2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(E)-nonadec-10-enyl]peroxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]oxolan-3-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
Basic information
- Standard SMILES
CCCCCCCC/C=C/CCCCCCCCCOOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)C1OCC(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO)C1OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO- InChIKey
RGPBUVUVZKQNHD-MDZDMXLPSA-N- Molecular formula
- C185H368O86
- Average molar mass
- 3,969 g/mol
Names & identifiers
- Preferred name
- 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(E)-nonadec-10-enyl]peroxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]oxolan-3-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
- IUPAC
- 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[4-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-5-[1-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]-2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(E)-nonadec-10-enyl]peroxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]oxolan-3-yl]oxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol
- English name
- Tween 80
- Molecular formula
- C24H44O6
- Molecular weight
- 428.600006103516
Names & synonyms
Database identifiers
- CAS
9005-65-6- PubChem CID
- 6479690
Properties
Computed structural properties
- XLogP
- -5.4
- Topological polar surface area
- 827 Ų
- Hydrogen bond donors
- 3
- Hydrogen bond acceptors
- 86
- Rotatable bonds
- 261
- Heavy atoms
- 271
- Formal charge
- 0
- Complexity
- 4,630
Physicochemical properties
- Melting point
- -25 °C · -25 °C
- Boiling point
- 100 °C · >100°C
- Density
- 1.08 g/mL · 1.08 g/mL at 20 °C
- vapor pressure
- 1 mm · <1 mm Hg ( 20 °C)
- refractive index
- 20 · n20/D 1.473
- FEMA
- 2917 · 2917 | POLYSORBATE 80
- Flash point
- 230 °F · >230 °F
- storage temp.
- -20 °C · -20°C
- solubility
- DMSO (Soluble), Methanol (Slightly)
- form
- viscous liquid
- color
- Amber
- Specific Gravity
- 1.08 · 1.080 (25/4℃)
- PH Range
- 6 · 6
- Odor
- mild alcoholic
- PH
- 5 · 5-7 (50g/l, H2O, 20℃)
- Odor Type
- alcoholic
- Viscosity
- 400 · 400-620mPa.s
- biological source
- synthetic
- Water Solubility
- 5 · 5-10 g/100 mL at 23 ºC
- Merck
- 14 · 14,7582
- Hydrophilic-Lipophilic Balance (HLB)
- 10 · 10
- Major Application
- (ELISA and immunoassays)
- Cosmetics Ingredients Functions
- CLEANSINGSURFACTANT - EMULSIFYINGDENATURANTEMULSION STABILISINGSURFACTANT - CLEANSING
- Cosmetic Ingredient Review (CIR)
- 80 · Tween 80 (9005-65-6)
- InChIKey
- RGPBUVUVZKQNHD-MDZDMXLPSA-N
- SMILES
- CCCCCCCC/C=C/CCCCCCCC(=O)OCCOCC(C1C(CC(O1)OCCO)OCCO)OCCO
- LogP
- 4.392 · 4.392 (est)
- Toxicology and Carcinogenesis
- 80 · Toxicology and Carcinogenesis Studies of Polysorbate 80 (CASRN 9005-65-6) in F344/N Rats and B6C3F1 Mice (Feed Studies)
- Substances Added to Food (formerly EAFUS)
- 80 · POLYSORBATE 80
- FDA 21 CFR
- 173.34 · 173.340; 175.105; 176.180;178.3400
- EWG's Food Scores
- 3 · 3-8
- FDA UNII
- 81 · POLYSORBATE 81 (2MSF640LWM)PEG-6 SORBITAN OLEATE (58O7V09UCI)POLYSORBATE 80 (6OZP39ZG8H)
- EPA Substance Registry System
- 80 · Polysorbate 80 (9005-65-6)
- Cosmetics Info
- -6 Sorbitan · PEG-6 Sorbitan Oleate
- UNSPSC Code
- 41116107 · 41116107
- NACRES
- 28 · NA.28
- Symbol(GHS)
- 7 · GHS07
- Signal word
- Warning
- Hazard statements
- 315 · H315-H319-H335
- Precautionary statements
- 261 · P261-P271-P280
- PPE
- Eyeshields, Gloves
- Hazard Codes
- Xi
- Risk Statements
- 22 · 22-36/37/38-37/38-41
- Safety Statements
- 24 · 24/25-36/37/39-36-26
- WGK Germany
- 1 · 1
- RTECS
- 2934000 · WG2934000
- F
- 3 · 3
- TSCA
- TSCA listed
- HS Code
- 34021300 · 34021300
- Storage Class
- 10 · 10 - Combustible liquids
- Hazardous Substances Data
- 9005 · 9005-65-6(Hazardous Substances Data)
- Toxicity
- 50 in · LD50 in mice, rats (ml/kg): 7.5, 6.3 i.p. (Varma)
Safety & regulation
Safety data
- F
- 3
- PPE
- Eyeshields, Gloves
- wgk
- 1
- tsca
- TSCA listed
- rtecs
- WG2934000
- hs_code
- 34021300
- Toxicity
- LD50 in mice, rats (ml/kg): 7.5, 6.3 i.p. (Varma)
- risk_code
- 22-36/37/38-37/38-41
- Signal word
- Warning
- Symbol(GHS)
- GHS07
- hazard_code
- Xi
- safety_code
- 24/25-36/37/39-36-26
- Storage Class
- 10 - Combustible liquids
- Hazard statements
- H315-H319-H335
- Precautionary statements
- P261-P271-P280
- Hazardous Substances Data
- 9005-65-6(Hazardous Substances Data)
Chemistry & industry
Applications
DescriptionTween 80, commonly known as polysorbate 80, is a synthetic compound that is widely applied in a variety of fields, including foods, medicines, and cosmetics. In food production, it is commonly used as a defoamer for the fermenting process of some wines and as a emulsifier in ice-cream or “puddings” to keep the creamy texture without separating. Tween 80 is also extensively applied in pharmaceutical industry, where it can be found in some vaccines, vitamins and supplements. It is an effective excipient to stabilize aqueous formulations of medications for parenteral administration and to improve the consistency of gel capsules, thus to make pills disperse in the stomach. Besides, it commonly serve as a surfactant and solubilizer in the production of soaps and cosmetics, which is effective to help dissolve ingredients and make products look creamier and more attractive. In laboratory, it is occasionally used for a test to identify the phenotype of a strain or isolate, such as mycobacteria.
UsesTween 80 is a general purpose mid-range HLB, ethoxylated, nonionic surfactant suggested for use in textile chemicals (emulsifier, lubricant), household products and cosmetic formulations (o/w emulsifier, viscosity modifier).
UsesTween 80 is used as an antistat for PVC and as an antifog for PP, PE, PVC, PS.
UsesTween 80 is used as an emulsifier (ice cream, whipped topping) and as a solubilizing and dispersing agent in pickles and special vitamin-mineral preparations.
UsesTween 80 is the trade name of a detergent that can be useful in identifying mycobacteria that possess a lipase that splits the compound into oleic acid and polyoxyethylated sorbitol.Tween 80 is used as an additive for cell culture media. It has numerous effects, e.g. increasing the transformation frequency of Brevibacterium lactofermentum or enhancing the secretion of acid and alkaline phosphatase by Neurospora crassa.
General DescriptionAmber-colored viscous liquid. pH (5% aqueous solution) 5-7. Faint odor and bitter taste.Polysorbate 80 (Tween 80) is a synthetic surfactant composed of fatty acid esters of polyoxyethylene sorbitan. Polysorbate 80 is usually available as a chemically diverse mixture of different fatty acid esters, with the oleic acid comprising>58% of the mix. However, the main component of polysorbate 80 is polyoxyethylene-20-sorbitan monooleate, which is structurally similar to polyethylene glycols. Polysorbate 80 has a molecular weight of 1309.7 Da and a 1.064 g/ml density[1].
Upstream & downstream products
Upstream raw materials
Downstream products
Suppliers50 total
Additional notes
DefinitionChEBI: A polymer composed of PEG-ylated sorbitan, where the total number of poly(ethylene glycol) units is 20 (w + x + y + z = 20) and a single terminal is capped by an oleoyl group.
Related reactions
No reaction records under the current filter.
Linked notes
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