:1): ACTIVE

Applications · 5 items

DescriptionAmmonium lactate is a compound with formula NH4(C2H4(OH)COO). It is the ammonium salt of lactic acid. It has E number "E328" and is the active ingredient of the skin lotions Amlactin and Lac-Hydrin.

UsesAntipruritic (topical).

UsesAmmonium lactate solution has been used in the ammonium lactate fermentation broth for the concentration of organic acid salts by conventional electrodialysis (EDC).

UsesWhen ammonium lactate is applied topically, it is found to thicken the viable epidermis while reducing the thickness of the stratum corneum layer. It is a neutralized version of lactic acid.

General DescriptionAmmonium lactate is an ammonium salt of lactic acid. It is generally used as a feedstock for ethyl lactate and as a component of moisturizers.

Upstream & downstream products

Downstream products

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
湖北永阔科技有限公司027-59223108 15972152991 · [email protected]
上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]
湖北万得化工有限公司15377098680 15377098680 · [email protected]
Hebei Chuanghai Biotechnology Co., Ltd+86-17732866630 · [email protected]

Related reactions

13 records

Linked notes

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