Phenylpropanolamine Hydrochloride

HCID 62943

Substructure search Find similar structures

Basic information

CAS: 154-41-6
Standard SMILES: C[C@H](N)[C@H](O)c1ccccc1.Cl
InChIKey: DYWNLSQWJMTVGJ-KUSKTZOESA-N
Molecular formula: C9H13NO.ClH
Average molar mass: 187.66 g/mol
Monoisotopic mass: 187.07639175

Overview

Phenylpropanolamine hydrochloride is an odorless white to creamy-white crystalline powder. Bitter taste. pH (3% solution):4.5-6. pH (10% solution) 4.2-5.5. (NTP, 1992)

Names & identifiers

Preferred name: Phenylpropanolamine Hydrochloride
IUPAC: (1R,2S)-2-amino-1-phenylpropan-1-ol;hydrochloride

Names & synonyms

ObestatPropadrine hydrochlorideHydriatineMucoramaNobeseDecolgenMonydrinPhenylpropanolamine HClPHENYLPROPANOLAMINE HYDROCHLORIDEUNII-8D5I63UE1Q8D5I63UE1Q154-41-6

Show more names

Phenylaminopropanol hydrochlorideNOREPHEDRINE HYDROCHLORIDE(+-)-Norephedrine hydrochlorideEINECS 205-826-7NSC 23798NSC-23798Norephedrine, hydrochlorideDL-1-Phenyl-2-amino-1-propanol monohydrochloride

Database identifiers

CAS: 154-41-6、3198-15-0、53643-20-2
PubChem CID: 62943
DTXSID: DTXSID80891190
ChEMBL: CHEMBL1200695
ChEBI: CHEBI:31996
UNII: 8D5I63UE1Q、B4HG4K9HF5
EC Number: 205-826-7、221-702-5

Properties

Computed structural properties

Topological polar surface area: 46.3 Å²
Hydrogen bond donors: 3
Hydrogen bond acceptors: 2
Rotatable bonds: 2
Heavy atoms: 12
Formal charge: 0
Complexity: 110

Experimental & physicochemical properties

Solubilitygreater than or equal to 100 mg/mL at 70 °F (NTP, 1992)

Human Drugs · 2 items

FDA approved drugs -> Active ingredient

Animal DrugsActive Ingredients (Phenylpropanolamine hydrochloride) -> FDA Greenbook

Melting Point381 to 385 °F (NTP, 1992)

Physical DescriptionPhenylpropanolamine hydrochloride is an odorless white to creamy-white crystalline powder. Bitter taste. pH (3% solution):4.5-6. pH (10% solution) 4.2-5.5. (NTP, 1992)

Safety & regulation

GHS classification

GHS Classification · 6 items

Warning

H302 (92%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 50 reports by companies from 6 notifications to the ECHA C&L Inventory.

Warning

H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]

Hazard information

Regulatory InformationPhenylpropanolamine hydrochloride: Does not have an individual approval but may be used under an appropriate group standard

Other Safety InformationIMAP assessments - Benzenemethanol, .alpha.-(1-aminoethyl)-, hydrochloride, (R*,S*)-(.+-.)-: Human health tier I assessment

DOT LabelPoison

Fire HazardsFlash point data for this chemical are not available; however, it is probably combustible. (NTP, 1992)

Health Hazards · 1 item

SYMPTOMS: Exposure to the compound may cause nausea, nasal dryness, dizziness, headache, nervousness, rapid pulse, sleeplessness and palpitations. It may also cause acute interstitial nephritis, lassitude, restlessness, irritability, aggression, sleep disturbances, psychotic episodes, visual hallucinations, excitability, lack of concentration, paranoid misconceptions, episodic muscular twitchings, tingling feelings in the head, tightness of the chest, rash, tremor and tinnitus. Skin irritation may occur.

Reactive GroupAlcohols and Polyols

Safety & protection

Fire FightingFires involving this material can be controlled with a dry chemical, carbon dioxide or Halon extinguisher. (NTP, 1992)

First Aid · 1 item

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. If symptoms (such as redness or irritation) develop, immediately transport the victim to a hospital.

Nonfire Spill Response · 1 item

SMALL SPILLS AND LEAKAGE: If you spill this chemical, you should dampen the solid spill material with water, then transfer the dampened material to a suitable container. Use absorbent paper dampened with water to pick up any remaining material. Seal your contaminated clothing and the absorbent paper in a vapor-tight plastic bag for eventual disposal. Wash all contaminated surfaces with a soap and water solution. Do not reenter the contaminated area until the Safety Officer (or other responsible person) has verified that the area has been properly cleaned.

Isolation and EvacuationExcerpt from ERG Guide 154 [Substances - Toxic and/or Corrosive (Non-Combustible)]:

Protective Action Criteria (PAC) · 3 items

4.5 [mg/m3]

49 [mg/m3]

300 [mg/m3]

Personal Protective Equipment (PPE) · 1 item

RECOMMENDED RESPIRATOR: Where the neat test chemical is weighed and diluted, wear a NIOSH-approved half face respirator equipped with an organic vapor/acid gas cartridge (specific for organic vapors, HCl, acid gas and SO2) with a dust/mist filter. (NTP, 1992)

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 4 items

Drugs that selectively bind to and activate alpha adrenergic receptors.

Agents that are used to suppress appetite.

Drugs that mimic the effects of stimulating postganglionic adrenergic sympathetic nerves. Included here are drugs that directly stimulate adrenergic receptors and drugs that act indirectly by provoking the release of adrenergic transmitters.

Drugs designed to treat inflammation of the nasal passages, generally the result of an infection (more often than not the common cold) or an allergy related condition, e.g., hay fever. The inflammation involves swelling of the mucous membrane that lines the nasal passages and results in inordinate mucus production. The primary class of nasal decongestants are vasoconstrictor agents. (From PharmAssist, The Family Guide to Health and Medicine, 1993)