HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cuprous chloride
COPPER CHLORIDE · COPPER ATOMIC SPECTROSCOPY STANDARD · Un2802 · HAMP-OL · Kirticopper · CUPRIC CHLORIDE · Einecs 215-704-5 · Copper, diaquadichloro-
Identifiers & Physical Properties
| CAS No. | 1344-67-8 |
|---|---|
| Molecular formula | ClCu |
| Average molar mass | 99 g/mol |
| SMILES | [Cl][Cu] |
| InChIKey | OXBLHERUFWYNTN-UHFFFAOYSA-M |
| PubChem CID | 62652 |
| ChEBI | CHEBI:53472 |
Chemical & Physical Properties
| Topological polar surface area | 0 |
|---|---|
| Hydrogen bond donors | 0 |
| Hydrogen bond acceptors | 0 |
| Rotatable bonds | 0 |
| Heavy atoms | 2 |
| Formal charge | 0 |
| Complexity | 2 |
| Chemical classes | Metals -> Metals, Inorganic Compounds |
| SpringerMaterials Properties | thermal expansion coefficient |
| Density | 4.14 @25 °C3.386 g/mL at 25 °C(lit.) |
| Boiling point | 1490 °C @760 [mm Hg]993 °C |
| Melting point | 423 °C620 °C(lit.) |
| Vapor pressure | 1 [mm Hg] @546 °C |
| Physical Description | Dry PowderLiquidWhite solidTurns green on exposure to moist air, and blue to brown on exposure to light[Merck Index] Insoluble in water (0.1 g/L)[Ullmann] Grey-tan to light green odorless powder[Reference #2] |
| Storage conditions | 2-8°C |
| Solubility | H2O: soluble |
| Physical state | powder |
| InChI | InChI=1S/ClH.Cu/h1H |
| InChIKey | NNIYFVYSVUWTOA-UHFFFAOYSA-N |
| SMILES | Cl.[Cu] |
| CAS DataBase Reference | 1344-67-8(CAS DataBase Reference) |
| FDA UNII | S2QG84156O |
| EPA Substance Registry System | Copper chloride (1344-67-8) |
| GHS pictogram | GHS06 |
| Signal word | Danger |
| GHS hazard statements | H301-H335-H319-H315 |
| GHS precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
| Hazard symbols | N |
| Risk statements (R) | 52/53 |
| Safety statements (S) | 61 |
| UN transport number | UN 3264 8/PG 3 |
| Water hazard class (WGK) | 2 |
| RTECS number | GL7000000 |
| F | 3 |
| TSCA inventory status | TSCA listed |
Safety & Regulations
| GHS classification | WarningH302: Harmful if swallowed [Warning Acute toxicity, oral]P264, P270, P273, P301+P317, P330, P391, and P501 (click each P-code to see the statement)H317: May cause an allergic skin reaction [Warning Sensitization, Skin]P260, P261, P272, P273, P280, P302+P352, P319, P321, P333+P317, P362+P364, P391, and P501 (click each P-code to see the statement) |
|---|---|
| Regulatory information | Chemical: Copper chloride (CuCl)Copper chloride (CuCl) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Copper chloride (CuCl) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)Copper (I) chloride: Does not have an individual approval but may be used under an appropriate group standard |
| Other safety information | IMAP assessments - Copper chloride (CuCl): Human health tier I assessment |
| Hazards summary | Harmful if swallowed[MSDSonline] Acute copper poisoning after ingestion can cause liver injury, methemoglobinemia, and hemolytic anemia. Acute renal failure may result, secondary to massive hemoglobinuria. [Goldfrank, p. 1259] Classified as category I for skin and eye irritation (corrosive)Category II for acute oral and dermal exposure (moderate toxicity)Category III for acute inhalation exposure (low toxicity)Positive results in dermal sensitization studies[Reference #2] May cause irritationHarmful by ingestion[Alfa Aesar MSDS] See Copper. |
| DOT Hazard Classification | Cuprous chlorideSevere marine pollutant |
| Hazard Classes and Categories | Acute toxicity (Oral) - Category 3Skin sensitization - Category 1Acute Tox. 4 * |
| Exposure control and personal protection | 0.01 [mg/m3], respirable fraction (Cu, inorganic cmpnds)[German Research Foundation (DFG)] |
| Minimum Risk Level | Acute Oral: 0.01 mg/kg/day (L134) Intermediate Oral: 0.01 mg/kg/day (L134) |
| Threshold Limit Values (TLV) | 1.0 [mg/m3], as Cu |
| Permissible Exposure Limit (PEL) | 1.0 [mg/m3], as Cu |
| Protective Action Criteria (PAC) | 0.093 [mg/m3]4.6 [mg/m3]28 [mg/m3] |
| Immediately Dangerous to Life or Health (IDLH) | 100.0 [mg/m3], as Cu |
| Treatment | EYES: irrigate opened eyes for several minutes under running water. INGESTION: do not induce vomiting. Rinse mouth with water (never give anything by mouth to an unconscious person). Seek immediate medical advice. SKIN: should be treated immediately by rinsing the affected parts in cold running water for at least 15 minutes, followed by thorough washing with soap and water. If necessary, the person should shower and change contaminated clothing and shoes, and then must seek medical attention. INHALATION: supply fresh air. If required provide artificial respiration. |
| Health effects | People must absorb small amounts of copper every day because copper is essential for good health, however, high levels of copper can be harmful. Very-high doses of copper can cause damage to your liver and kidneys, and can even cause death. Copper may induce allergic responses in sensitive individuals. (L278, L279) |
| Adverse effects | Occupational hepatotoxin - Secondary hepatotoxins: the potential for toxic effect in the occupational setting is based on cases of poisoning by human ingestion or animal experimentation. |
| Exposure routes | Oral (L277)inhalation (L277)dermal (L277) |
| Toxicity summary | Excess copper is sequestered within hepatocyte lysosomes, where it is complexed with metallothionein. Copper hepatotoxicity is believed to occur when the lysosomes become saturated and copper accumulates in the nucleus, causing nuclear damage. This damage is possibly a result of oxidative damage, including lipid peroxidation. Copper inhibits the sulfhydryl group enzymes such as glucose-6-phosphate 1-dehydrogenase, glutathione reductase, and paraoxonases, which protect the cell from free oxygen radicals. It also influences gene expression and is a co-factor for oxidative enzymes such as cytochrome C oxidase and lysyl oxidase. In addition, the oxidative stress induced by copper is thought to activate acid sphingomyelinase, which lead to the production of ceramide, an apoptotic signal, as well as cause hemolytic anemia. Copper-induced emesis results from stimulation of the vagus nerve. (L277, T49, A174, L280) |
| Signs and Symptoms | Breathing high levels of copper can cause irritation of the nose and throat. Ingesting high levels of copper can cause nausea, vomiting, diarrhea, headache, dizziness, and respiratory difficulty. (L278, L279) |
| Carcinogen Classification | No indication of carcinogenicity to humans (not listed by IARC). |
| Toxicity Data | LC50 (mice) = 1,008 mg/m3LD50: 140 mg/kg (Oral, Rat) (L335) LD50: 100 mg/kg (Subcutaneous, Guinea pig) (L335) LC50: 1008 mg/kg (Inhalation, Mouse) (L335) |
| F | 3 |
| Water hazard class (WGK) | 2 |
| TSCA inventory status | TSCA listed |
| RTECS number | GL7000000 |
| UN transport number | UN 3264 8/PG 3 |
| Risk statements (R) | 52/53 |
| Signal word | Danger |
| GHS pictogram | GHS06 |
| Hazard symbols | N |
| Safety statements (S) | 61 |
| GHS hazard statements | H301-H335-H319-H315 |
| GHS precautionary statements | P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362 |
Applications & Uses
Uses
Isomerization and cracking catalyst, mordant in dyeing and printing fabrics, sympathetic ink, disinfectant, pyrotechnics, wood preservation, fungicides, metallurgy, preservation of pulpwood, deodorizing and desulfurizing petroleum distillates, photography, water purification, feed additive, electroplating baths, pigment for glass and ceramics, acrylonitrile manufacturing.
Preparation & Synthesis
Preparation
Cupric chloride can be prepared by reacting hydrochloric acid with copper oxide CuO or copper carbonate (actually basic copper carbonate Cu(OH)2·CuCO3).