Trimazosin Hydrochloride
Basic information
- CAS
53746-46-6- Standard SMILES
COc1cc2c(N)nc(N3CCN(C(=O)OCC(C)(C)O)CC3)nc2c(OC)c1OC.Cl.O- InChIKey
WXMXALSEIGHTOR-UHFFFAOYSA-N- Molecular formula
- C20H32ClN5O7
- Average molar mass
- 489.9 g/mol
- Monoisotopic mass
- 489.1990261
Overview
See also: Trimazosin (has active moiety).
Names & identifiers
- Preferred name
- Trimazosin Hydrochloride
- IUPAC
- (2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate;hydrate;hydrochloride
- English name
- Trimazosin hydrochloride
- Molecular formula
- C20H29N5O6.ClH.H2O
- Molecular weight
- 489.954
Names & synonyms
Trimazosin hydrochloride53746-46-6Trimazosin HClTrimazosin hydrochloride monohydrate827T79ILE7CP-19,106-1CP-19106-1DTXSID40202021RefChem:191719DTXCID40124512Trimazosin hydrochloride [USAN]CP-19106-1 hydrochloride monohydrate
Show more names
Trimazosin monohydrochloride monohydrate4-(4-AMino-6,7,8-triMethoxy-2-quinazolinyl)-1-piperazinecarboxylic Acid 2-Hydroxy-2-Methylpropyl Ester Hydrochloride
(2-hydroxy-2-methylpropyl) 4-(4-amino-6,7,8-trimethoxyquinazolin-2-yl)piperazine-1-carboxylate;hydrate;hydrochloride1-Piperazinecarboxylic acid, 4-(4-amino-6,7,8-trimethoxy-2-quinazolinyl)-, 2-hydroxy-2-methylpropyl ester, monohydrochloride, monohydrate2-Hydroxy-2-methylpropyl 4-(4-amino-6,7,8-trimethoxy-2-quinazolinyl)-1-piperazinecarboxylate monohydrochloride monohydrateTrimazosin hydrochloride (USAN)CardovarSupresUNII-827T79ILE7Trimazosin hydrochlorid-1-wasser
Database identifiers
- CAS
53746-46-6- PubChem CID
- 64749
- DTXSID
DTXSID40202021- ChEMBL
CHEMBL3989848
Properties
Computed structural properties
- Topological polar surface area
- 134 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 11
- Rotatable bonds
- 7
- Heavy atoms
- 33
- Formal charge
- 0
- Complexity
- 603
Physicochemical properties
- Melting point
- 166 · 166-169° (dec)
- storage temp.
- Refrigerator
- solubility
- DMSO (Slightly), Methanol (Slightly), Water (Slightly)
- form
- Solid
- color
- Off-White to Light Beige
- FDA UNII
- 827 T79ILE7 · 827T79ILE7
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Drugs used to cause dilation of the blood vessels.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
Applications
DescriptionTrimazosin hydrochloride is a selective αl-adrenergic antagonist related to prazosin, bunazosin, and terazosin. It is reported to be longer acting than prazosin, without first dose hypotensive effects.
UsesTrimazosin is useful in therapy as potent antihypertensive agents.
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