Pyridine, hydrofluoride (1:1) (HCID 64774)

Overview

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Names & identifiers

Preferred name: Pyridine, hydrofluoride (1:1)
IUPAC: pyridine;hydrofluoride
English name: Pyridine hydrofluoride
Molecular formula: C5H6FN
Molecular weight: 99.11

Names & synonyms

Pyridine hydrofluoride32001-55-1Pyridinium fluoridePyridine, hydrofluoride (1:1)EINECS 250-889-6DTXSID3067653Hydrogen fluoride, pyridine reagent, anhydrousRefChem:177595DTXCID7038444250-889-6Hydrogen Fluoride-Pyridine62778-11-4

Show more names

HFPYRIDINIUM POLY(HYDROGEN FLUORIDE)Olah'sreagentHydrogen Fluoride Pyridine(55%/70%HF)OlahsHydrogen fLuoride pyridineHF 55% IN PYRIDINE

pyridine;hydrofluoridePyridine, hydrofluorideHydrogen fluoride pyridineHF-PyridineHydrogen fluoride-pyridine (70% HF)Olah's ReagentMFCD00012436Hydrogen Fluoride-Pyridine;62778-11-4

Database identifiers

CAS: 32001-55-1、62778-11-4
PubChem CID: 64774
DTXSID: DTXSID3067653
UNII: WS725Z8FJ7
EC Number: 250-889-6、613-082-3

Properties

Computed structural properties

Topological polar surface area: 12.9 Å²
Hydrogen bond donors: 1
Hydrogen bond acceptors: 2
Rotatable bonds: 0
Heavy atoms: 7
Formal charge: 0
Complexity: 30.9

Physicochemical properties

Boiling point: 50 °C · 50°C 1mm
Density: 1.1 g/mL · 1.1 g/mL at 20 °C(lit.)
Flash point: 50 °C/1mm · 50°C/1mm
storage temp.: -20 °C · -20°C Freezer, Under inert atmosphere
solubility: 2 Cl2, · sol CH2Cl2, MeCN, Et2O, THF, toluene, sulfolane.
form: Liquid
color: Clear pale yellow to light brown
Sensitive: Moisture Sensitive
BRN: 4750151 · 4750151
InChI: InChI=1S/C5H5N.FH/c1-2-4-6-5-3-1;/h1-5H;1H
InChIKey: GRJJQCWNZGRKAU-UHFFFAOYSA-N
SMILES: C1=CC=NC=C1.F
CAS DataBase Reference: 32001 · 32001-55-1(CAS DataBase Reference)
EPA Substance Registry System: Pyridine hydrofluoride (32001-55-1)
Symbol(GHS): 7 · GHS07,GHS02
Signal word: Warning
Hazard statements: 315 · H315-H319-H226
Precautionary statements: 501 · P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235
Hazard Codes: T+,C
Risk Statements: 26 · 26/27/28-35-34
Safety Statements: 26 · 26-28-36/37/39-45-27
RIDADR: 1790 · UN 1790 8/PG 1
WGK Germany: 2 · 2
F: 3 · 3-10
TSCA: TSCA listed
HazardClass: 8 · 8
PackingGroup: II
HS Code: 29333999 · 29333999

Safety & regulation

GHS classification

GHS Classification · 6 items

Danger

H300 (100%): Fatal if swallowed [Danger Acute toxicity, oral]

P260, P262, P264, P270, P271, P280, P284, P301+P316, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P320, P321, P330, P361+P364, P363, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 43 reports by companies from 2 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

Danger

H300 (93.3%): Fatal if swallowed [Danger Acute toxicity, oral]

Hazard information

Regulatory Information · 2 items

Pyridine, hydrofluoride: Does not have an individual approval but may be used under an appropriate group standard

Hydrofluoric acid, homopolymer, compd. with pyridine: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

Hazard Classes and Categories · 2 items

Acute Tox. 1 (93.3%)

Acute Tox. 2 (100%)

Safety data

F: 3-10
wgk: 2
tsca: TSCA listed
ridadr: UN 1790 8/PG 1
hs_code: 29333999
risk_code: 26/27/28-35-34
Signal word: Warning
Symbol(GHS): GHS07,GHS02
hazard_code: T+,C
safety_code: 26-28-36/37/39-45-27
hazard_class: 8
packing_group: II
Hazard statements: H315-H319-H226
Precautionary statements: P501-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P403+P235

Chemistry & industry

Uses & manufacturing

General Manufacturing InformationPyridine, hydrofluoride (1:1): ACTIVE

Applications

DescriptionPyridine hydrofluoride has a convenient, less volatile form of anhydrous HF with enhanced nucleophilicity.

UsesPyridinium Poly(hydrogenfluoride) is used in the synthesis of analogues of antimitotic natural product curacin A. It is also an effective fluorinating agent.