Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1)
Basic information
- CAS
550-70-9- Standard SMILES
Cc1ccc(C(=CCN2CCCC2)c2ccccn2)cc1.Cl- InChIKey
WYUYEJNGHIOFOC-UHFFFAOYSA-N- Molecular formula
- C19H23ClN2
- Average molar mass
- 314.9 g/mol
- Monoisotopic mass
- 314.1549764
Names & identifiers
- Preferred name
- Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1)
- IUPAC
- 2-[1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochloride
- English name
- trans-Triprolidine hydrochloride
- Molecular formula
- C19H23ClN2
- Molecular weight
- 314.85
Names & synonyms
Pyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-, hydrochloride (1:1)Pyridine, 2-((1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl)-, hydrochloride (1:1)RefChem:8705902-[1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochlorideTriprolidine (Hydrochloride)triprolidine hydrochloride (anh.)Actidilon; Entra; Pro-Actidil; Pro-EntraTriprolidine (hydrochloride monohydrate)SCHEMBL42146(E)-2-(3-(Pyrrolidin-1-yl)-1-(p-tolyl)prop-1-en-1-yl)pyridine hydrochloride2-[(E)-1-(4-methylphenyl)-3-pyrrolidin-1-ylprop-1-enyl]pyridine;hydrochloridePyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride
Show more names
TRIPROLIDINE HCLVenenEntraActidil295 C 51ActidilatPro-entraActidilonPro-actidilEinecs 208-985-0
DB-052682DB-053860NS00093576
Database identifiers
- CAS
550-70-9- PubChem CID
- 64690
Properties
Computed structural properties
- Topological polar surface area
- 16.1 Ų
- Hydrogen bond donors
- 1
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 4
- Heavy atoms
- 22
- Formal charge
- 0
- Complexity
- 335
Physicochemical properties
- Melting point
- 116 · 116-118 °C
- storage temp.
- 2 · 2-8°C
- solubility
- Chloroform (Slightly), Dichloromethane (Slightly), Water (Slightly)
- form
- Powder
- Water Solubility
- 100 mM · Soluble to 100 mM in water
- Stability
- Hygroscopic
- CAS DataBase Reference
- 550 · 550-70-9(CAS DataBase Reference)
- FDA UNII
- 7 A104R3J · NG7A104R3J
- EPA Substance Registry System
- 2 · Pyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl]-, monohydrochloride (550-70-9)
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 319 · H319-H302-H315-H335
- Precautionary statements
- 264 · P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
- Hazard Codes
- Xn
- Risk Statements
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
Safety data
- wgk
- 3
- tsca
- TSCA listed
- rtecs
- UT7658000
- ridadr
- 3249
- Toxicity
- LD50 oral in rat: 840mg/kg
- risk_code
- 22-36/37/38
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xn
- safety_code
- 26-36
- hazard_class
- 6.1(b)
- packing_group
- III
- Hazard statements
- H319-H302-H315-H335
- Precautionary statements
- P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P
Chemistry & industry
Uses & manufacturing
General Manufacturing InformationPyridine, 2-[(1E)-1-(4-methylphenyl)-3-(1-pyrrolidinyl)-1-propen-1-yl]-, hydrochloride (1:1): INACTIVE
Applications
Usestrans-Triprolidine Hydrochloride is a histamine H1 receptor antagonist, which can be used for the prevention of treatment of chronic muscle pain.
UsesTriprolidine is an antihistaminic agent with anticholinergic properties. Triprolidine is used to treat and prevent symptoms associated with allergies. Triprolidine is also used in combination with cold medicine to provide relief for flu-like symptoms.
UsesAntihistaminic;H1 antagonist
Upstream & downstream products
Upstream raw materials
Additional notes
DefinitionChEBI: A hydrochloride resulting from the formal reaction of equimolar amounts of triprolidine and hydrogen chloride. Its monohydrate is used for the symptomatic relief of uticaria, rhinitis, and various pruritic skin disorders.
Related reactions
0 records
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Compound notes
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