R 75317
Basic information
- CAS
115406-25-2- Standard SMILES
CCCCCCCCCCCCCCC/C=C/NC(=O)OC[C@H](COP(=O)(O)OCCN1C=CSC1)Oc1ccon1- InChIKey
NZRRPFIUKBOEPH-DRTHVRHMSA-N- Molecular formula
- C29H50N3O8PS
- Average molar mass
- 631.8 g/mol
- Monoisotopic mass
- 631.30562373
Overview
structure given in first source; platelet activating factor antagonist
Names & identifiers
- Preferred name
- R 75317
- IUPAC
- [(2R)-3-[hydroxy-[2-(2H-1,3-thiazol-3-yl)ethoxy]phosphoryl]oxy-2-(1,2-oxazol-3-yloxy)propyl] N-[(E)-heptadec-1-enyl]carbamate
- English name
- R 75317
- Molecular formula
- C29H50N3O8PS
- Molecular weight
- 631.76
Names & synonyms
115406-25-2R 75317R-75317R-75,317Thiazolium, 3-(4-hydroxy-7-(3-isoxazolyloxy)-10-oxo-3,5,9-trioxa-11-aza-4-phosphaoctacos-1-yl)-, hydroxide, inner salt, P-oxide, (R)-RefChem:178427[(2R)-3-[hydroxy-[2-(2H-1,3-thiazol-3-yl)ethoxy]phosphoryl]oxy-2-(1,2-oxazol-3-yloxy)propyl] N-[(E)-heptadec-1-enyl]carbamate3-(2-(O-(3-(N-Heptadecylcarbamoyloxy)-2-(3-isoxazoyloxy)propyl)phosphonoxy)ethyl)thiazolium(R)-3-(((R)-hydroxy(2-(thiazol-3(2H)-yl)ethoxy)phosphoryl)oxy)-2-(isoxazol-3-yloxy)propyl ((E)-heptadec-1-en-1-yl)carbamateThiazolium, 3-[(7R)-4-hydroxy-7-(3-isoxazolyloxy)-4-oxido-10-oxo-3,5,9-trioxa-11-aza-4-phosphaoctacos-1-yl]-, inner salt
Database identifiers
- CAS
115406-25-2- PubChem CID
- 6444152
Properties
Computed structural properties
- XLogP
- 8.2
- Topological polar surface area
- 158 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 11
- Rotatable bonds
- 27
- Heavy atoms
- 42
- Formal charge
- 0
- Complexity
- 807
Chemistry & industry
Applications
DescriptionR 75317 is a Platelet-activating factor (PAF) antagonist.
UsesR-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis[1].
Related reactions
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Compound notes
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