Basic information
- CAS
262381-84-0- Standard SMILES
CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@H](C(=O)NCCc1ccc(O)cc1)C(C)CC- InChIKey
RZHVVXDUYUESJI-CPWCDSSXSA-N- Molecular formula
- C20H28N2O6
- Average molar mass
- 392.4 g/mol
- Monoisotopic mass
- 392.19473662
Names & identifiers
- Preferred name
- ethyl (2S,3S)-3-[[(2S)-1-[2-(4-hydroxyphenyl)ethylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
- IUPAC
- ethyl (2S,3S)-3-[[(2S)-1-[2-(4-hydroxyphenyl)ethylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylate
- English name
- N-[[L-trans-3-(Ethoxycarbonyl)oxiran-2-yl]carbonyl]-L-leucyl-3-(p-hydroxyphenyl)ethylamide
- Molecular formula
- C20H28N2O6
- Molecular weight
- 392.45
Names & synonyms
ethyl (2S,3S)-3-[[(2S)-1-[2-(4-hydroxyphenyl)ethylamino]-3-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylateCID644294CHEMBL1242843BDBM36334DTXSID00949102JPM 565(2S,3S)-3-(Ethoxycarbonyl)-N-[(2S)-1-hydroxy-1-{[2-(4-hydroxyphenyl)ethyl]imino}-3-methylpentan-2-yl]oxirane-2-carboximidic acid2-oxiranecarboxylic acid, 3-[[[(1S,2S)-1-[[[2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-2-methylbutyl]amino]carbonyl]-, ethyl ester, (2S,3S)-3-(Ethoxycarbonyl)-N-(1-hydroxy-1-{[2-(4-hydroxyphenyl)ethyl]imino}-3-methylpentan-2-yl)oxirane-2-carboximidic acidOxiranecarboxylic acid, 3-[[[(1S)-1-[[[2-(4-hydroxyphenyl)ethyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-, ethyl ester, (2S,3S)- (9CI)XSC-2JPM-OEt
Show more names
JPM 565-OEtJPM OEt,JPMOEtJPM 565 ethyl esterN-[[L-trans-3-(Ethoxycarbonyl)oxiran-2-yl]carbonyl]-L-leucyl-3-(p-hydroxyphenyl)ethylamide(2S,3S)-3-[[[(1S)-1-[[[2-(4-Hydroxyphenyl)ethyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid ethyl ester
Properties
Computed structural properties
- XLogP
- 2.2
- Topological polar surface area
- 117 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 6
- Rotatable bonds
- 11
- Heavy atoms
- 28
- Formal charge
- 0
- Complexity
- 547
Physicochemical properties
- storage temp.
- 4 °C, · 4°C, protect from light
- solubility
- 125 · DMSO:125.0(Max Conc. mg/mL);318.51(Max Conc. mM)
- form
- Solid
- color
- White to off-white
Chemistry & industry
Applications
UsesJPM-OEt is a broad spectrum cysteine cathepsin inhibitor. JPM-OEt binds covalently in the active site, and irreversibly inhibits the cysteine cathepsin family. Antitumor activity[1][2].
Upstream & downstream products
Upstream raw materials
Suppliers18 total
沈阳中申泽康生物医学技术研究有限公司024-88590548 18698872706 · [email protected]
Aladdin Scientific[email protected]
上海恩诺生物科技有限公司+86 (21) 6435-5022
銳迪國際科技有限公司18024082417 · [email protected]
天津普西唐生物医药科技有限公司010-60605840 · [email protected]
上海陶术生物科技股份有限公司+1-781-999-5354; +1-00000000000 · [email protected]
开封明仁药业有限公司0371-65741762 · [email protected]
上海源叶生物科技有限公司18916372613 · [email protected]
上海陶术生物科技股份有限公司13564774135 · [email protected]
Alabiotech Inc.001-619-354-5251 · [email protected]
Related reactions
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Compound notes
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