Basic information
- CAS
105879-42-3- Standard SMILES
CC1=C(C(=O)O)N2C(=O)[C@@H](NC(=O)[C@H](N)c3ccccc3)[C@H]2SC1.Cl.O- InChIKey
YHJDZIQOCSDIQU-OEDJVVDHSA-N- Molecular formula
- C16H20ClN3O5S
- Average molar mass
- 401.9 g/mol
- Monoisotopic mass
- 401.08121942
Overview
Cephalexin Hydrochloride is the hydrochloride salt form of cephalexin, a beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephalexin hydrochloride binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Names & identifiers
- Preferred name
- Cephalexin Hydrochloride
- IUPAC
- (6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate;hydrochloride
- English name
- Cephalexin monohydrochloride
- Molecular formula
- C16H17N3O4S.ClH.H2O
- Molecular weight
- 401.87
Names & synonyms
Cephalexin hydrochlorideCephalexin HClKeftab105879-42-3Cefalexin hydrochlorideLY0611886VJE5G3D98LY-061188RefChem:57269Cephalexin Monohydrochloride7-(D-2-Amino-2-phenylacetamido)-3-methyl-3-cephem-4-carboxylic acid hydrochloride monohydrateCephalexin (hydrochloride monohydrate)
Show more names
cephalexin hydrochloride monohydrate5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrochloride, monohydrate, (6R,7R)-
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid;hydrate;hydrochlorideCephalexin monohydrochloride monohydrateKeftab (TN)(6R,7R)-7-((2R)-2-Amino-2-phenylacetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, monohydrochloride, monohydrateCephalexin hydrochloride [USAN]UNII-6VJE5G3D98(6R,7R)-7-[(2R)-2-Amino-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monohydrochloride, monohydrateCephalexin hydrochloride [USAN:USP]
Database identifiers
- CAS
105879-42-3- PubChem CID
- 62979
- DTXSID
DTXSID10909777- ChEMBL
CHEMBL1200366- UNII
- 6VJE5G3D98
Properties
Computed structural properties
- Topological polar surface area
- 139 Ų
- Hydrogen bond donors
- 5
- Hydrogen bond acceptors
- 7
- Rotatable bonds
- 4
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 600
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- FDA UNII
- 6 VJE5G3D98 · 6VJE5G3D98
Safety & regulation
Hazard information
Regulatory Information
5-Thia-1-azabicyclo4.2.0oct-2-ene-2-carboxylic acid, 7-(2R)-aminophenylacetylamino-3-methyl-8-oxo-, monohydrochloride, monohydrate, (6R,7R)-: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationSubstances that inhibit the growth or reproduction of BACTERIA.
Applications
UsesAntibacterial.
Suppliers1 total
陕西缔都医药化工有限公司029-81024372 17792795018 · [email protected]
Related reactions
1 records
Compound notes
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