| GHS classification | DangerH225: Highly Flammable liquid and vapor [Danger Flammable liquids]P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)H225 (74%): Highly Flammable liquid and vapor [Danger Flammable liquids]P203, P210, P233, P240, P241, P242, P243, P260, P261, P264, P264+P265, P270, P271, P272, P273, P280, P284, P301+P316, P301+P317, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P316, P317, P318, P319, P320, P321, P330, P331, P332+P317, P333+P317, P337+P317, P362+P364, P370+P378, P391, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement) |
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| Regulatory information | Chemical: 4,7-Methano-1H-indene, 3a,4,7,7a-tetrahydro-4,7-Methano-1H-indene, 3a,4,7,7a-tetrahydro- is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 4,7-Methano-1H-indene, 3a,4,7,7a-tetrahydro- are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)2002/2076Status: Active Update: 17-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/154124,7-Methano-1H-indene, 3a,4,7,7a-tetrahydro-: HSNO Approval: HSR001123 Approved with controlsThe New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.) |
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| DOT label | Flammable Liquid |
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| Fire hazards | FLAMMABLE. Flashback along vapor trail may occur. Vapor may explode if ignited in an enclosed area. (USCG, 1999)· HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames.Flammable. Above 32 °C explosive vapour/air mixtures may be formed. |
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| Fire potential | Flammablefire hazardDangerous fire hazard when exposed to heat or flame... |
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| Health hazards | LIQUID OR SOLID: Irritating to skin and eyes. (USCG, 1999)· May cause toxic effects if inhaled or absorbed through skin. |
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| Hazards summary | Exposed workers experienced headaches. The proposed TLVs arre expected to protect against CNS effects (tremors, loss of coordination, and unsteady gait) seen at 33 ppm in mice exposed for 9 days in one unpublished study. [ACGIH] A skin, eye, and respiratory tract irritant[ICSC] In animal experiments, calves are intoxicated at a dose of 250 mg/kg. [HSDB] See Cyclopentadiene. |
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| DOT ID and guide | 2048 130P |
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| Reactive group | Conjugated Dienes |
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| EC classification | Symbol: F, Xn, NR: 11-20/22-36/37/38-51/53S: (2)-36/37-61 |
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| UN classification | UN Hazard Class: 3UN Pack Group: III |
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| Special Reports | EPA/Office of Pollution Prevention and ToxicsHigh Production Volume (HPV) Challenge Program's Robust Summaries and Test Plans. Resin Oils and Cyclodiene Dimer Concentrates.[Available from, as of February 22, 2016:: http://cfpub.epa.gov/hpv-s/] |
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| TSCA requirements | Section 8(a) of TSCA requires manufacturers of this chemical substance to report preliminary assessment information concerned with production, exposure, and use to EPA as cited in the preamble in 51 FR 41329. Effective date: 8/8/95Reporting date: 10/3/95.Pursuant to section 8(d) of TSCA, EPA promulgated a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers, importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpublished health and safety studies. Dicyclopentadiene is included on this list. Effective date: 8/4/95Sunset date: 6/30/98.Manufacturers and processors of dicyclopentadiene are required to conduct in vitro percutaneous absorption rate studies under TSCA section 4. |
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| Fire fighting | Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)polymerization hazard]:Use water in large amounts, foam, carbon dioxide, powder. In case of fire: keep drums, etc., cool by spraying with water. |
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| First aid measures | Fresh air, rest.Remove contaminated clothes. Rinse and then wash skin with water and soap.First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.Rinse mouth. Refer for medical attention . |
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| Accidental release measures | · CALL 911. Then call emergency response telephone number on shipping paper. If shipping paper not available or no answer, refer to appropriate telephone number listed on the inside back cover.· ELIMINATE all ignition sources (no smoking, flares, sparks or flames) from immediate area. |
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| First aid | EYES: First check the victim for contact lenses and remove if present. Flush victim's eyes with water or normal saline solution for 20 to 30 minutes while simultaneously calling a hospital or poison control center. Do not put any ointments, oils, or medication in the victim's eyes without specific instructions from a physician. IMMEDIATELY transport the victim after flushing eyes to a hospital even if no symptoms (such as redness or irritation) develop.General First Aid:(General first aid procedures) |
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| Safe storage | Store only if stabilized. Store in an area without drain or sewer access. Fireproof. Cool. Keep in the dark. Separated from strong oxidants. |
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| Firefighting Hazards | Poisonous gases are produced in fire. |
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| Exposure control and personal protection | · Wear positive pressure self-contained breathing apparatus (SCBA).0.5 [ppm] |
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| Fire fighting procedures | Suitable extinguishing media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.Advice for firefighters: Wear self-contained breathing apparatus for firefighting if necessary.Use water spray to cool unopened containers.Evacuation: If fire becomes uncontrollable or container is exposed to direct flame - consider evacuation of one-third (1/3) mile radius.For more Fire Fighting Procedures (Complete) data for DICYCLOPENTADIENE (8 total), please visit the HSDB record page. |
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| Storage conditions | Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.Store in a flammable liquid storage area or approved cabinet away from ignition sources and corrosive and reactive materials. May form peroxides in storage. ... Before entering a confined space where this chemical may be present, check to make sure that an explosive concentration does not exist. Store in tightly closed containers in a cool, well-ventilated area away from oxidizing materials, strong acids, and strong bases. Sources of ignition, such as smoking and open flames, are prohibited where this chemical is used, handled, or stored in a manner that could create a potential fire or explosion hazard. Metal containers involving the transfer of 5 gallons or more of this chemical should be grounded and bonded. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical./Dicyclopentadiene/ must be inhibited and maintained under an inert atmosphere to prevent polymerization.Store only if stabilized. Store in an area without drain or sewer access. Fireproof. Cool. Keep in the dark. Separated from strong oxidants ... |
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| Cleanup methods | ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Wear respiratory protection. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Remove all sources of ignition. Evacuate personnel to safe areas. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areasEnvironmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoidedMethods and materials for containment and cleaning up: Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.Powders and dusts: Evacuate persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Collect powdered material in the most convenient and safe manner and deposit in sealed containers. Ventilate area after cleanup is complete. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters. ... Liquid: Evacuate and restrict persons not wearing protective equipment from area of spill or leak until cleanup is complete. Remove all ignition sources. Establish forced ventilation to keep levels below explosive limit. Absorb liquids in vermiculite, dry sand, earth, peat, carbon, or a similar material and deposit in sealed containers. Keep this chemical out of a confined space, such as a sewer, because of the possibility of an explosion, unless the sewer is designed to prevent the buildup of explosive concentrations. It may be necessary to contain and dispose of this chemical as a hazardous waste. If material or contaminated runoff enters waterways, notify downstream users of potentially contaminated waters.Remove all ignition sources. Personal protection: A/P2 filter respirator for organic vapor and harmful dust. Do NOT let this chemical enter the environment. Sweep spilled substance into sealable containers, then remove to safe place.Collect with a brush onto a paper sheet. Place in an iron pan in hood. Burn the paper. |
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| Nonfire spill response | Excerpt from ERG Guide 130 [Flammable Liquids (Water-Immiscible / Noxious)polymerization hazard]: |
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| Disposal methods | SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air qualitypotential migration in air, soil or watereffects on animal, aquatic and plant lifeand conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this materialContaminated packaging: Dispose of as unused product.SRP: Wastewater from contaminant suppression, cleaning of protective clothing/equipment, or contaminated sites should be contained and evaluated for subject chemical or decomposition product concentrations. Concentrations shall be lower than applicable environmental discharge or disposal criteria. Alternatively, pretreatment and/or discharge to a permitted wastewater treatment facility is acceptable only after review by the governing authority and assurance that "pass through" violations will not occur. Due consideration shall be given to remediation worker exposure (inhalation, dermal and ingestion) as well as fate during treatment, transfer and disposal. If it is not practicable to manage the chemical in this fashion, it must be evaluated in accordance with EPA 40 CFR Part 261, specifically Subpart B, in order to determine the appropriate local, state and federal requirements for disposal.Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.For more Disposal Methods (Complete) data for DICYCLOPENTADIENE (6 total), please visit the HSDB record page. |
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| Interactions | A retrospective epidemiological study in The Netherlands showed a statistical association between chlorination by-products in drinking water and cancer of the esophagus and stomach for males. A pilot-plant study with alternative disinfectants was carried out with stored water of the Rivers Rhine and Meuse. It was demonstrated that the increase of direct acting mutagens after treatment with chlorine dioxide is similar to the effect of chlorination. Ozonation of Rhine water reduced the mutagenic activity for Salmonella typhimurium TA 98 both with and without metabolic activation. UV alone hardly affects the mutagenicity of the stored river water for S. typhimurium TA 98. In all studies, practically no mutagenic activity for S. typh. TA 100 was found. Although remarkable changes in the concentration of individual organic compounds are reported, the identity of the mutagens detected is yet unclear. Compounds of possible interest due to their removal by ozonation are 1,3,3-trimethyloxindole, dicyclopentadiene and several alkylquinolines. Compounds which might be responsible for the increased mutagenicity after chlorination are two brominated acetonitriles and tri(2-chlorethyl) phosphate. Furthermore, the concentration procedure with adsorption on XAD resin and the subsequent elution step may have affected the results. It is proposed to focus further research more on the less volatile by-products of disinfection than on the trihalomethanes.An added stabilizer or inhibitor can influence the toxicological properties of /dicyclopentadiene/, consult an expert. |
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| Target organs | Eyes, skin, respiratory system, central nervous system, kidneys |
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| Ecotoxicity values | LC50Species: Cyprinus carpio (carp)Concentration: 62.2 mg/L for 96 hr /Conditions of bioassay not specified/EC50Species: Tetrahymena pyriformis (ciliate protozoan)Concentration: 5.3 mg/L for 24 hrEffect: inhibition of cell multiplication /Conditions of bioassay not specified in source examined/Species: Daphnia pulex (Water flea)Conditions: freshwaterstaticConcentration: 4200 ug/L for 48 hrEffect: intoxication, immobile /formulated product/Species: Daphnia magna (Water flea)Concentration: 8.6 mg/L/24 hrConditions: not specifiedEffect: immobilization.For more Ecotoxicity Values (Complete) data for DICYCLOPENTADIENE (47 total), please visit the HSDB record page. |
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| Environmental fate | TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 1500(SRC), determined from a structure estimation method(2), indicates that dicyclopentadiene is expected to have moderate mobility in soil(SRC). Volatilization of dicyclopentadiene from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 0.02 atm-cu m/mole(SRC), derived from its vapor pressure, 2.30 mm Hg(3), and water solubility, 20 mg/L(4). Dicyclopentadiene is expected to volatilize from dry soil surfaces(SRC) based upon its vapor pressure. Two field studies in Alberta, Canada reported soil biodegradation rates of 37-57% in 266 days and not appreciable to 60% in 116 days(5). A 0% of theoretical BOD as reported using activated sludge in a 2-week Japanese MITI test(6). Although biodegradation of dicyclopentadiene does occur, it is not an important environmental fate process in soil(SRC).AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 1500(SRC), determined from a structure estimation method(2), indicates that dicyclopentadiene is expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 0.02 atm-cu m/mole(SRC), derived from its vapor pressure, 2.30 mm Hg(4), and water solubility, 20 mg/L(5). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 3.4 hours and 4.6 days, respectively(SRC). According to a classification scheme(6), a measured BCF range of 58.9-384 in carp (Cyprinus carpio)(7) indicates that bioconcentration in aquatic organisms is moderate to high(SRC). A 0% of theoretical BOD using activated sludge in a 2-week Japanese MITI test(7) indicates that biodegradation is not an important environmental fate process in water(SRC). Photolysis of dicyclopentadiene in natural groudwater by sunlight was found to reduce the concentration by 50% in about 32 day(8). Dicyclopentadiene is an olefin and olefins in surface waters exposed to sunlight react with photo-oxidants (such as hydroxyl radicals, peroxy radicals and singlet oxygen) with a half-life on the order of 25 days(9).ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), dicyclopentadiene, which has a vapor pressure of 2.30 mm Hg at 25 °C(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase dicyclopentadiene is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC)the half-life for this reaction in air is estimated to be 3.2 hours(SRC), calculated from its rate constant of 1.2X10-10 cu cm/molecule-sec at 25 °C(SRC) that was derived using a structure estimation method(3). Dicyclopentadiene is also degraded in the atmosphere by reaction with ozone and nitrate radicals(4). The half-life for the reaction with ozone is estimated to be 11 minutes(SRC), calculated from its rate constant of 1.46X10-15 cu cm/molecule-sec at 25 °C(4). The half-life for the reaction with nitrate radicals is estimated to be 39 minutes(SRC), calculated from its rate constant of 1.2X10-12 cu cm/molecule-sec at 25 °C(4). Dicyclopentadiene absorbs strongly at wavelengths >290 nm(5) and, therefore, may be susceptible to direct photolysis by sunlight(5). |
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| Adverse effects | Neurotoxin - Acute solvent syndrome |
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| Exposure routes | The substance can be absorbed into the body by inhalation and by ingestion.inhalation, ingestion, skin and/or eye contact |
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| Toxicity summary | IDENTIFICATION AND USE: Dicyclopentadiene (DCPD) is a colorless crystalline solid (a liquid above 90 degrees F). DCPD is used in the manufacture of cyclopentadiene as a pesticide intermediatein the production of ferrocene compoundsin paints, varnishes, and resin manufacturein production of elastomers, resin systems, and polymers. It is also used as a repellent for animals such as hares, rabbits, and deer, in winter or in summer. Applied in the form of impregnated strip on deciduous and coniferous trees, or by spraying around ornamental plants and shrubs. HUMAN EXPOSURE AND TOXICITY: Signs of exposure after inhalation--cough, sore throat, and headacheskin exposure--redness and paineyes exposure--redness and painIngestion--abdominal pain, and nausea. Human sensory responses to DCPD were studied in three human volunteers. The odor threshold was reported to be as low as 0.003 ppm. In two of the subjects exposed to 1 and 5.5 ppm for 30 minutes, one subject experienced mild eye and throat irritation after 7 minutes at 1 ppm, and the other subject reported olfactory fatigue after 24 minutes. Eye irritation was reported after 10 minutes, but no olfactory fatigue was reported by either test subject at 5.5 ppm. Accidental exposures of workers, in which headaches were experienced during first 2 months but were not experienced during next 3 months, indicate a certain degree of inurement. ANIMAL STUDIES: In rabbits it was slightly irritating to skin and eyes. Three of four rats survived ten 6-hour daily exposures at 250 ppm, and all survived 15 such exposures at 100 ppm. On daily, repeated exposures to DCPD for 10 days, rats succumbed at the 332 ppm level, but not at the 146 and 72 ppm levels. All dying rats succumbed with convulsions and hemorrhage of the lungs with blood in the intestineswith the females, hemorrhage of the thymus. Mice exposed under the same schedule died at both 146 and 72 ppm. After exposures of 7 hours/day for 89 exposure days, kidney damage was seen in rats exposed at 74 and 35 ppm DCPD. Some lung involvement was seen as chronic pneumonia and bronchiectasis, but no dose related effect was seen in other organs examined. Dogs exposed under the same schedule (89 exposure days) at 32, 23, and 9 ppm DCPD showed only minimal changes in the biochemical tests used, and no changes that were dose-related in 28 organs examined. Hyaline droplets in the proximal convoluted tubular epithelial cells of the kidney were seen in male rats exposed to 5 and 50ppm DCPD and tubular proteinosis was seen by week 13 in all male rats exposed to 50ppm DCPD. Mice were exposed to DCPD by inhalation for 7 hours per day, 5 days per week for 10 days at 47, 72, and 146 ppm. All mice exhibited convulsive deaths on the first day of exposure. Death at 72 ppm occurred in five of six mice of each sex during the 10 days of exposure and was not associated with the convulsions or gross lesions observed in rats. No deaths occurred at 47 ppm and no other effects of treatment were observed. In other study four groups, each consisting of 45 male and 45 female B6C3F1 mice, were exposed to DCPD vapor by inhalation 6 hr/day, 5 days/week, for 13 weeks (64 exposures) at targeted concentrations of 0, 1.0, 5.0, or 50 ppm. Ten male and nine female mice in the highest exposure group died during the study, while no more than two mice died in any other group. 20 female pregnant rats were admin DCPD orally at 0, 80, 250, 750 mg/kg/day for days 6 to 15 gestation. On day 19, the dams were sacrificed and examinedeach uterus was examined for implantation sites, placement in uterine horns, number of live and dead fetuses and resorptions. Fetuses were examined for soft tissue changes and skeletal abnormalities. No compound-related gross pathological effects or changes in reproductive performance were seen in the dams. There were no visceral or skeletal malformations or changes in sex ratio in the fetuses. DCPD was not mutagenic in the Salmonella assay at doses of 0, 3, 10, 33, 100, and 333 ug/plate in Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537) with or without metabolic activation. DCPD did not induce structural chromosomal aberration or polyploidy in CHL/IU cellsnegative finding were confirmed in the in vitro micronucleus test. |
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| Signs and Symptoms | Cough. Sore throat. Headache.Redness. Pain.Abdominal pain. Nausea.irritation eyes, skin, nose, throatincoordination, headachesneezing, coughskin blistersIn Animals: kidney, lung damage |
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| Ongoing Test Status | EPA has released the Interactive Chemical Safety for Sustainability (iCSS) Dashboard. The iCSS Dashboard provides an interactive tool to explore rapid, automated (or in vitro high-throughput) chemical screening data generated by the Toxicity Forecaster (ToxCast) project and the federal Toxicity Testing in the 21st century (Tox21) collaboration. /The title compound was tested by ToxCast and/or Tox21 assays/[USEPAICSS Dashboard ApplicationAvailable from, as of December 17, 2015: http://actor.epa.gov/dashboard/] |
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| Effluent Concentrations | Dicyclopentadiene has been found in two of sixty-three industrial effluent samples obtained from a wide range of chemical manufacturers from 1976-1978 in areas across the USA at a concentration of <10 ug/L(1). Dicyclopentadiene was found in one of three publically owned treatment facilities in NJ at a concentration of 9 ppb(2). |
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| ICSC Environmental Data | The substance is toxic to aquatic organisms. |
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| Soil Adsorption/Mobility | Using a structure estimation method based on molecular connectivity indices(1), the Koc of dicyclopentadiene can be estimated to be 1500(SRC). According to a classification scheme(2), this estimated Koc value suggests that dicyclopentadiene is expected to have low mobility in soil. |
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| Signal word | Warning |
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| GHS pictogram | GHS07 |
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| GHS hazard statements | H302-H315-H319-H335 |
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| GHS precautionary statements | P280-P305+P351+P338 |
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