Basic information
- CAS
3546-03-0- Standard SMILES
CC(CN(C)C)CN1c2ccccc2Sc2ccc(C#N)cc21- InChIKey
SLFGIOIONGJGRT-UHFFFAOYSA-N- Molecular formula
- C19H21N3S
- Average molar mass
- 323.5 g/mol
- Monoisotopic mass
- 323.14561886
Overview
Cyamemazine is a member of phenothiazines.
Names & identifiers
- Preferred name
- Cyamemazine
- IUPAC
- 10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrile
- English name
- cyamemazine
- Molecular formula
- C19H21N3S
- Molecular weight
- 323.46
Names & synonyms
Cyamemazine3546-03-0CyamepromazineTercianKyamepromazineCiamemazinaRP-7204CyamemazinumRP 7204A2JGV5CNU4TH-260210-(3-(Dimethylamino)-2-methylpropyl)phenothiazine-2-carbonitrile
Show more names
7204 RPCiaMatilCianatilCyaMeMazinF. I. 62297204 R. E.
10-[3-(dimethylamino)-2-methylpropyl]phenothiazine-2-carbonitrileFL-622910-(3-dimethylamino-2-methylpropyl)phenothiazine-2-carbonitrilecyamamazine2-Cyano-10-(3-dimethylamino-2-methylpropyl)phenothiazineRefChem:580103N05AA06222-594-2
Database identifiers
- CAS
3546-03-0- PubChem CID
- 62865
- DTXSID
DTXSID80863190- ChEMBL
CHEMBL2104153- ChEBI
CHEBI:135379- UNII
- A2JGV5CNU4
- EC Number
- 222-594-2
- Nikkaji
- J7.962F
Properties
Computed structural properties
- XLogP
- 4.4
- Topological polar surface area
- 55.6 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 4
- Heavy atoms
- 23
- Formal charge
- 0
- Complexity
- 443
Experimental & physicochemical properties
Human DrugsPharmaceuticals
Melting Point204-205
Physicochemical properties
- Melting point
- 90 · 90-95°C
- Boiling point
- 0.2 · bp0.2-0.5 205-220°
- Density
- 1.21 · 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- 5 mg/mL · DMSO: ≥5mg/mL
- pka
- 9.31 · 9.31±0.28(Predicted)
- form
- powder
- color
- light yellow to yellow-green
- InChI
- 1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
- InChIKey
- SLFGIOIONGJGRT-UHFFFAOYSA-N
- SMILES
- CC(CN(C)C)CN1c2ccccc2Sc3ccc(cc13)C#N
- FDA UNII
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H400 (97.6%): Very toxic to aquatic life [Warning Hazardous to the aquatic environment, acute hazard]
P273, P391, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 42 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory InformationREACH registered substance: Cyamemazine (EC: 222-594-2)
Hazard Classes and CategoriesAquatic Acute 1 (97.6%)
Toxicology
Drug Induced Liver Injury
Drug-Induced Liver Injury Severity and Toxicity (DILIst)
Cyamemazine
DILI Positive
DOI:10.1016/j.drudis.2019.09.022
Safety data
- wgk
- 3
- ridadr
- UN 3077 9 / PGIII
- Toxicity
- LDLo oral in man: 107mg/kg
- risk_code
- 50
- Signal word
- Warning
- Symbol(GHS)
- GHS09
- hazard_code
- Xi,N
- safety_code
- 61
- Storage Class
- 11 - Combustible Solids
Chemistry & industry
Pharmacology
ATC Code
N - Nervous system
QN - Nervous system
Uses & manufacturing
Use ClassificationPharmaceuticals
Applications
UsesCyamemazine is an anxiolytic antipsychotic, which reduces ethanol withdrawal symptoms.
Upstream & downstream products
Upstream raw materials
Suppliers36 total
陕西凯尔凯医药科技有限公司029-2148545164 17392779578 · [email protected]
成都超九八生物科技有限公司13348960310 13348960310 · [email protected]
上海毕得医药科技股份有限公司400-1647117 13681763483 · [email protected]
安耐吉化学&3A（安徽泽升科技有限公司）021-58432009 400-005-6266 · [email protected]
梯希爱（上海）化工贸易有限公司021-61109150 · [email protected]
河南阿尔法化工有限公司0371-55013243 15324716602 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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