LY 290324
Basic information
- CAS
146554-87-2- Standard SMILES
Cl.Clc1ccc2ccc(/C=C/c3cccc(Cn4ccc5cccc(CCc6nn[nH]n6)c54)c3)nc2c1- InChIKey
RCQNGLOKKYIZCL-RRAJOLSVSA-N- Molecular formula
- C29H24Cl2N6
- Average molar mass
- 527.4 g/mol
- Monoisotopic mass
- 526.1439502
Overview
a leukotriene D4 receptor antagonist
Names & identifiers
- Preferred name
- LY 290324
- IUPAC
- 7-chloro-2-[(E)-2-[3-[[7-[2-(2H-tetrazol-5-yl)ethyl]indol-1-yl]methyl]phenyl]ethenyl]quinoline;hydrochloride
- English name
- LY 290324
- Molecular formula
- C29H24Cl2N6
- Molecular weight
- 527.45
Names & synonyms
146554-87-2LY 290324ly290324LY-290324Quinoline, 7-chloro-2-(2-(3-((7-(2-(1H-tetrazol-5-yl)ethyl)-1H-indol-1-yl)methyl)phenyl)ethenyl)-, hydrochloride, (E)-RefChem:1545137-chloro-2-[(E)-2-[3-[[7-[2-(2H-tetrazol-5-yl)ethyl]indol-1-yl]methyl]phenyl]ethenyl]quinoline;hydrochlorideQuinoline, 7-chloro-2-((1E)-2-(3-((7-(2-(1H-tetrazol-5-yl)ethyl)-1H-indol-1-yl)methyl)phenyl)ethenyl)-, hydrochlorideorb1700069AKOS040748816HY-120755T27912
Show more names
Quinoline, 7-chloro-2-[(1E)-2-[3-[[7-[2-(1H-tetrazol-5-yl)ethyl]-1H-indol-1-yl]methyl]phenyl]ethenyl]-, hydrochloride (9CI)
Database identifiers
- CAS
146554-87-2- PubChem CID
- 6444265
Properties
Computed structural properties
- Topological polar surface area
- 72.3 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 7
- Heavy atoms
- 37
- Formal charge
- 0
- Complexity
- 735
Chemistry & industry
Applications
DescriptionLY 290324 is an orally active, potent and selective cysteinyl leukotriene ((LTD4) receptor antagonist. In vitro, LY290324 was a potent and persistent antagonist of the contractile responses to LTD4 and LTE4 with pA2 values of 9.1 +/- 0.2 and 8.9 +/- 0.17 respectively. It is also effective in reducing antigen-induced bronchospasm in immunologically sensitised animals.
UsesLY290324 is a potent and orally active leukotriene D4 (LTD4) antagonist. LY290324 reduces LTC4, LTD4 and LTE4 (HY-113465)-induced bronchospasm. LY290324 has the potential for the research of antigen-induced bronchospasm[1].
Related reactions
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Compound notes
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