ST 271
Basic information
- CAS
106392-48-7- Standard SMILES
CC(C)c1cc(/C=C(\C#N)C(N)=O)cc(C(C)C)c1O- InChIKey
HMLQHJRJKQDTKW-UHFFFAOYSA-N- Molecular formula
- C16H20N2O2
- Average molar mass
- 272.34 g/mol
- Monoisotopic mass
- 272.15247789
Names & identifiers
- Preferred name
- ST 271
- IUPAC
- (E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enamide
- English name
- 2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
- Molecular formula
- C16H20N2O2
- Molecular weight
- 272.34
Names & synonyms
106392-48-7ST271ST 271ST-271RefChem:185233(E)-2-cyano-3-[4-hydroxy-3,5-di(propan-2-yl)phenyl]prop-2-enamide2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(E)-2-CYANO-3-(4-HYDROXY-3,5-DIISOPROPYLPHENYL)ACRYLAMIDECHEMBL504173BDBM50292512AKOS037515601BS-14310
Show more names
ST271, >98%ST271, 10 mM in DMSOST271,Phospholipase,inhibit,ST-271,Inhibitor2-Propenamide, 2-cyano-3-(4-hydroxy-3,5-bis(1-methylethyl)phenyl)-
HY-103097N17086s6522BCP207282-cyano-3-(4-hydroorb1223440orb1302798SCHEMBL29354387
Database identifiers
- CAS
106392-48-7- PubChem CID
- 6439072
- ChEMBL
CHEMBL504173
Properties
Computed structural properties
- XLogP
- 3
- Topological polar surface area
- 87.1 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 4
- Heavy atoms
- 20
- Formal charge
- 0
- Complexity
- 413
Physicochemical properties
- Boiling point
- 468.4 · 468.4±45.0 °C(Predicted)
- Density
- 1.137 · 1.137±0.06 g/cm3(Predicted)
- storage temp.
- 2 · 2-8°C
- solubility
- 110 mg/mL · DMSO : ≥ 110 mg/mL (403.91 mM)
- pka
- 10.05 · 10.05±0.40(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 302 · H302-H315-H319-H335
- Precautionary statements
- 261 · P261-P305+P351+P338
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- Hazard statements
- H302-H315-H319-H335
- Precautionary statements
- P261-P305+P351+P338
Chemistry & industry
Applications
UsesST271 is a potent inhibitor of protein tyrosine kinase (PTK), inhibits phospholipase D activation stimulated by fMet-Leu-Phe and PAF, with IC50s of 6.7 and 9 μM, respectively.
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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