Tetramethylsilane

HCID 6396CAS 75-76-3

Basic information

Standard SMILES
C[Si](C)(C)C
InChIKey
CZDYPVPMEAXLPK-UHFFFAOYSA-N
Molecular formula
C4H12Si
Average molar mass
88.22 g/mol
Monoisotopic mass
88.07082692

Names & identifiers

Preferred name
Tetramethylsilane
IUPAC
tetramethylsilane
English name
Tetramethylsilane
Molecular formula
C4H12Si
Molecular weight
88.22

Names & synonyms

TETRAMETHYLSILANE75-76-3Silane, tetramethyl-Tetramethyl silaneTetramethylsilicane41Y0RBG14QDTXSID9026423NSC-5210DTXCID206423CHEBI:85361Silicon tetramethylRefChem:188793
Show more names
TMS4MS(CH3)4SiSi(CH3)4TrialkylsilaneTetraMethylsilane, ACS reagent, NMR gradeCT2050DKSI045
200-899-1Silicon, tetramethyl-NSC 5210Tetramethyl-silaneEINECS 200-899-1UNII-41Y0RBG14QMFCD00008274UN2749

Database identifiers

CAS
75-76-3
PubChem CID
6396
DTXSID
DTXSID9026423
ChEMBL
CHEMBL68073
ChEBI
CHEBI:85361
UNII
41Y0RBG14Q
EC Number
200-899-1
Nikkaji
J2.258.481B、J35.910F

Properties

Computed structural properties

Topological polar surface area
0 Ų
Hydrogen bond donors
0
Hydrogen bond acceptors
0
Rotatable bonds
0
Heavy atoms
5

Experimental & physicochemical properties

LogPlog Kow = 3.24
Density · 2 items

0.641 g/cu cm at 25 °C

0.648 @25 °C

Color/FormVolatile liquid or gas
Solubility · 3 items

Insoluble in cold concentrated sulfuric acid; soluble in most organic solvents

Very soluble in ethanol and ether

In water, 19.6 mg/L at 25 °C

Flash Point-27 dec C (closed cup)
Boiling Point26.6 °C

Physicochemical properties

Melting point
-99 °C · -99 °C (lit.)
Boiling point
26 · 26-28 °C (lit.)
Density
0.648 g/mL · 0.648 g/mL at 25 °C (lit.)
vapor pressure
11.66 psi · 11.66 psi ( 20 °C)
refractive index
20 · n20/D 1.358(lit.)
RTECS
5706000 · VV5706000

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H224 (99.2%): Extremely flammable liquid and vapor [Danger Flammable liquids];H302 (17.3%): Harmful if swallowed [Warning Acute toxicity, oral];H411 (23.6%): Toxic to aquatic life with long lasting effects [Hazardous to the aquatic environment, long-term hazard]

P210, P233, P240, P241, P242, P243, P264, P270, P273, P280, P301+P317, P303+P361+P353, P330, P370+P378, P391, P403+P235, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 127 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

Hazard information

Regulatory Information · 5 items

Chemical: Silane, tetramethyl-

Silane, tetramethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Silane, tetramethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14468

Tetramethylsilane: HSNO Approval: HSR005569 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DOT LabelFlammable Liquid
Fire Hazards · 2 items

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:;HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.). Vapor explosion hazard indoors, outdoors or in sewers. Those substances designated with a (P) may polymerize explosively when heated or involved in a fire. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids will float on water. (ERG, 2024)

· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.;· Vapors may form explosive mixtures with air.;· Vapors may travel to source of ignition and flash back.;· Most vapors are heavier than air. They will spread along the ground and collect in low or confined areas (sewers, basements, tanks, etc.).;· Vapor explosion hazard indoors, outdoors or in sewers.;· Those substances designated with a (P) may polymerize explosively when heated or involved in a fire.;· Runoff to sewer may create fire or explosion hazard.;· Containers may explode when heated.;· Many liquids will float on water.

Fire Potential · 2 items

A very dangerous fire hazard when exposed to heat or flame. Spontaneously flammable in air.

Tetramethylsilicane is spontaneously flammable in air. /Tetramethylsilicane/

Health Hazards · 2 items

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:;May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas. Runoff from fire control or dilution water may cause environmental contamination. (ERG, 2024)

· May cause toxic effects if inhaled or absorbed through skin.;· Inhalation or contact with material may irritate or burn skin and eyes.;· Fire will produce irritating, corrosive and/or toxic gases.;· Vapors may cause dizziness or asphyxiation, especially when in closed or confined areas.;· Runoff from fire control or dilution water may cause environmental contamination.

Hazards Summary · 1 item

Pyrophoric; No adverse effects observed in combined subchronic/reproductive/developmental inhalation study of rats at concentrations up to 5,000 ppm/6 hours/day; [HSDB] A mild irritant; Inhalation of vapor may cause nose, throat, and lung irritation and pose an asphyxiation hazard; Harmful by ingestion; [Air Products MSDS] See Diethylsilane.

Safety & protection

Fire Fighting · 1 item

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:;CAUTION: The majority of these products have a very low flash point. Use of water spray when fighting fire may be inefficient.;SMALL FIRE: Dry chemical, CO2, water spray or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam.;LARGE FIRE: Water spray, fog or regular foam. If regular foam is ineffective or unavailable, use alcohol-resistant foam. Avoid aiming straight or solid streams directly onto the product. If it can be done safely, move undamaged containers away from the area around the fire.;FIRE INVOLVING TANKS, RAIL TANK CARS OR HIGHWAY TANKS: Fight fire from maximum distance or use unmanned master stream devices or monitor nozzles. Cool containers with flooding quantities of water until well after fire is out. Withdraw immediately in case of rising sound from venting safety devices or discoloration of tank. ALWAYS stay away from tanks in direct contact with flames. For massive fire, use unmanned master stream devices or monitor nozzles; if this is impossible, withdraw from area and let fire burn. (ERG, 2024)

Accidental Release Measures · 2 items

· CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.;· Keep unauthorized personnel away.;· Stay upwind, uphill and/or upstream.;· Ventilate closed spaces before entering, but only if properly trained and equipped.

· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area.;· All equipment used when handling the product must be grounded.;· Do not touch or walk through spilled material.;· Stop leak if you can do it without risk.;· Prevent entry into waterways, sewers, basements or confined areas.;· A vapor-suppressing foam may be used to reduce vapors.;· Absorb or cover with dry earth, sand or other non-combustible material and transfer to containers.;· Use clean, non-sparking tools to collect absorbed material.;Large Spill;· Dike far ahead of liquid spill for later disposal.;· Water spray may reduce vapor, but may not prevent ignition in closed spaces.

First Aid · 2 items

Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)]:;Refer to the "General First Aid" section. Specific First Aid: Wash skin with soap and water. In case of burns, immediately cool affected skin for as long as possible with cold water. Do not remove clothing if adhering to skin. (ERG, 2024)

General First Aid:;· Call 911 or emergency medical service.;· Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and avoid contamination.;· Move victim to fresh air if it can be done safely.;· Administer oxygen if breathing is difficult.;· If victim is not breathing:;-- DO NOT perform mouth-to-mouth resuscitation; the victim may have ingested or inhaled the substance.;-- If equipped and pulse detected, wash face and mouth, then give artificial respiration using a proper respiratory medical device (bag-valve mask, pocket mask equipped with a one-way valve or other device).;-- If no pulse detected or no respiratory medical device available, provide continuous compressions. Conduct a pulse check every two minutes or monitor for any signs of spontaneous respirations.;· Remove and isolate contaminated clothing and shoes.;· For minor skin contact, avoid spreading material on unaffected skin.;· In case of contact with substance, remove immediately by flushing skin or eyes with running water for at least 20 minutes.;· For severe burns, immediate medical attention is required.;· Effects of exposure (inhalation, ingestion, or skin contact) to substance may be delayed.;· Keep victim calm and warm.;· Keep victim under observation.;· For further assistance, contact your local Poison Control Center.;· Note: Basic Life Support (BLS) and Advanced Life Support (ALS) should be done by trained professionals.;Specific First Aid:;· Wash skin with soap and water.

Exposure Control and Personal Protection· Wear positive pressure self-contained breathing apparatus (SCBA).;· Structural firefighters' protective clothing provides thermal protection but only limited chemical protection.
Fire Fighting Procedures · 4 items

If material on fire or involved in fire: Do not extinguish fire unless flow can be stopped. Use water in flooding quantities as fog. Solid streams of water may spread fire. Cool all affected containers with flooding quantities of water. Apply water from as far a distance as possible. Use foam, dry chemical, or carbon dioxide.

Wear positive pressure self-contained breathing apparatus when fighting fires involving this material.

Suitable extinguishing media: For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water. ... Use water spray to cool unopened containers.

Special protective equipment for fire-fighters: Wear self contained breathing apparatus for fire fighting if necessary.

Storage Conditions · 1 item

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage. Recommended storage temperature: 2 - 8 °C Over time, pressure may increase causing containers to burst. Handle and open container with care.

Toxicology

Body Burden · 1 item

Samples collected and analyzed during the period from July to December 1980 detected tetramethylsilane on 4 of 12 subjects' exhaled breath in Bayonne and Elizabeth, New Jersey (nine subjects) and Research Triangle Park, North Carolina (3 subjects). The subjects were workers in the chemical and oil industries as well as a sewage treatment plant worker(1).

Environmental Fate · 3 items

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 44(SRC), determined from a structure estimation method(2), indicates that tetramethylsilane is expected to have very high mobility in soil(SRC). Volatilization of tetramethylsilane from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 4.25 atm-cu m/mole(SRC), based upon its vapor pressure, 718 mm Hg(3), and water solubility, 19.6 mg/L(4). Tetramethylsilane is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure(3). Biodegradation data were not available(SRC, 2009).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 44(SRC), determined from a structure estimation method(2), indicates that tetramethylsilane is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 4.25 atm-cu m/mole(SRC), derived from its vapor pressure, 718 mm Hg(4), and water solubility, 19.6 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.7 hours and 3.7 days, respectively(SRC). According to a classification scheme(6), an estimated BCF of 64(SRC), from a log Kow of 3.24(7) and a regression-derived equation(8), suggests the potential for bioconcentration in aquatic organisms is moderate(SRC). Biodegradation data were not available(SRC, 2009).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), tetramethylsilane, which has a vapor pressure of 718 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase tetramethylsilane is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 16 days(SRC), calculated from its rate constant of 1.00X10-12 cu cm/molecule-sec at 25 °C(3). Tetramethylsilane does not contain chromophores that absorb at wavelengths >290 nm(4) and therefore is not expected to be susceptible to direct photolysis by sunlight(SRC).

Adverse EffectsOther Poison - Simple Asphyxiant
Soil Adsorption/Mobility · 1 item

Using a structure estimation method based on molecular connectivity indices(1), the Koc of tetramethylsilane can be estimated to be 44(SRC). According to a classification scheme(2), this estimated Koc value suggests that tetramethylsilane is expected to have very high mobility in soil.

Artificial Pollution Sources · 1 item

Tetramethylsilane's production and use in chemical deposition of films of silicon carbide, as a 1H NMR primary reference standard(1), and as an additive to aviation fuel(2) may result in its release to the environment through various waste streams(SRC).

Environmental Bioconcentration · 1 item

An estimated BCF of 64 was calculated for tetramethylsilane(SRC), using a log Kow of 3.24(1) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is moderate(SRC), provided the compound is not metabolized by the organism(SRC).

Regulatory information

Regulatory Information · 5 items

Chemical: Silane, tetramethyl-

Silane, tetramethyl- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Silane, tetramethyl- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 13-10-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/14468

Tetramethylsilane: HSNO Approval: HSR005569 Approved with controls

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

DHS Chemicals of Interest (COI) · 4 items

Tetramethylsilane

1

10000

Flammable chemical that can be released at a facility.

Safety data

F
10
wgk
3
tsca
TSCA listed
ridadr
UN 2749
hs_code
2931 90 00
risk_code
12-48/20/22-40-38-22

Chemistry & industry

Uses & manufacturing

Uses · 4 items

Used as NMR reference standard, in semiconductor chemical vapor deposition, and for silylation of samples for GC analysis; [Merck Index] Used as an aviation fuel; [CAMEO] Used in semiconductor processing; [Air Products MSDS]

Semiconductor Manufacturing [Category: Industry]

In aviation fuel

Used in chemical deposition of films of silicon carbide; 1H NMR primary reference standard

U.S. Production · 4 items

2023: 1,000,000 - <2,500,000 lb;2022: 1,000,000 - <2,500,000 lb;2021: 1,000,000 - <2,500,000 lb;2020: 1,000,000 - <2,500,000 lb

Silane, tetramethyl- is listed as a High Production Volume (HPV) chemical (65FR81686). Chemicals listed as HPV were produced in or imported into the U.S. in >1 million pounds in 1990 and/or 1994. The HPV list is based on the 1990 Inventory Update Rule. (IUR) (40 CFR part 710 subpart B; 51FR21438).

Production volumes for non-confidential chemicals reported under the Inventory Update Rule. [Table#7428]

Production volume for non-confidential chemicals reported under the 2006 Inventory Update Rule. Chemical: Silane, tetramethyl-. Aggreated National Production Volume: 1 to < 10 million lbs.

Industry UsesPlating agent;Intermediate
Methods of ManufacturingBy Grignard reaction of silicon tetrachloride and methylmagnesium chloride.
General Manufacturing Information · 2 items

All Other Basic Organic Chemical Manufacturing;All Other Chemical Product and Preparation Manufacturing;Electrical Equipment, Appliance, and Component Manufacturing;All Other Basic Inorganic Chemical Manufacturing

Silane, tetramethyl-: ACTIVE

Applications · 3 items

UsesTetramethylsilane is used as a building block in organometallic chemistry. It acts as a by-product in the production of methyl chlorosilanes. Also, it serves as a precursor to silicon dioxide or silicon carbide. It is used as internal reference standard for the calibration of chemical sift for 1, 13 and 29 NMR spectroscopy. In addition, it is used as an aviation fuel.

UsesNMR reference standard. In semiconductor applications (chemical vapor deposition). Tetramethylsilane (TMS) is used as a chemical shift reference for proton, carbon-13, and silicon-29 analysis in organic solvents and is given 0 as its chemical shift position.

General DescriptionTetramethylsilane appears as a colorless, mildly acidic volatile liquid. A serious fire hazard. Mildly toxic by ingestion. Emits acrid smoke and fumes when heated to high temperatures. Less dense than water and insoluble in water, but soluble in most organic solvents. Used as an aviation fuel and as an internal standard for nmr analytical instruments.

Preparation methods · 1 item

PreparationAt present, the synthesis method of Tetramethylsilane mainly comprises two methods, namely, tetrachlorosilane or tetraethoxysilane is reacted with methyl magnesium iodide to prepare the tetramethylsilane. The second one is prepared by reacting chloromethane and silicon powder in the presence of copper catalyst and then carrying out fine fractionation.

Suppliers50 total

国药集团化学试剂有限公司86-21-63210123 · [email protected]
梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]
上海源象化学有限公司17312431727 · [email protected]
安徽旺山旺水特种气体有限公司15906197626 · [email protected]
上海比阳实业有限公司+86-21-52699951; +8613917686115 · [email protected]

Additional notes

DefinitionChEBI: Tetramethylsilane is an organosilicon compound that is silane in which the hydrogens have been replaced by methyl groups.

Related reactions

4 records

Linked notes

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