L-Histidine, hydrazide
Basic information
- CAS
46119-06-6- Standard SMILES
NNC(=O)[C@@H](N)Cc1cnc[nH]1- InChIKey
HIQSHBQGIXVMBC-YFKPBYRVSA-N- Molecular formula
- C6H11N5O
- Average molar mass
- 169.19 g/mol
- Monoisotopic mass
- 169.09635999
Names & identifiers
- Preferred name
- L-Histidine, hydrazide
- IUPAC
- (2S)-2-amino-3-(1H-imidazol-5-yl)propanehydrazide
- English name
- L-Histidine, hydrazide
- Molecular formula
- C6H11N5O
- Molecular weight
- 169.18
Names & synonyms
L-Histidine, hydrazide46119-06-6DTXSID60196731RefChem:350691DTXCID00119222Histidine hydrazideL-histidine hydrazide(2S)-2-amino-3-(1H-imidazol-5-yl)propanehydrazide(S)-2-Amino-3-(1H-imidazol-4-yl)propanehydrazide46119-06-6 (free base)starbld0021870CHEMBL235557
Show more names
Carnosine Impurity 12
SCHEMBL1070085SCHEMBL27946609HIQSHBQGIXVMBC-YFKPBYRVSA-N
Database identifiers
- CAS
46119-06-6- PubChem CID
- 6452043
- DTXSID
DTXSID60196731- ChEMBL
CHEMBL235557- Nikkaji
- J2.460.322I
Properties
Computed structural properties
- XLogP
- -1.9
- Topological polar surface area
- 110 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 3
- Heavy atoms
- 12
- Formal charge
- 0
- Complexity
- 162
Chemistry & industry
Applications
DescriptionL-Histidyl hydrazide, also known as Histidine hydrazide, is a scavenger of 4-hydroxy-2-nonenal. Histidyl hydrazide is effective in reducing brain damage and improving functional outcome in a mouse model of focal ischemic stroke. also protected cultured rat primary neurons against death induced by HNE, chemical hypoxia, glucose deprivation, and combined oxygen and glucose deprivation. Histidine hydrazide prevented neuronal apoptosis as indicated by decreased production of cleaved caspase-3 protein.
Related reactions
0 records
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Compound notes
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