2,2-Dimethoxypropane
Basic information
- CAS
77-76-9- Standard SMILES
COC(C)(C)OC- InChIKey
HEWZVZIVELJPQZ-UHFFFAOYSA-N- Molecular formula
- C5H12O2
- Average molar mass
- 104.15 g/mol
- Monoisotopic mass
- 104.08372962
Overview
dehydrating agent in electron microscopy specimen preparation; structure
Names & identifiers
- Preferred name
- 2,2-Dimethoxypropane
- IUPAC
- 2,2-dimethoxypropane
- English name
- 2,2-Dimethoxypropane
- Molecular formula
- C5H12O2
- Molecular weight
- 104.15
Names & synonyms
2,2-DIMETHOXYPROPANE77-76-9Acetone dimethyl acetalPropane, 2,2-dimethoxy-Acetone dimethyl ketalDTXSID7026441NSC-62085DTXCID00644166P41R0030RefChem:81029201-056-0Acetone, dimethyl acetal
Show more names
DMP)2,2-DiMethoxyAcetone dimethyl acetal, DMPNSC 62085C.I. 777692,2-dimethoxy-propanDimolybdenum trioxide
dimethoxypropan2,2-DimethyoxypropaneGadobutrol Impurity 16dimethoxy propane2,2-dimethoxypropan2,2-dimetoxypropaneacetone dimethylacetalPropane,2-dimethoxy-
Database identifiers
- CAS
77-76-9- PubChem CID
- 6495
- DTXSID
DTXSID7026441- ChEMBL
CHEMBL3184215- UNII
- 66P41R0030
- EC Number
- 201-056-0
- Nikkaji
- J35.930K
Properties
Computed structural properties
- XLogP
- 0.6
- Topological polar surface area
- 18.5 Ų
- Hydrogen bond donors
- 0
- Hydrogen bond acceptors
- 2
- Rotatable bonds
- 2
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 44
Experimental & physicochemical properties
Chemical ClassesOther Classes -> Acetals
SpringerMaterials PropertiesSchoenflies notation
Density0.847 @25 °C
Boiling Point83 °C @760 [mm Hg]
Melting Point-47 °C
Physical DescriptionClear colorless liquid; [MSDSonline]
Physicochemical properties
- Melting point
- -47 °C · -47 °C
- Boiling point
- 83 °C · 83 °C (lit.)
- Density
- 0.847 g/mL · 0.847 g/mL at 25 °C (lit.)
- vapor density
- 3.59 · 3.59 (vs air)
- vapor pressure
- 60 mm · 60 mm Hg ( 15.8 °C)
- refractive index
- 20 · n20/D 1.378(lit.)
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 2.3% (5 of 222) of reports.
Danger
H225 (97.7%): Highly Flammable liquid and vapor [Danger Flammable liquids]
P210, P233, P240, P241, P242, P243, P261, P264, P264+P265, P271, P280, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P370+P378, P403+P233, P403+P235, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 222 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Propane, 2,2-dimethoxy-
REACH registered substance: Acetone-dimethyl acetal (EC: 201-056-0)
2,2-Dimethoxypropane: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryAn eye irritant; [eChemPortal: ERMA] An irritant; [MSDSonline]
Peroxide Forming Chemical
2,2-Dimethoxypropane
D*: Other compounds that may form peroxides
2 samples had 3-10 ppm peroxide; age >1 yrs
Management of time-sensitive chemicals (JCHAS)
Hazard Classes and CategoriesFlam. Liq. 2 (97.7%)
Safety & protection
Protective Action Criteria (PAC)
2.8 [ppm]
Chemistry & industry
Uses & manufacturing
UsesDehydrating agent in electron microscopy specimen preparation. [ChemIDplus]
General Manufacturing InformationPropane, 2,2-dimethoxy-: ACTIVE
Applications
Uses2,2-Dimethoxypropane acts as a dehydrating agent. It also serves as an intermediate in the synthesis of vitamin E, vitamin A and various carotenoids such as astaxanthin. It is used as a reagent for the preparation of 1,2-diols, acetonides, isopropylidene derivatives of sugars, nucleosides, methyl esters of amino acids and enol ethers.
Uses2,2-Dimethoxypropane(DMP) is used in histology and considered to be more efficient than ethanol for the dehydration of animal tissue.
General Description2,2-Dimethoxypropane is an organic compound, which may be used as a protecting agent in the process of the synthesis of structurally related alkaloids like narciclasine and lycoricidine using phenylbromide as the starting material.
Upstream & downstream products
Upstream raw materials
Downstream products
Related reactions
860 records
Compound notes
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