HuagongsheHuagongshe Chemistry Print Report · For research reference only
mycotrienin I
D-Alanine, N-(cyclohexylcarbonyl)-, (5R,6E,8E,10E,13S,14R,15R,16Z)-15-hydroxy-5-methoxy-14,16-dimethyl-3,22,24-trioxo-2-azabicyclo[18.3.1]tetracosa-6,8,10,16,20,23-hexaen-13-yl ester · Mycotrienin · SDZ 115-961 · Ansatrienin A · mycotrienin I · Ansatrienine A · Mycotrienin I, T 23I · Ansatrienin A (Mycotrienin I)
Identifiers & Physical Properties
| CAS No. | 82189-03-5 |
|---|---|
| Molecular formula | C36H48N2O8 |
| Average molar mass | 636.77 g/mol |
| SMILES | CO[C@H]1/C=C/C=C/C=C/C[C@H](OC(=O)[C@@H](C)NC(=O)C2CCCCC2)[C@@H](C)[C@@H](O)/C(C)=C/CCC2=CC(=O)C=C(NC(=O)C1)C2=O |
| PubChem CID | 6440887 |
Chemical & Physical Properties
| Storage conditions | Store at -20°C |
|---|---|
| Solubility | DMF: solubleDMSO: solubleEthanol: solubleMethanol: soluble |
| Physical state | A powder |
| GHS pictogram | GHS07 |
| Signal word | Warning |
| GHS hazard statements | H302+H312+H332-H319 |
| GHS precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P321-P330-P362+P364-P337+P313-P501 |
Safety & Regulations
| Signal word | Warning |
|---|---|
| GHS pictogram | GHS07 |
| GHS hazard statements | H302+H312+H332-H319 |
| GHS precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P321-P330-P362+P364-P337+P313-P501 |
Applications & Uses
Uses
Ansatrienin A, isolated from a Streptomyces sp., is closely related to the cytotrienins and trienomycins. It displays potent activity against tumour cell lines and inhibits osteoclastic bone resorption. Ansatrienin A also significantly potentiates the action of several clinical anti-cancer agents.