Amlodipine Maleate

HCID 6435922
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Basic information

CAS
88150-47-4
Standard SMILES
CCOC(=O)C1=C(COCCN)NC(C)=C(C(=O)OC)C1c1ccccc1Cl.O=C(O)/C=C\C(=O)O
InChIKey
TZNOWAJJWCGILX-BTJKTKAUSA-N
Molecular formula
C24H29ClN2O9
Average molar mass
524.9 g/mol
Monoisotopic mass
524.15615819

Overview

Amlodipine Maleate is the maleate salt of amlodipine, a synthetic phenylpyridine vasodilator with antihypertensive and antianginal effects. Amlodipine inhibits the influx of extracellular calcium ions into myocardial and peripheral vascular smooth muscle cells, thereby preventing vascular and myocardial contraction. Furthermore, decreased myocardial contractility and dilation of the main coronary and systemic arteries lead to increased blood flow and oxygen delivery to the myocardial tissue and decreases total peripheral resistance. This agent may also modulate multi-drug resistance (MDR) activity through inhibition of the p-glycoprotein efflux pump.

Names & identifiers

Preferred name
Amlodipine Maleate
IUPAC
(Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
English name
Amlodipine maleate
Molecular formula
C30H35ClN2O12S
Molecular weight
524.95

Names & synonyms

Amlodipine maleate88150-47-4AmvazCQ27G2BZJMUK-48,340-11UK-48340-11DTXSID601027708RefChem:54171DTXCID901513285Amlodipine (maleate)Amlodipine maleate [USAN]3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate maleate
Show more names
Amlodipine IH Impurity AAmlodipine maleate USP/EP/BPAmlodipine maleate - Bio-X ?AMLODIPINE MALEATE MM STANDARDAmlodipine maleate (crystalline)Amlodipine maleate, 10 mM in DMSOAmlodipineMaleateC20H25C1N205.C4H4043-Ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5
UNII-CQ27G2BZJMMFCD02259457(Z)-but-2-enedioic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate1357024-06-6Amlodipine maleate (USAN)C24H29ClN2O9Amlodipine (+-)-form maleateUK 48,340-11

Database identifiers

CAS
88150-47-4
PubChem CID
6435922
DTXSID
DTXSID601027708
ChEMBL
CHEMBL1200984
UNII
CQ27G2BZJM
EC Number
629-849-0

Properties

Computed structural properties

Topological polar surface area
174 Ų
Hydrogen bond donors
4
Hydrogen bond acceptors
11
Rotatable bonds
12
Heavy atoms
36

Experimental & physicochemical properties

Human Drugs · 2 items

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

Physicochemical properties

Melting point
178 · 178-179°
storage temp.
Sealed in dry,Room Temperature
solubility
DMSO (Slightly), Methanol (Slightly)
form
Solid
color
Off-White to Pale Yellow
Stability
Light Sensitive

Safety & regulation

GHS classification

GHS Classification · 4 items

Danger

H301 (40%): Toxic if swallowed [Danger Acute toxicity, oral]

P203, P261, P262, P264, P264+P265, P270, P271, P273, P280, P301+P316, P301+P317, P302+P352, P304+P340, P305+P351+P338, P305+P354+P338, P316, P317, P318, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P391, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 5 reports by companies from 5 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Hazard information

Hazard Classes and CategoriesAcute Tox. 3 (40%)

Safety data

Signal word
Warning
Symbol(GHS)
GHS07
Hazard statements
H302-H315-H319-H335
Precautionary statements
P261-P305+P351+P338

Chemistry & industry

Pharmacology

MeSH Pharmacological Classification · 3 items

Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.

A class of drugs that act by selective inhibition of calcium influx through cellular membranes.

Drugs used to cause dilation of the blood vessels.

Applications

UsesAnti-anginal; antihypertensive.

Upstream & downstream products

Suppliers100 total

北京华美互利生物化工010-56205725 · [email protected]
湖南韵邦生物科技股份有限公司85561037 15386497078 · [email protected]
湖北威德利化学试剂有限公司181-6332-1995 18062128043 · [email protected]
济南百隆化学有限公司[email protected] · [email protected]
武汉英诺医药科技有限公司+86-027-59232304 15387063101 · [email protected]

Related reactions

6 records
New reaction record

Compound notes

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