1,1,1-Tribromo-2-methyl-2-propanol

Danger

H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P332+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 38 reports by companies from 1 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 7(SRC), determined from a structure estimation method(2), indicates that 1,1,1-tribromo-2-methyl-2-propanol is expected to have very high mobility in soil(SRC). Volatilization of 1,1,1-tribromo-2-methyl-2-propanol from moist soil surfaces is not expected to be an important fate process(SRC) given an estimated Henry's Law constant of 9.6X10-9 atm-cu m/mole(SRC), obtained using a fragment constant estimation method(3). 1,1,1-Tribromo-2-methyl-2-propanol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.001 mm Hg(SRC), determined from a fragment constant method(4). The importance of biodegradation of 1,1,1-tribromo-2-methyl-2-propanol in soil is not known(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 7(SRC), determined from a structure estimation method(2), indicates that 1,1,1-tribromo-2-methyl-2-propanol is not expected to adsorb to suspended solids and sediment in water(SRC). Volatilization from water surfaces is not expected(3) based upon an estimated Henry's Law constant of 9.6X10-9 atm-cu m/mole(SRC), developed using a fragment constant estimation method(4). According to a classification scheme(5), an estimated BCF of 13(3,SRC), from an estimated log Kow(6,SRC), suggests the potential for bioconcentration in aquatic organisms is low(SRC). The importance of biodegradation of 1,1,1-tribromo-2-methyl-2-propanol in water is not known(SRC).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), 1,1,1-tribromo-2-methyl-2-propanol, which has an estimated vapor pressure of 0.001 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,1,1-tribromo-2-methyl-2-propanol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 14 days(SRC) from its estimated rate constant of 1.17X10-12 atm cu m/mol(3).

Using a structure estimation method based on molecular connectivity indices(1), the Koc for 1,1,1-tribromo-2-methyl-2-propanol can be estimated to be about 7(SRC). According to a classification scheme(2), this estimated Koc value suggests that 1,1,1-tribromo-2-methyl-2-propanol is expected to have very high mobility in soil.

An estimated BCF of 13 was calculated for 1,1,1-tribromo-2-methyl-2-propanol(SRC), using an estimated log Kow of 2.35(1,SRC) and a regression-derived equation(2). According to a classification scheme(3), this BCF suggests the potential for bioconcentration in aquatic organisms is low.

The Henry's Law constant for 1,1,1-tribromo-2-methyl-2-propanol is estimated as 9.6X10-9 atm-cu m/mole(SRC) using a fragment constant estimation method(1). This Henry's Law constant indicates that 1,1,1-tribromo-2-methyl-2-propanol is expected to be essentially nonvolatile(2). Based on this Henry's Law constant, the volatilization half-life from a model river (1 m deep, flowing 1 m/sec, wind velocity of 3 m/sec)(2) is estimated as >6,000 days(SRC). The volatilization half-life from a model lake (1 m deep, flowing 0.05 m/sec, wind velocity of 0.5 m/sec)(2) is estimated as >50,000 days(SRC). 1,1,1-Tribromo-2-methyl-2-propanol's Henry's Law constant(1) indicates that volatilization from moist soil surfaces is not expected to occur(SRC). 1,1,1-Tribromo-2-methyl-2-propanol is not expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.001 mm Hg(3) determined from a fragment constant method(3).

The rate constant for the vapor-phase reaction of 1,1,1-tribromo-2-methyl-2-propanol with photochemically-produced hydroxyl radicals has been estimated as 1.17X10-12 cu cm/molecule-sec at 25 °C(SRC) using a structure estimation method(1). This corresponds to an atmospheric half-life of about 14 days at an atmospheric concentration of 5X10+5 hydroxyl radicals per cu cm(1). 1,1,1-Tribromo-2-methyl-2-propanol is not expected to directly photolyze due to the lack of absorption in the environmental spectrum(2).

1,1,1-Tribromo-2-methyl-2-propanol's production and use as a modifier in the polymerization of vinyl chloride may result in its release to the environment through various waste streams. If released to air, an estimated vapor pressure of 0.001 mm Hg at 25 °C indicates 1,1,1-tribromo-2-methyl-2-propanol will exist solely as a vapor in the ambient atmosphere. Vapor-phase 1,1,1-tribromo-2-methyl-2-propanol will be degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals; the half-life for this reaction in air is estimated to be 14 days. If released to soil, l,1,1-tribromo-2-methyl-2-propanol is expected to have very high mobility based upon an estimated Koc of 7. The importance of biodegradation of 1,1,1-tribromo-2-methyl-2-propanol in soil and water is not known. Volatilization from moist soil surfaces is not expected to be an important fate process based upon an estimated Henry's Law constant of 9.6X10-9 atm-cu m/mole. If released into water, 1,1,1-tribromo-2-methyl-2-propanol is not expected to adsorb to suspended solids and sediment in the water column based upon the estimated Koc. Volatilization from water surfaces is not expected to be an important fate process based upon this compound's estimated Henry's Law constant. An estimated BCF of 13 suggests the potential for bioconcentration in aquatic organisms is low. Occupational exposure to 1,1,1-tribromo-2-methyl-2-propanol may occur through inhalation and dermal contact with this compound at workplaces where 1,1,1-tribromo-2-methyl-2-propanol is produced or used. (SRC)

Used as modifier in polymerization of vinyl chloride and in other organic synthesis; [HSDB]

AS MODIFIER IN POLYMERIZATION OF VINYL CHLORIDE

Organic synthesis