Basic information
- CAS
9002-68-0- Standard SMILES
CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(C(=O)N2CCCC2C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(C(C)O)NC1=O- InChIKey
ZDRRIRUAESZNIH-UHFFFAOYSA-N- Molecular formula
- C42H65N11O12S2
- Average molar mass
- 980.2 g/mol
- Monoisotopic mass
- 979.4255589
Overview
Urofollitropin can cause developmental toxicity according to state or federal government labeling requirements.
Names & identifiers
- Preferred name
- Follicle Stimulating Hormone
- IUPAC
- 1-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide
- English name
- Follicle stimulating hormone
- Molecular formula
- NULL
- Molecular weight
- 0
Names & synonyms
Follicle-stimulating hormoneRefChem:599581DTXSID3040483FSH (Follicle Stimulating Hormone)FOLLICLE-STIMULATING HORMONE [MI]FOLLICLE STIMULATING HORMONE [VANDF]FOLLICLE STIMULATING HORMONE [GREEN BOOK]Follicle Stimulating Hormone146479-72-31-[19-amino-7-(2-amino-2-oxoethyl)-13-butan-2-yl-10-(1-hydroxyethyl)-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]-N-[1-[(2-amino-2-oxoethyl)amino]-4-methyl-1-oxopentan-2-yl]pyrrolidine-2-carboxamide26995-91-5Fertinex; Fertinorm; Metrodin; Orgafol; Urofollitrophin
Show more names
FSHfollitropinmenotrophinUROFOLLITROPHINHFSHpFSHfsh-phebinRAT FSHprolanb
SCHEMBL19712185ZDRRIRUAESZNIH-UHFFFAOYSA-NAT36867DA-78798Q4006490
Properties
Computed structural properties
- XLogP
- -1.5
- Topological polar surface area
- 427 Ų
- Hydrogen bond donors
- 12
- Hydrogen bond acceptors
- 15
- Rotatable bonds
- 15
- Heavy atoms
- 67
- Formal charge
- 0
- Complexity
- 1,790
Experimental & physicochemical properties
Animal DrugsFDA approved animal drugs -> Active ingredient
Physicochemical properties
- storage temp.
- 2 · 2-8°C
- solubility
- 2 O: · H2O: 50 mg/mL, soluble
- form
- white powder
- color
- White to off-white
- PH
- 7.4 · 7.4
- biological source
- human pituitary glands
- Water Solubility
- 50 g/L · water: ~50g/L
- Merck
- 13 · 13,4249
- Specific Activity
- 2000 IU/mg · ≥2000IU/mg
- NCI Dictionary of Cancer Terms
- follitropin; FSH
- FDA UNII
- 8 FYM5179QJ · 8FYM5179QJ
- EPA Substance Registry System
- Gonadotropin, menopausal(9002-68-0)
- UNSPSC Code
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Hazard information
Regulatory InformationFollicle stimulating hormone: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Safety data
- F
- 10-21
- wgk
- 3
- rtecs
- LP6330000
- hazard_code
- B
- safety_code
- 22-24/25
- Storage Class
- 11 - Combustible Solids
- Hazardous Substances Data
- 9002-68-0(Hazardous Substances Data)
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
Applications
DescriptionGonal-F was launched in Austria, Germany, Denmark, Ireland, Italy, Norway, Sweden, Switzerland, France and the UK for the treatment of infertility. The recombinant follicule stimulating hormone (recFSH) was produced by introducing the genes for the α- and β-FSH subunits into the genome of Chinese hamster ovary cells. The isolated recFSH was a glycosylated bioactive dimer that appeared to be identical to urinary human FSH. Biochemically, the recFSH was equal to or slightly better to the uroFSH. The ultra-high purity of recFSH makes it less prone to side effects from contaminants in uroFSH and can be injectable.
DescriptionPuregon was launched in Denmark, Germany and the UK for ovulation induction in clomiphene-resistent anovulation and controlled ovarian hyperstimulation. Transfected Chinese hamster ovary cells with plasmids containing the genes encoding the α- and β-FSH subunits produced recFSH that was similar to uroFSH. In both cases (follitropin α and β) no antibody formation was detected, however, this form appeared to be more active than follitropin α in that there was a 25% greater pregnancy rate compared to uroFSH.
UsesA major gonadotropin secreted by the adenohypophysis (PITUITARY GLAND, ANTERIOR). Follicle-stimulating hormone stimulates GAMETOGENESIS and the supporting cells such as the ovarian GRANULOSA CELLS, the testicular SERTOLI CELLS, and LEYDIG CELLS. FSH consi
UsesFollicle stimulating hormone (FSH) from human pituitary has been used for-in vitro luteinization of Macaque granulosa cellsluteal cell proliferation assayculturing of preantral follicle cells obtained from micein vitro maturation of immature cumulus-oocyte complexes (COCs) obtained from mice andculture of RAW264.7 cell line
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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