Basic information
- CAS
593-84-0- Standard SMILES
N#CS.N=C(N)N- InChIKey
ZJYYHGLJYGJLLN-UHFFFAOYSA-N- Molecular formula
- CH5N3.CHNS
- Average molar mass
- 118.16 g/mol
- Monoisotopic mass
- 118.03131738
Overview
a powerful chaotropic agent
Names & identifiers
- Preferred name
- Guanidine thiocyanate
- IUPAC
- guanidine;thiocyanic acid
- English name
- Guanidine thiocyanate
- Molecular formula
- CH5N3.CHNS
- Molecular weight
- 118.16
Names & synonyms
Guanidine thiocyanate593-84-0Guanidinium thiocyanateGuanidine, monothiocyanateBUFFER AVLGCA2EU297UGuSCNNSC-2119DTXSID6060478RefChem:144652DTXCID1042601209-812-1
Show more names
GUANIDINIUM ISOTHIOCYANATEGdmSCNabs9138usafek-705GUANIDIN THIOCYGTC,guanidineth
guanidine isothiocyanateguanidine;thiocyanic acidGuanidinium rhodanideMFCD00013027USAF EK-705M01833GTCguanidinethiocyanate
Database identifiers
- CAS
593-84-0- PubChem CID
- 65046
- DTXSID
DTXSID6060478- UNII
- GCA2EU297U
- EC Number
- 209-812-1
Properties
Computed structural properties
- Topological polar surface area
- 101 Ų
- Hydrogen bond donors
- 4
- Hydrogen bond acceptors
- 3
- Rotatable bonds
- 0
- Heavy atoms
- 7
- Formal charge
- 0
- Complexity
- 57.6
Experimental & physicochemical properties
Chemical ClassesOther Uses -> Biochemical Research
Physical Description
Liquid; Dry Powder
White crystalline solid; Hygroscopic; [Sigma-Aldrich MSDS]
Physicochemical properties
- Melting point
- 120 · 120-122 °C(lit.)
- Density
- 1.103 g/mL · 1.103 g/mL at 20 °C
- bulk density
- 630 kg/m3 · 630kg/m3
- vapor pressure
- 0 Pa · 0Pa at 20℃
- refractive index
- 20 · n20/D 1.482
- storage temp.
- 20 · 20-25°C
- solubility
- 2 O: · H2O: 6 M at 20 °C, clear, colorless
- form
- Crystals or Crystalline Powder
- pka
- 12.5 · 12.5[at 20 ℃]
- color
- White or colorless
- Specific Gravity
- 1.152 · 1.152
Safety & regulation
Safety information is for reference only and does not replace the supplier’s Safety Data Sheet (SDS), applicable regulations, or professional assessment.
GHS classification
GHS Classification
This chemical does not meet GHS hazard criteria for 0.2% (1 of 404) of reports.
Danger
H302+H312+H332 (45.3%): Harmful if swallowed, in contact with skin or if inhaled [Warning Acute toxicity, oral; acute toxicity, dermal; acute toxicity, inhalation]
P260, P261, P264, P264+P265, P270, P271, P273, P280, P301+P317, P301+P330+P331, P302+P352, P302+P361+P354, P304+P340, P305+P354+P338, P316, P317, P321, P330, P362+P364, P363, P405, and P501 (click each P-code to see the statement)
Aggregated GHS information provided per 404 reports by companies from 22 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.
Hazard information
Regulatory Information
Chemical: Thiocyanic acid, compound with guanidine (1:1)
Thiocyanic acid, compd. with guanidine (1:1) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Thiocyanic acid, compd. with guanidine (1:1) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)
REACH registered substance: Guanidinium thiocyanate (EC: 209-812-1)
Guanidinium thiocyanate: Does not have an individual approval but may be used under an appropriate group standard
Hazards SummaryIntraperitoneal LD50 (mouse) = 300 mg/kg; [RTECS] Causes burns; Inhalation may cause corrosive injuries to upper respiratory tract and lungs; Harmful by ingestion; [Sigma-Aldrich MSDS] See Guanidine. See Sodium thiocyanate.
Hazard Classes and CategoriesAcute Tox. 4 (98.3%)
Safety & protection
Chemistry & industry
Pharmacology
MeSH Pharmacological Classification
Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed)
Uses & manufacturing
UsesA powerful chaotropic agent. [ChemIDplus] Used for RNA isolation and can solubilize proteins; [Santa Cruz Biotechnology]
U.S. Production2023: <50,000 lb
Consumer UsesLaboratory chemicals
Industry UsesLaboratory chemicals
General Manufacturing Information
Other (requires additional information)
Thiocyanic acid, compd. with guanidine (1:1): ACTIVE
Applications
DescriptionGuanidine thiocyanate is one of the cheapest and easiest to prepare of the guanidine salts. Guanidine Thiocyanate is an ultrapure, molecular biology grade reagent. It is free of detectable nuclease and protease activity and is a strong protein denaturant, as both the guanidinium cation and the thiocyanate anion are chaotropic agents. It is provided in one bottle containing 500 g. It is recommended for isolation of RNA, especially for tissues such as pancreas with high levels of RNase activity. In solution, it is known as guanidinium thiocyanate. Guanidine Thiocyanate is thoroughly tested for contaminating nonspecific endonuclease, exonuclease, and RNase activity.
Related reactions
0 records
No reaction records under the current filter.
Compound notes
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