Basic information
- CAS
7081-53-0- Standard SMILES
CCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O.Cl.O- InChIKey
ZOMBFZRWMLIDPX-UHFFFAOYSA-N- Molecular formula
- C24H33ClN2O3
- Average molar mass
- 433 g/mol
- Monoisotopic mass
- 432.2179706
Overview
Doxapram Hydrochloride is a peripheral and central respiratory stimulant with a brief duration of action. Doxapram hydrochloride stimulates respiration by an action on chemoreceptors in the carotid arteries and, at increased dosage, stimulates central respiratory centers in the medulla as well as other parts of the brain and spinal cord. This results in an increased tidal volume and a slightly increased respiratory rate. Doxapram hydrochloride may also improve cardiac output probably due to an increased release of catecholamines. This respiratory stimulant is used in postanesthesia respiratory depression.
Names & identifiers
- Preferred name
- Doxapram Hydrochloride
- IUPAC
- 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one;hydrate;hydrochloride
- English name
- Doxapram hydrochloride monohydrate
- Molecular formula
- C24H30N2O2.ClH.H2O
- Molecular weight
- 432.99
Names & synonyms
Doxapram hydrochloride monohydrateDoxapram HCLStimulexinP5RU6UOQ5YAHR-619NSC-170958NSC-760347DTXCID9027815CHEBI:31520NSC170958RefChem:565601-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-2-pyrrolidinone Monohydrochloride, Monohydrate
Show more names
1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinonehydrochloridehydrDoxapraM HCL APIDoxapram HydrochorideDoxapram hydrochloride CRSDoxapraM Hydrochloride, USPdoxapramhydrochloridehydrateDopram hydrochloride hydrate
Doxapram HydrochlorideDTXSID90478377081-53-0Doxapram hydrochloride hydrate15083-72-4DopramDoxapraM interMediateMFCD09954698
Database identifiers
- CAS
7081-53-0- PubChem CID
- 64648
- DTXSID
Properties
Computed structural properties
- Topological polar surface area
- 33.8 Ų
- Hydrogen bond donors
- 2
- Hydrogen bond acceptors
- 4
- Rotatable bonds
- 6
- Heavy atoms
- 30
- Formal charge
- 0
- Complexity
- 487
Experimental & physicochemical properties
Human Drugs
FDA approved drugs -> Active ingredient
FDA approved drugs -> Active ingredient
Animal DrugsFDA approved animal drugs -> Active ingredient
Physicochemical properties
- Melting point
- 217 · 217-219°
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Soluble in water, in alcohol and in methylene chloride.
- form
- Solid
- color
- White to off-white
- Major Application
- pharmaceutical (small molecule)
- InChI
- InChI=1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2
- InChIKey
- ZOMBFZRWMLIDPX-UHFFFAOYSA-N
- SMILES
- C1(=O)N(CC)CC(CCN2CCOCC2)C1(C1C=CC=CC=1)C1C=CC=CC=1.Cl.O
- FDA UNII
- 5 RU6UOQ5Y · P5RU6UOQ5Y
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
Warning
H302 (96.4%): Harmful if swallowed [Warning Acute toxicity, oral]
P264, P270, P301+P317, P330, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 55 reports by companies from 2 notifications to the ECHA C&L Inventory.
Hazard information
Regulatory InformationDoxapram hydrochloride: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.
Hazard Classes and CategoriesAcute Tox. 4 (96.4%)
Toxicology
Drug Induced Liver Injury
Drug Induced Liver Injury Rank (DILIrank 2.0)
Doxapram hydrochloride
vNo-DILI-concern
0
No match
DOI:10.1016/j.drudis.2016.02.015
Safety data
- wgk
- WGK 3
- ridadr
- UN 2811 6.1 / PGIII
- hs_code
- 2934990002
- Toxicity
- LD50 orally in rats: 261 mg/kg (Goldenthal)
- Signal word
- Danger
- Symbol(GHS)
- GHS06
- Storage Class
- 6.1C - Combustible acute toxic Cat.3toxic compounds or compounds which causing chronic effects
Chemistry & industry
Pharmacology
FDA Pharmacological Classification
DOXAPRAM HYDROCHLORIDE
Increased Medullary Respiratory Drive [PE]; Respiratory Stimulant [EPC]
MeSH Pharmacological Classification
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.
Drugs used for their effects on the respiratory system.
Applications
DescriptionDoxapram is a central respiratory stimulant. It increases respiration and phrenic nerve activity in anesthetized cats at a dose of 1.0 mg/kg. Doxapram acts through carotid chemoreceptors, lacking activity in anesthetized cats following carotid denervation. Formulations containing doxapram have been used to increase respiration in patients with chronic pulmonary disease, respiratory depression induced by drug overdose, and to stimulate deep breathing post-anesthesia.
Usesantibacterial
General DescriptionDoxapram, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride hydrate (Dopram), has an obscuremolecular mechanism of action. Overall, it stimulatesrespiration by action on peripheral carotid chemoreceptors.It has use as a respiratory stimulant postanesthetically, afterCNS depressant drug overdose, in chronic obstructive pulmonarydiseases, and in the apneas. Dopram is administeredexclusively by intravenous injection. Because of the benzylalcohol content of the injectable formulation, Dopram mustnever be given to neonates.
Upstream & downstream products
Upstream raw materials
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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