Basic information
- CAS
27214-00-2- Standard SMILES
O=P([O-])([O-])OC(CO)CO.[Ca+2]- InChIKey
UHHRFSOMMCWGSO-UHFFFAOYSA-L- Molecular formula
- C3H7CaO6P
- Average molar mass
- 210.14 g/mol
- Monoisotopic mass
- 209.9606158
Overview
Calcium glycerophosphate is an organic calcium salt having glycerol 2-phosphate(2) as the counterion. It contains a glycerol 2-phosphate(2-).
Names & identifiers
- Preferred name
- Calcium Glycerophosphate
- IUPAC
- calcium 1,3-dihydroxypropan-2-yl phosphate
- English name
- CALCIUM GLYCEROPHOSPHATE
- Molecular formula
- C3H7CaO6P
- Molecular weight
- 210.14
Names & synonyms
calcium 1,3-dihydroxypropan-2-yl phosphatebeta-glycerophosphoric acid calcium saltXWV9Z12C1C1,2,3-Propanetriol, mono(dihydrogen phosphate) calcium saltCHEBI:313361,2,3-Propanetriol, mono(dihydrogen phosphate), calcium salt (1:1)Glycerol, mono(dihydrogen phosphate), calcium salt (1:1)NEROZINNEUROSINPRELIEFGlycerophosphate, CalciumRefChem:573473
Show more names
Calcium GlycerophosphoricCALCIUM GLYCEROPHOSPHATE POWDERGlycerol phosphate calcium saltBETA-GLYCEROPHOSPHATE CALCIUM SALTCalucium Glycerophosphate
DTXSID20873177248-328-5249-312-027214-00-2Calcium GlycerophosphateCalcium glycerylphosphateCalcium beta-glycerophosphate58409-70-4
Database identifiers
- CAS
27214-00-2、58409-70-4- PubChem CID
Properties
Computed structural properties
- Topological polar surface area
- 113 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 3
- Heavy atoms
- 11
- Formal charge
- 0
- Complexity
- 113
Experimental & physicochemical properties
CosmeticsOral care; Antiplaque
Food AdditivesNUTRIENT SUPPLEMENT, STABILIZER OR THICKENER -> FDA Substance added to food
SolubilitySoluble
Melting PointDecomposes at 170
Food Contact SubstancesFCS -> FDA Inventory of Food Contact Substances Listed in 21 CFR
Physicochemical properties
- Melting point
- 170 ℃ · > 170℃
- Density
- 1.82 · 1.82-1.855[at 20℃]
- vapor pressure
- 0 Pa · 0Pa at 25℃
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Sparingly soluble in water, practically insoluble in ethanol (96 per cent).
- form
- powder to crystal
- color
- White to Almost white
- Water Solubility
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 97.4% (74 of 76) of all reports.
Not Classified
Aggregated GHS information provided per 76 reports by companies from 3 notifications to the ECHA C&L Inventory.
This chemical does not meet GHS hazard criteria for 2.6% (1 of 39) of reports.
Warning
H315 (97.4%): Causes skin irritation [Warning Skin corrosion/irritation]
Hazard information
Regulatory Information
Chemical: 1,2,3-Propanetriol, mono(dihydrogen phosphate), calcium salt (1:1)
REACH registered substance: Calcium glycerophosphate (EC: 248-328-5)
Calcium Glycerophosphate: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Other Safety InformationIMAP assessments - 1,2,3-Propanetriol, mono(dihydrogen phosphate), calcium salt (1:1): Human health tier I assessment
Hazard Classes and Categories
Not Classified
Skin Irrit. 2 (97.4%)
Safety data
- tsca
- TSCA listed
- hs_code
- 2919.90.5050
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- safety_code
- 22-24/25
- Hazard statements
- H302
- REACH Registrations
- Active
Chemistry & industry
Pharmacology
ATC Code
A - Alimentary tract and metabolism
QA - Alimentary tract and metabolism
Pharmacodynamics
It is thought that calcium glycerophosphate may act through a variety of mechanisms to produce an anti-caries effect. These include increasing acid-resistance of the enamel, increasing enamel mineralization, modifying plaque, acting as a pH-buffer in plaque, and elevating [DB01373] and phosphate levels. When used as an electrolyte replacement, calcium glycerophosphate donates [DB01373] and inorganic phosphate. Calcium glycerophosphate is preferable to calcium phosphate due to its increased solubility. Compared to combination calcium gluconate and potassium phosphate, calcium glycerophosphate produces greater phosphate retention which allows for increased [DB01373] retention and ultimately greater incorporation of the ions into bone structure.
Mechanism of Action
Calcium glycerophosphate in combination with sodium monofluorophosphate was found to reduce the acid solubility of enamel. This is thought to be due to increased uptake of fluoride in a non-alkali soluble form at the expense of a fraction remaining in the alkali-soluble form of calcium fluoride. It is also thought that calcium glycerophosphate enhances the remineralization effect of sodium monofluorophosphate leading to greater remineralization of enamel but the mechanism behind this is unknown. Calcium glycerophosphate reduces the decrease in plaque pH produced by sucrose solutions. This may be due to the buffering action of donated phosphate which acts as an acceptor to three hydrogen ions to form biphosphate, dihydrogen phosphate, and finally phosphoric acid. As bisphosphate and dihydrogen phosphate are amphoteric, these molecules can act as buffers against both acids and bases. Studies on plaque-modification by calcium glycerophosphate have been inconsistent. Redections in plaque weight and plaque area have been noted in separate studies but neither has been confirmed and no causative link has been established in regards to calcium glycerophosphate's anti-caries effect. Calcium glycerophosphate donates [DB01373] and inorganic phosphate resulting in elevated levels of the ions in plaque. These ions are important components of the mineral structure of teeth. As such, their presence supports maintenance of healthy tooth structure and mineralization. In electrolyte replacement calcium glycerophosphate again acts as a donor of [DB01373] and phosphate. See [DB11348] for pharmacological descriptions of calcium and phosphate.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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