Tert-Butylamine

EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.

This chemical is a combustible liquid. Poisonous gases including nitrogen oxides are produced in fire. Use dry chemical, carbon dioxide, or alcohol foam extinguishers. Vapors are heavier than air and will collect in low areas. Vapors may travel long distances to ignition sources and flashback. Vapors in confined areas may explode when exposed to fire. Containers may explode in fire. Storage containers and parts of containers may rocket great distances, in many directions. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Notify local health and fire officials and pollution control agencies. Containers may explode in fire. From a secure, explosion-proof location, use water spray to cool exposed containers. If cooling streams are ineffective (venting sound increases in volume and pitch, tank discolors, or shows any signs of deforming), withdraw immediately to a secure position. If employees are expected to fight fires, they must be trained and equipped in OSHA 1910.156. /Butyl Amines/

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use "alcohol" foam, dry chemical or carbon dioxide.

Wear self-contained breathing apparatus when fighting fires involving this material.

Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. Contact your Department of Environmental Protection or your regional office of the federal EPA for specific recommendations. If employees are required to clean-up spills, they must be properly trained and equipped. OSHA 1910.120(q) may be applicable. /Butyl Amines/

Small Spills: Use absorbent paper to pick up spilled material. Follow by washing surfaces well with soap and water. Seal all wastes in vapor-tight plastic bags for eventual disposal.

Environmental considerations-land spill: Dig a pit, pond, lagoon, holding area to contain liquid or solid material. /SRP: If time permits, pits, ponds, lagoons, soak holes, or holding areas should be sealed with an impermeable flexible membrane liner./ Dike surface flow using soil, sand bags, foamed polyurethane, or foamed concrete. Absorb bulk liquid with fly ash, cement powder, or commercial sorbents. Apply appropriate foam to diminish vapor and fire hazard. Neutralize with sodium bisulfate (NaHSO4).

Environmental considerations-water spill: Add sodium bisulfate (NaHSO4). If dissolved, in region of 10 ppm or greater concentration, apply activated carbon at ten times the spilled amount. Use mechanical dredges or lifts to remove immobilized masses of pollutants and precipitates.

Environmental considerations-air spill: Apply water spray or mist to knock down vapors.

SRP: The most favorable course of action is to use an alternative chemical product with less inherent propensity for occupational exposure or environmental contamination. Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations.

Controlled incineration; incinerator is equipped with a scrubber or thermal unit to reduce NOx emissions. /Butyl Amines/

Burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device. /n-Butylamine/

/Absorb small spills with paper and/ burn the paper in a suitable location away from combustible materials. Large quantities can be reclaimed or collected & atomized in suitable combustion chamber equipped with appropriate effluent gas cleaning device.

If material not on fire and not involved in fire: Keep sparks, flames, and other sources of ignition away. Keep material out of water sources and sewers. Build dikes to contain flow as necessary. Attempt to stop leak if without undue personnel hazard. Use water spray to disperse vapors and dilute standing pools of liquid.

SRP: The scientific literature for the use of contact lenses in industry is conflicting. The benefit or detrimental effects of wearing contact lenses depend not only upon the substance, but also on factors including the form of the substance, characteristics and duration of the exposure, the uses of other eye protection equipment, and the hygiene of the lenses. However, there may be individual substances whose irritating or corrosive properties are such that the wearing of contact lenses would be harmful to the eye. In those specific cases, contact lenses should not be worn. In any event, the usual eye protection equipment should be worn even when contact lenses are in place.

Personnel protection: Avoid breathing vapors. Keep upwind. Avoid bodily contact with the material. ... Do not handle broken packages unless wearing appropriate personal protective equipment. Wash away any material which may have contacted the body with copious amounts of water or soap and water. ... If contact with the material anticipated, wear appropriate chemical protective clothing.

1.4 [mg/m3]

15 [mg/m3]

170 [mg/m3]

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 0.40(2) and a regression-derived equation(3), indicates that tert-butylamine is expected to have very high mobility in soil(SRC). The pKa of tert-butylamine is 10.68(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5). Volatilization of tert-butylamine from moist soil surfaces is not expected to be an important fate process(SRC) given its cation state(SRC). tert-Butylamine is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(6). tert-Butylamine was biodegraded by aniline-acclimated activated sludge(7).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 40(SRC), determined from a log Kow of 0.40(2) and a regression-derived equation(3), indicates that tert-butylamine is not expected to adsorb to suspended solids and sediment(SRC). A pKa of 10.68(4) indicates tert-butylamine will exist almost entirely in the cation form at pH values of 5 to 9 and therefore volatilization from water surfaces is not expected to be an important fate process(5). According to a classification scheme(6), an estimated BCF of 3(SRC), from its log Kow(2) and a regression-derived equation(7), suggests the potential for bioconcentration in aquatic organisms is low(SRC). tert-Butylamine was biodegraded by aniline-acclimated activated sludge(8).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tert-butylamine, which has a vapor pressure of 372 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tert-butylamine is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 33 hours(SRC), calculated from its rate constant of 1.18X10-11 cu cm/molecule-sec at 25 °C(3). tert-Butylamine does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

/AQUATIC SPECIES/ The toxicity of amines to aquatic animals (Selenastrum capricornutum /Freshwater algae/ , Daphnia magna /Daphnid/, and Salmo gairdneri /Rainbow trout/) depended on their structure and was species-dependent. ... The integrated rating system (Canton and Sloof, 1979) was used for evaluation of the environmental hazard of these amines.

The Koc of tert-butylamine is estimated as 40(SRC), using a log Kow of 0.40(1) and a regression-derived equation(2). According to a classification scheme(3), this estimated Koc value suggests that tert-butylamine is expected to have very high mobility in soil. The pKa of tert-butylamine is 10.68(4), indicating that this compound will exist almost entirely in the cation form in the environment and cations generally adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(5).

... amines from decomposing fish ... /Amines/

tert-Butylamine has been found to occur naturally in Latakia tobacco leaves(1).

/SIGNS AND SYMPTOMS/ Exposure to tertiary amines has been associated with a number of visual disturbances, including inability to focus and halovision. These result from edema (swelling) of the cornea (the clear, front part of the eye). In addition, a number of systemic effects have been reported, including tachycardia (rapid heart beat) and a transient drop in blood pressure.

/SIGNS AND SYMPTOMS/ ... Skin irritant.

/SIGNS AND SYMPTOMS/ May cause pulmonary edema.

/SIGNS AND SYMPTOMS/ Irritation of eyes, nose, skin, and mucous membranes.

/OTHER TOXICITY INFORMATION/ Amines ... may form strongly alkaline solutions, they can be damaging if splashed in the eye or if allowed to contaminate the skin. /Amines, aliphatic/

Volatile amines, incl tert-butylamine, were present (about 0.8% of the total organic carbon) in a municipal waste dump at the acidification stage (as opposed to the methane fermentation stage) in the Netherlands.

tert-Butylamine's production and use as an intermediate for rubber accelerators, insecticides, fungicides, dyestuffs, and pharmaceuticals(1) may result in its release to the environment through various waste streams(SRC).

AEROBIC: No biodegradation of tert-butylamine (10-100 ppm) was observed over a 12-day incubation period using Sapromat respiration assays with river mud bacteria inocula, treatment plant sludge inocula, or adapted bacteria inocula(1). tert-Butylamine was biodegraded by aniline-acclimated activated sludge using a Warburg respirometer(2). The bacteria Alcaligenes faecalis, isolated from activated sludge, was not able to biodegrade tert-butylamine using the Warburg technique(3).

An estimated BCF of 3 was calculated in fish for tert-butylamine(SRC), using a log Kow of 0.40(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low(SRC).

This action promulgates standards of performance for equipment leaks of Volatile Organic Compounds (VOC) in the Synthetic Organic Chemical Manufacturing Industry (SOCMI). The intended effect of these standards is to require all newly constructed, modified, and reconstructed SOCMI process units to use the best demonstrated system of continuous emission reduction for equipment leaks of VOC, considering costs, non air quality health and environmental impact and energy requirements. Tert-butylamine is produced, as an intermediate or a final product, by process units covered under this subpart.

Persons in charge of vessels or facilities are required to notify the National Response Center (NRC) immediately, when there is a release of this designated hazardous substance, in an amount equal to or greater than its reportable quantity of 1000 lb or 454 kg. The toll free number of the NRC is (800) 424-8802. The rule for determining when notification is required is stated in 40 CFR 302.4 (section IV. D.3.b). [checked 5/2006]

tert-Butylamine is designated as a hazardous substance under section 311(b)(2)(A) of the Federal Water Pollution Control Act and further regulated by the Clean Water Act Amendments of 1977 and 1978. These regulations apply to discharges of this substance. This designation includes any isomers and hydrates, as well as any solutions and mixtures containing this substance.