11104-61-3[Co+2].[Co+3].[Co+3].[O-2].[O-2].[O-2].[O-2]UBEWDCMIDFGDOO-UHFFFAOYSA-N11104-61-3、1308-06-1Large Crystals; Dry Powder
Black or grey solid; [Merck Index] Black powder, insoluble in water; [MSDSonline]
This chemical does not meet GHS hazard criteria for 100% (7 of 7) of all reports.
Not Classified;Reported as not meeting GHS hazard criteria by 7 of 7 companies. For more detailed information, please visit ECHA C&L website.
Aggregated GHS information provided per 7 reports by companies from 1 notifications to the ECHA C&L Inventory.;Reported as not meeting GHS hazard criteria per 7 of 7 reports by companies.;There are 0 notifications provided by 0 of 7 reports by companies with hazard statement code(s).;Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.
Danger
H317: May cause an allergic skin reaction [Warning Sensitization, Skin];H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled [Danger Sensitization, respiratory];H372: Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
Chemical: Cobalt oxide
Cobalt oxide is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cobalt oxide are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 21-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15110
Cobalt oxide: Does not have an individual approval but may be used under an appropriate group standard
Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)
Used in enamels, semiconductors, and grinding wheels; [Merck Index] When cobalt (II) oxide is heated at 400-500 deg C in an atmosphere of oxygen, the cobalt (II,III) oxide is formed. [Ullmann]
Semiconductor Manufacturing [Category: Industry]
Enameling [Category: Hobbies]
No data.
Petroleum Refineries;Primary Metal Manufacturing
Cobalt oxide: ACTIVE
UsesCobalt oxide is used in the manufacture of paint pigments, ceramic glazes, and cobalt catalysts, etc.
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Not Classified
Specific target organ toxicity (repeated exposure) - category 1;Reproductive toxicity - category 1B;Respiratory sensitisation - category 1;Skin sensitisation - category 1;Acute toxicity (ingestion) - category 3;Acute toxicity (inhalation) - category 2
Respiratory sensitization - Category 1A;Skin sensitization - Category 1A;Specific target organ toxicity - Repeated exposure - Category 1 (respiratory organs)
0.082 [mg/m3]
6.7 [mg/m3]
40 [mg/m3]
Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29)
Chemical: Cobalt oxide
Cobalt oxide is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Cobalt oxide are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
Status: Active Update: 21-04-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15110
Cobalt oxide: Does not have an individual approval but may be used under an appropriate group standard