Sulfacetamide Sodium
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Basic information
- CAS
127-56-0- Standard SMILES
CC(=O)[N-]S(=O)(=O)c1ccc(N)cc1.O.[Na+]- InChIKey
IHCDKJZZFOUARO-UHFFFAOYSA-M- Molecular formula
- C8H11N2NaO4S
- Average molar mass
- 254.24 g/mol
- Monoisotopic mass
- 254.03372229
Overview
Sulfacetamide sodium is an organic sodium salt that is the monohydrate form of sulfacetamide sodium. It has a role as an antimicrobial agent, an antiinfective agent and an EC 2.5.1.15 (dihydropteroate synthase) inhibitor. It is a hydrate and an organic sodium salt. It contains a member of sulfacetamide sodium anhydrous.
Names & identifiers
- Preferred name
- Sulfacetamide Sodium
- IUPAC
- sodium;acetyl-(4-aminophenyl)sulfonylazanide;hydrate
- English name
- Sulfacetamide sodium
- Molecular formula
- C8H13N2NaO4S
- Molecular weight
- 256.25
Names & synonyms
6209-17-2Sulfacetamide sodium monohydrateSodium sulamydKlaronBlephSulfacetamide sodium salt monohydrateOcusulfSulfacelSodium N-sulfanilylacetamide monohydrateSulfair ForteSulfacel-15Ocusulf-10
Show more names
SA-NaBIO-FARMA BF003142SufacetaMide sodiuMSuffacetamide sodiumSulfacetamide sodiumSodium sufacetamide USPsulfacetamide sodium， SASulfacetamideSodiumEyeDropsSODIUM SULFACETAMIDE HYDRATESulfacetamide Sodium (500 mg)
Sulfair 10Sulfair-15Isopto cetamideSulten-10Sulfacetamidum natricumSulf-15OCUSULF-30BLEPH-30
Database identifiers
- CAS
127-56-0、6209-17-2
Properties
Computed structural propertiesFilling in
- Topological polar surface area
- 87.6 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 2
- Heavy atoms
- 16
- Formal charge
- 0
- Complexity
- 304
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Physicochemical properties
- Melting point
- 263 · 263-265°C
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- 2 O: · H2O: soluble50mg/mL
- form
- powder
- color
- white to off-white
- Water Solubility
- Freely soluble in water. Insoluble in chloroform, ether, and benzene.
- Major Application
- pharmaceutical (small molecule)
- InChI
- 1S/C8H10N2O3S.Na.H2O/c1-6(11)10-14(12,13)8-4-2-7(9)3-5-8;;/h2-5H,9H2,1H3,(H,10,11);;1H2/q;+1;/p-1
- InChIKey
- IHCDKJZZFOUARO-UHFFFAOYSA-M
- SMILES
- NC1=CC=C(S(N([Na])C(C)=O)(=O)=O)C=C1.O
- CAS DataBase Reference
- 6209 · 6209-17-2
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 4.5% (2 of 44) of reports.
Warning
H315 (93.2%): Causes skin irritation [Warning Skin corrosion/irritation]
P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 44 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
This chemical does not meet GHS hazard criteria for 16.7% (1 of 6) of reports.
Hazard information
Other Safety InformationIMAP assessments - Acetamide, N-[(4-aminophenyl)sulfonyl]-, monosodium salt, monohydrate: Environment tier I assessment
Hazard Classes and Categories
Skin Irrit. 2 (93.2%)
Skin Sens. 1 (16.7%)
Safety data
- wgk
- 3
- rtecs
- AC8480000
- hs_code
- 29350090
- risk_code
- 36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 26-36-37
- Storage Class
- 11 - Combustible Solids
- Hazard statements
- H315-H319-H335
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
SULFACETAMIDE SODIUM
Sulfonamide Antibacterial [EPC]; Sulfonamides [CS]
MeSH Pharmacological Classification
Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects.
Substances capable of killing agents causing urinary tract infections or of preventing them from spreading.
Substances that inhibit the growth or reproduction of BACTERIA.
Applications
UsesSulfacetamide sodium salt hydrate is an anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections. It adapts to cure trachoma, conjunctivitis, keratitis.
UsesAntibacterial;Inhibitor of folic acid synthesis
General DescriptionN-Sulfanilylacetamide monosodium salt (Sodium Sulamyd)is obtained as the monohydrate and is a white, odorless, bitter,crystalline powder that is very soluble (1:2.5) in water.Because the sodium salt is highly soluble at the physiologicalpH of 7.4, it is especially suited, as a solution, forrepeated topical applications in the local management ofophthalmic infections susceptible to sulfonamide therapy.
Additional notes
DefinitionChEBI: Sulfacetamide sodium is an organic sodium salt that is the monohydrate form of sulfacetamide sodium. It has a role as an antimicrobial agent, an antiinfective agent and an EC 2.5.1.15 (dihydropteroate synthase) inhibitor. It is an organic sodium salt and a hydrate. It contains a member of sulfacetamide sodium anhydrous.
Related reactions
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Compound notes
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