Basic information
- CAS
57568-80-6- Standard SMILES
C1CCC(N=C(NC23CC4CC(CC(C4)C2)C3)N2CCOCC2)CC1.Cl- InChIKey
FZALCKUJYZCDOX-UHFFFAOYSA-N- Molecular formula
- C21H36ClN3O
- Average molar mass
- 382 g/mol
- Monoisotopic mass
- 381.2546905
Overview
an antagonist of vascular ATP-sensitive potassium channel openers; structure given in first source
Names & identifiers
- Preferred name
- 4-Morpholinecarboximidamide, N-cyclohexyl-N'-tricyclo(3.3.1.13,7)dec-1-yl-, hydrochloride (1:1)
- IUPAC
- N-(1-adamantyl)-N'-cyclohexylmorpholine-4-carboximidamide;hydrochloride
- English name
- PNU 37883 hydrochloride
- Molecular formula
- C21H36ClN3O
- Molecular weight
- 381.98
Names & synonyms
57568-80-6U-37883AU 37883AU 37883U-37883DTXSID80206200RefChem:912710DTXCID401286914-Morpholinecarboximidamide, N-cyclohexyl-N'-tricyclo(3.3.1.13,7)dec-1-yl-, hydrochloride (1:1)PNU 37883 hydrochloridePNU-37883APNU 37883 (hydrochloride)
Show more names
PNU 37883 HClPNU 37883 hydrochlorU-37883A, ATP-sensitive K+ channel blockerN-CYCLOHEXYL-N'-TRICYCLO[3.3.1.1(3,7)]DEC-1-YL-4-MORPHOLINECARBOXIMIDAMIDE HYDROCHLORIDE
4-Morpholinecarboximidamide, N-cyclohexyl-N'-tricyclo(3.3.1.1(3,7))dec-1-yl-, monohydrochlorideN'-(Adamantan-1-yl)-N-cyclohexylmorpholine-4-carboximidamide hydrochlorideN-[1-Adamantyl]-N-cyclohexyl-4-morpholinecarboxamidine hydrochloride(Z)-N'-(Adamantan-1-yl)-N-cyclohexylmorpholine-4-carboximidamide hydrochloride4-Morpholinecarboximidine-N-1-adamantyl-N'-cyclohexaneFZALCKUJYZCDOX-UHFFFAOYSA-NPNU 37883APNU-3788A
Database identifiers
- CAS
57568-80-6
Properties
Computed structural properties
- Topological polar surface area
- 36.9 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 26
- Formal charge
- 0
- Complexity
- 464
Physicochemical properties
- RTECS
- 9865500 · QD9865500
- storage temp.
- 2 · 2-8°C
- solubility
- 23 mg/mL · DMSO: ~23 mg/mL
- form
- powder
- color
- white
- Safety Statements
- 22 · 22-24/25
- WGK Germany
- 3 · 3
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- safety_code
- 22-24/25
Chemistry & industry
Pharmacology
MeSH Pharmacological ClassificationAgents that promote the excretion of urine through their effects on kidney function.
Applications
UsesPNU 37883 hydrochloride (PNU 37883A) is a selective vascular ATP-sensitive potassium (Kir6, KATP) channels blocker. PNU 37883 hydrochloride has diuretic effects with specific binding in kidney and vascular smooth muscle rather than in brain or pancreatic beta cells[1][2].
Suppliers16 total
上海优宁维生物科技股份有限公司15921930842 15921930842 · [email protected]
杭州摩库生物医药科技有限公司+86-057181025280; +8617767106207 · [email protected]
武汉易泰科技有限公司上海分公司18930552037 · [email protected]
江苏艾康生物医药研发有限公司025-5885952 15955137747 · [email protected]
MedBio脉铂医药021-69568360 18916172912 · [email protected]
BOC Sciences1-631-485-4226; 16314854226 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
上海阿拉丁生化科技股份有限公司6206333 13167063860 · [email protected]
EMMX Biotechnology LLC888-539-0666 · [email protected]
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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